PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction

Biochemical and Biophysical Research Communications

Volumn 461, Issue 2, 2015, Pages 366-371

  Kato, Masaya ^a   Muromoto, Ryuta ^a   Togi, Sumihito ^a   Iwakami, Masashi ^a   Kitai, Yuichi ^a   Kon, Shigeyuki ^a   Oritani, Kenji ^b   Matsuda, Tadashi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

HDAC3; Hepatoma; IL 6; PML; STAT3; Transcriptional regulation

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 3; INTERLEUKIN 6; NUCLEAR PROTEIN; PML PROTEIN, HUMAN; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; INTERLEUKIN-6; LIVER NEOPLASMS; NUCLEAR PROTEINS; PROTEIN INTERACTION MAPS; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS;

EID: 84937759819     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.04.040     Document Type: Article

References (34)

1. T. Kishimoto, S. Akira, and T. Taga Interleukin-6 and its receptor: a paradigm for cytokines Science 258 1992 593 597
2. T. Matsuda, and T. Hirano J. Oppenheim, M. Feldmann, Interleukin 6 in cytokine reference 2000 Academic Press London 537 563
3. C. Dong Th17 cells in development: an updated view of their molecular identity and genetic programming Nat. Rev. Immunol. 8 2008 337 348
4. A. Kimura, and T. Kishimoto IL-6: regulator of Treg/Th17 balance Eur. J. Immunol. 40 2010 1830 1835
5. G.K. Michalopoulos Liver regeneration J. Cell. Physiol. 213 2007 286 300
6. D.E. Cressman, L.E. Greenbaum, R.A. DeAngelis, and et al Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice Science 274 1996 1379 1383
7. T. Hirano, K. Nakajima, and M. Hibi Signaling mechanisms through gp130: a model of the cytokine system Cytokine Growth Factor Rev. 8 1997 241 252
8. T. Kishimoto, T. Taga, and S. Akira Cytokine signal transduction Cell 76 1994 253 262
9. D.E. Levy, and C.K. Lee What does Stat3 do? J. Clin. Invest. 109 2002 1143 1148
10. T. Bowman, R. Garcia, J. Turkson, and et al STATs in oncogenesis Oncogene 19 2000 2474 2488
11. J. Bromberg, and J.E. Darnell Jr. The role of STATs in transcriptional control and their impact on cellular function Oncogene 19 2000 2468 2473
12. K. Shuai, and B. Liu Regulation of JAK-STAT signalling in the immune system Nat. Rev. Immunol. 3 2003 900 911
13. H. Yasukawa, A. Sasaki, and A. Yoshimura Negative regulation of cytokine signaling pathways Annu. Rev. Immunol. 18 2000 143 164
14. D.L. Krebs, and D.J. Hilton SOCS proteins: negative regulators of cytokine signaling Stem Cells 19 2001 378 387
15. T. Yamamoto, Y. Sekine, K. Kashima, and et al The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation Biochem. Biophys. Res. Commun. 297 2002 811 817
16. T. Tanaka, Y. Yamamoto, R. Muromoto, and et al PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3 Sci. Signal. 4 2011 ra85
17. A. Kawasaki, I. Matsumura, Y. Kataoka, and et al Opposing effects of PML and PML/RAR alpha on STAT3 activity Blood 101 2003 3668 3673
18. R. Bernardi, and P.P. Pandolfi Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies Nat. Rev. Mol. Cell. Biol. 8 2007 1006 1016
19. Y.H. Choi, R. Bernardi, P.P. Pandolfi, and et al The promyelocytic leukemia protein functions as a negative regulator of IFN-gamma signaling Proc. Natl. Acad. Sci. U. S. A. 103 2006 18715 18720
20. S. Togi, S. Kamitani, S. Kawakami, and et al HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A Biochem. Biophys. Res. Commun. 379 2009 616 620
21. T. Matsuda, T. Yamamoto, A. Muraguchi, and et al Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3 J. Biol. Chem. 276 2001 42908 42914
22. W.S. Wu, S. Vallian, E. Seto, and et al The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases Mol. Cell. Biol. 21 2001 2259 2268
23. S.A. Williams, L.F. Chen, H. Kwon, and et al NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation EMBO J. 25 2006 139 149
24. Y. Zhao, S. Lu, L. Wu, and et al Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1) Mol. Cell. Biol. 26 2006 2782 2790
25. C.K. Lau, Z.F. Yang, S.P. Lam, and et al Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma Cancer Biol. Ther. 6 2007 1900 1907
26. L. Lin, R. Amin, G.I. Gallicano, and et al The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling Oncogene 28 2009 961 972
27. W.K. Chu, P.M. Dai, H.L. Li, and et al Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3 J. Biol. Chem. 283 2008 7328 7337
28. C.M. Grozinger, and S.L. Schreiber Deacetylase enzymes: biological functions and the use of small-molecule inhibitors Chem. Biol. 9 2002 3 16
29. Z.L. Yuan, Y.J. Guan, D. Chatterjee, and et al Stat3 dimerization regulated by reversible acetylation of a single lysine residue Science 307 2005 269 273
30. A. Catania, C. Iavarone, S.M. Carlomagno, and et al Selective transcription and cellular proliferation induced by PDGF require histone deacetylase activity Biochem. Biophys. Res. Commun. 343 2006 544 554
31. M. Gupta, J.J. Han, M. Stenson, and et al Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy Leukemia 26 2012 1356 1364
32. J. Minami, R. Suzuki, R. Mazitschek, and et al Histone deacetylase 3 as a novel therapeutic target in multiple myeloma Leukemia 28 2014 680 689
33. R. Tsuruma, N. Ohbayashi, S. Kamitani, and et al Physical and functional interactions between STAT3 and KAP1 Oncogene 27 2008 3054 3059
34. C. Gurrieri, P. Capodieci, R. Bernardi, and et al Loss of the tumor suppressor PML in human cancers of multiple histologic origins J. Natl. Cancer Inst. 96 2004 269 279