메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; STAT1 PROTEIN; STAT3 PROTEIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

EID: 84940188905     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13414     Document Type: Article
Times cited : (47)

References (63)
  • 1
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray, P. J. & Wynn, T. A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11, 723-737 (2011
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 2
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M. & Edwards, J. P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969 (2008
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 3
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai, T. & Akira, S. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity 34, 637-650 (2011
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 4
    • 3142654210 scopus 로고    scopus 로고
    • Inferences questions and possibilities in toll-like receptor signalling
    • Beutler, B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430, 257-263 (2004
    • (2004) Nature , vol.430 , pp. 257-263
    • Beutler, B.1
  • 5
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805-820 (2010
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 6
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on toll-like receptors
    • Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010
    • (2010) Nat. Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 8
    • 55149093640 scopus 로고    scopus 로고
    • Regulation of interferon and toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
    • Hu, X., Chakravarty, S. D. & Ivashkiv, L. B. Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol. Rev. 226, 41-56 (2008
    • (2008) Immunol. Rev , vol.226 , pp. 41-56
    • Hu, X.1    Chakravarty, S.D.2    Ivashkiv, L.B.3
  • 9
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: An overview of signals, mechanisms and functions
    • Schroder, K., Hertzog, P. J., Ravasi, T. & Hume, D. A. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75, 163-189 (2004
    • (2004) J. Leukoc. Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 10
    • 70349736116 scopus 로고    scopus 로고
    • Cross-regulation of signaling pathways by interferon-gamma: Implications for immune responses and autoimmune diseases
    • Hu, X. & Ivashkiv, L. B. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 31, 539-550 (2009
    • (2009) Immunity , vol.31 , pp. 539-550
    • Hu, X.1    Ivashkiv, L.B.2
  • 12
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor stat91 involves dimerization through sh2-phosphotyrosyl peptide interactions
    • Shuai, K., et al. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76, 821-828 (1994
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1
  • 13
    • 0028234529 scopus 로고
    • Jak-stat pathways and transcriptional activation in response to ifns and other extracellular signaling proteins
    • Darnell, J. E., Jr., Kerr, I. M. & Stark, G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 14
    • 0034306290 scopus 로고    scopus 로고
    • Stat proteins and transcriptional responses to extracellular signals
    • Horvath, C. M. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem. Sci. 25, 496-502 (2000
    • (2000) Trends Biochem. Sci , vol.25 , pp. 496-502
    • Horvath, C.M.1
  • 15
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the stat1 gene in mice reveals unexpected physiologic specificity in the jak-stat signaling pathway
    • Meraz, M. A., et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-442 (1996
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 16
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., Hackenmiller, R., Simon, M. C. & Levy, D. E. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84, 443-450 (1996
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 17
    • 0037371835 scopus 로고    scopus 로고
    • Impaired response to interferon-Alpha/beta and lethal viral disease in human stat1 deficiency
    • Dupuis, S., et al. Impaired response to interferon-Alpha/beta and lethal viral disease in human STAT1 deficiency. Nat. Genet. 33, 388-391 (2003
    • (2003) Nat. Genet , vol.33 , pp. 388-391
    • Dupuis, S.1
  • 18
    • 57149144518 scopus 로고    scopus 로고
    • The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases
    • Al-Muhsen, S. & Casanova, J. L. The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases. J. Allergy Clin. Immunol. 122, 1043-1051 (2008
    • (2008) J. Allergy Clin. Immunol , vol.122 , pp. 1043-1051
    • Al-Muhsen, S.1    Casanova, J.L.2
  • 19
    • 0036476551 scopus 로고    scopus 로고
    • Stat1-dependent and-independent pathways in ifn-gamma-dependent signaling
    • Ramana, C. V., Gil, M. P., Schreiber, R. D. & Stark, G. R. Stat1-dependent and-independent pathways in IFN-gamma-dependent signaling. Trends Immunol. 23, 96-101 (2002
    • (2002) Trends Immunol , vol.23 , pp. 96-101
    • Ramana, C.V.1    Gil, M.P.2    Schreiber, R.D.3    Stark, G.R.4
  • 20
    • 0035811006 scopus 로고    scopus 로고
    • Biologic consequences of stat1-independent ifn signaling
    • Gil, M. P., et al. Biologic consequences of Stat1-independent IFN signaling. Proc. Natl. Acad. Sci. USA 98, 6680-6685 (2001
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6680-6685
    • Gil, M.P.1
  • 21
    • 0035810953 scopus 로고    scopus 로고
    • Stat1-independent regulation of gene expression in response to ifn-gamma
    • Ramana, C. V., et al. Stat1-independent regulation of gene expression in response to IFN-gamma. Proc. Natl. Acad. Sci. USA 98, 6674-6679 (2001
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6674-6679
    • Ramana, C.V.1
  • 22
    • 33846202008 scopus 로고    scopus 로고
    • Stat1 as a key modulator of cell death
    • Kim, H. S. & Lee, M. S. STAT1 as a key modulator of cell death. Cell. Signal. 19, 454-465 (2007
    • (2007) Cell. Signal , vol.19 , pp. 454-465
    • Kim, H.S.1    Lee, M.S.2
  • 23
    • 13844296660 scopus 로고    scopus 로고
    • Viruses evade the immune system through type i interferon-mediated stat2-dependent, but stat1-independent, signaling
    • Hahm, B., Trifilo, M. J., Zuniga, E. I. & Oldstone, M. B. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity 22, 247-257 (2005
    • (2005) Immunity , vol.22 , pp. 247-257
    • Hahm, B.1    Trifilo, M.J.2    Zuniga, E.I.3    Oldstone, M.B.4
  • 24
    • 79952237300 scopus 로고    scopus 로고
    • Stat2 mediates innate immunity to dengue virus in the absence of stat1 via the type i interferon receptor
    • Perry, S. T., Buck, M. D., Lada, S. M., Schindler, C. & Shresta, S. STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor. PLoS Pathog. 7, e1001297 (2011
    • (2011) PLoS Pathog , vol.7 , pp. e1001297
    • Perry, S.T.1    Buck, M.D.2    Lada, S.M.3    Schindler, C.4    Shresta, S.5
  • 25
    • 0032127465 scopus 로고    scopus 로고
    • Stat1 combines signals derived from ifn-gamma and lps receptors during macrophage activation
    • Kovarik, P., Stoiber, D., Novy, M. & Decker, T. Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation. EMBO J. 17, 3660-3668 (1998
    • (1998) EMBO J. , vol.17 , pp. 3660-3668
    • Kovarik, P.1    Stoiber, D.2    Novy, M.3    Decker, T.4
  • 26
    • 0036222241 scopus 로고    scopus 로고
    • Tlr4, but not tlr2, mediates ifn-beta-induced stat1alpha/beta-dependent gene expression in macrophages
    • Toshchakov, V., et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat. Immunol. 3, 392-398 (2002
    • (2002) Nat. Immunol , vol.3 , pp. 392-398
    • Toshchakov, V.1
  • 27
    • 34548036686 scopus 로고    scopus 로고
    • Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
    • Kim, H. S., et al. Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes. Immunity 27, 321-333 (2007
    • (2007) Immunity , vol.27 , pp. 321-333
    • Kim, H.S.1
  • 28
    • 37549011741 scopus 로고    scopus 로고
    • Ifn-beta modulates the response to tlr stimulation in human dc: Involvement of ifn regulatory factor-1 (irf-1) in il-27 gene expression
    • Remoli, M. E., et al. IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur. J. Immunol. 37, 3499-3508 (2007
    • (2007) Eur. J. Immunol , vol.37 , pp. 3499-3508
    • Remoli, M.E.1
  • 29
    • 84865772924 scopus 로고    scopus 로고
    • Type i and III interferons enhance il-10r expression on human monocytes and macrophages, resulting in il-10-mediated suppression of tlr-induced il-12
    • Liu, B. S., Janssen, H. L. & Boonstra, A. Type I and III interferons enhance IL-10R expression on human monocytes and macrophages, resulting in IL-10-mediated suppression of TLR-induced IL-12. Eur. J. Immunol. 42, 2431-2440 (2012
    • (2012) Eur. J. Immunol , vol.42 , pp. 2431-2440
    • Liu, B.S.1    Janssen, H.L.2    Boonstra, A.3
  • 30
    • 84863981921 scopus 로고    scopus 로고
    • Macrophages from nonobese diabetic mouse have a selective defect in ifn-gamma but not ifn-Alpha/beta receptor pathway
    • Lee, M. S., Kwon, H. J. & Kim, H. S. Macrophages from Nonobese Diabetic Mouse Have a Selective Defect in IFN-gamma but Not IFN-Alpha/beta Receptor Pathway. J. Clin. Immunol. 32, 753-761 (2012
    • (2012) J. Clin. Immunol , vol.32 , pp. 753-761
    • Lee, M.S.1    Kwon, H.J.2    Kim, H.S.3
  • 31
    • 0031017252 scopus 로고    scopus 로고
    • Interferon-Alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection
    • Cousens, L. P., Orange, J. S., Su, H. C. & Biron, C. A. Interferon-Alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94, 634-639 (1997
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 634-639
    • Cousens, L.P.1    Orange, J.S.2    Su, H.C.3    Biron, C.A.4
  • 32
    • 0037452789 scopus 로고    scopus 로고
    • Stat3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of stat3 in innate immunity
    • Welte, T., et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc. Natl. Acad. Sci. USA 100, 1879-1884 (2003
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1879-1884
    • Welte, T.1
  • 33
    • 11244348125 scopus 로고    scopus 로고
    • Stat3 regulates nf-kappab recruitment to the il-12p40 promoter in dendritic cells
    • Hoentjen, F., Sartor, R. B., Ozaki, M. & Jobin, C. STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. Blood 105, 689-696 (2005
    • (2005) Blood , vol.105 , pp. 689-696
    • Hoentjen, F.1    Sartor, R.B.2    Ozaki, M.3    Jobin, C.4
  • 34
    • 70949094349 scopus 로고    scopus 로고
    • The jak2 inhibitor azd1480 potently blocks stat3 signaling and oncogenesis in solid tumors
    • Hedvat, M., et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 16, 487-497 (2009
    • (2009) Cancer Cell , vol.16 , pp. 487-497
    • Hedvat, M.1
  • 35
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-Type cytokine signalling through the gp130/jak/stat pathway
    • Heinrich, P. C., Behrmann, I., Muller-Newen, G., Schaper, F. & Graeve, L. Interleukin-6-Type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 334 (Pt2), 297-314 (1998
    • (1998) Biochem. J. , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 36
    • 0346103717 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of il-10 in human macrophages
    • Williams, L., Bradley, L., Smith, A. & Foxwell, B. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J. Immunol. 172, 567-576 (2004
    • (2004) J. Immunol , vol.172 , pp. 567-576
    • Williams, L.1    Bradley, L.2    Smith, A.3    Foxwell, B.4
  • 37
    • 33646595287 scopus 로고    scopus 로고
    • Ifn-gamma suppresses il-10 production and synergizes with tlr2 by regulating gsk3 and creb/ap-1 proteins
    • Hu, X., et al. IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity 24, 563-574 (2006
    • (2006) Immunity , vol.24 , pp. 563-574
    • Hu, X.1
  • 38
    • 34249826961 scopus 로고    scopus 로고
    • Cutting edge: Involvement of the type i ifn production and signaling pathway in lipopolysaccharide-induced il-10 production
    • Chang, E. Y., Guo, B., Doyle, S. E. & Cheng, G. Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J. Immunol. 178, 6705-6709 (2007
    • (2007) J. Immunol , vol.178 , pp. 6705-6709
    • Chang, E.Y.1    Guo, B.2    Doyle, S.E.3    Cheng, G.4
  • 39
    • 0034085912 scopus 로고    scopus 로고
    • Opposing actions of stat-1 and stat-3 on the bcl-2 and bcl-x promoters
    • Stephanou, A., Brar, B. K., Knight, R. A. & Latchman, D. S. Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters. Cell Death Differ. 7, 329-330 (2000
    • (2000) Cell Death Differ , vol.7 , pp. 329-330
    • Stephanou, A.1    Brar, B.K.2    Knight, R.A.3    Latchman, D.S.4
  • 40
    • 52949136974 scopus 로고    scopus 로고
    • Ups and downs: The stat1: Stat3 seesaw of interferon and gp130 receptor signalling
    • Regis, G., Pensa, S., Boselli, D., Novelli, F. & Poli, V. Ups and downs: the STAT1: STAT3 seesaw of Interferon and gp130 receptor signalling. Semin. Cell Dev. Biol. 19, 351-359 (2008
    • (2008) Semin. Cell Dev. Biol , vol.19 , pp. 351-359
    • Regis, G.1    Pensa, S.2    Boselli, D.3    Novelli, F.4    Poli, V.5
  • 41
    • 0036854891 scopus 로고    scopus 로고
    • Opposing roles of stat1 and stat3 in t cell-mediated hepatitis: Regulation by socs
    • Hong, F., et al. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J. Clin. Invest. 110, 1503-1513 (2002
    • (2002) J. Clin. Invest , vol.110 , pp. 1503-1513
    • Hong, F.1
  • 42
    • 0033104946 scopus 로고    scopus 로고
    • Interleukin-10 inhibits expression of both interferon alpha-And interferon gamma-induced genes by suppressing tyrosine phosphorylation of stat1
    • Ito, S., et al. Interleukin-10 inhibits expression of both interferon alpha-And interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1. Blood 93, 1456-1463 (1999
    • (1999) Blood , vol.93 , pp. 1456-1463
    • Ito, S.1
  • 43
    • 4744364574 scopus 로고    scopus 로고
    • Alternative activation of stat1 and stat3 in response to interferon-gamma
    • Qing, Y. & Stark, G. R. Alternative activation of STAT1 and STAT3 in response to interferon-gamma. J. Biol. Chem. 279, 41679-41685 (2004
    • (2004) J. Biol. Chem , vol.279 , pp. 41679-41685
    • Qing, Y.1    Stark, G.R.2
  • 44
    • 0037062503 scopus 로고    scopus 로고
    • Mutational switch of an il-6 response to an interferon-gamma-like response
    • Costa-Pereira, A. P., et al. Mutational switch of an IL-6 response to an interferon-gamma-like response. Proc. Natl. Acad. Sci. USA 99, 8043-8047 (2002
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8043-8047
    • Costa-Pereira, A.P.1
  • 45
    • 0026081695 scopus 로고
    • Mechanisms and modulation of macrophage activation
    • Nathan, C. Mechanisms and modulation of macrophage activation. Behring Inst. Mitt. 200-207 (1991
    • (1991) Behring Inst. Mitt , pp. 200-207
    • Nathan, C.1
  • 46
    • 0037310024 scopus 로고    scopus 로고
    • The many faces of macrophage activation
    • Mosser, D. M. The many faces of macrophage activation. J. Leukoc. Biol. 73, 209-212 (2003
    • (2003) J. Leukoc. Biol , vol.73 , pp. 209-212
    • Mosser, D.M.1
  • 47
    • 0036797750 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 (stat3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappab
    • Yu, Z., Zhang, W. & Kone, B. C. Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem. J. 367, 97-105 (2002
    • (2002) Biochem. J. , vol.367 , pp. 97-105
    • Yu, Z.1    Zhang, W.2    Kone, B.C.3
  • 48
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated stat3 maintains constitutive nf-kappab activity in tumors
    • Lee, H., et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15, 283-293 (2009
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1
  • 49
    • 33646591224 scopus 로고    scopus 로고
    • Stat3 activation of nf-? B p100 processing involves cbp/p300-mediated acetylation
    • Nadiminty, N., et al. Stat3 activation of NF-? B p100 processing involves CBP/p300-mediated acetylation. Proc. Natl. Acad. Sci. USA 103, 7264-7269 (2006
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 7264-7269
    • Nadiminty, N.1
  • 50
    • 84907029151 scopus 로고    scopus 로고
    • Noncanonical nf-kappab activation mediates stat3-stimulated ido upregulation in myeloid-derived suppressor cells in breast cancer
    • Yu, J., et al. Noncanonical NF-kappaB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer. J. Immunol. 193, 2574-2586 (2014
    • (2014) J. Immunol , vol.193 , pp. 2574-2586
    • Yu, J.1
  • 51
    • 2542478996 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signaling (socs) proteins in regulation of the immune response
    • Alexander, W. S. & Hilton, D. J. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu. Rev. Immunol. 22, 503-529 (2004
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 503-529
    • Alexander, W.S.1    Hilton, D.J.2
  • 52
    • 0032567353 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling (socs) 1 and socs3 but not socs2 proteins inhibit interferonmediated antiviral and antiproliferative activities
    • Song, M. M. & Shuai, K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferonmediated antiviral and antiproliferative activities. J. Biol. Chem. 273, 35056-35062 (1998
    • (1998) J. Biol. Chem , vol.273 , pp. 35056-35062
    • Song, M.M.1    Shuai, K.2
  • 53
    • 84865298775 scopus 로고    scopus 로고
    • Dissecting negative regulation of toll-like receptor signaling
    • Kondo, T., Kawai, T. & Akira, S. Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol. 33, 449-458 (2012
    • (2012) Trends Immunol , vol.33 , pp. 449-458
    • Kondo, T.1    Kawai, T.2    Akira, S.3
  • 54
    • 0033535958 scopus 로고    scopus 로고
    • Autoregulation of pituitary corticotroph socs-3 expression: Characterization of the murine socs-3 promoter
    • Auernhammer, C. J., Bousquet, C. & Melmed, S. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc. Natl. Acad. Sci. USA 96, 6964-6969 (1999
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6964-6969
    • Auernhammer, C.J.1    Bousquet, C.2    Melmed, S.3
  • 55
    • 84884675857 scopus 로고    scopus 로고
    • Pivotal roles of cgas-cgamp signaling in antiviral defense and immune adjuvant effects
    • Li, X. D., et al. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341, 1390-1394 (2013
    • (2013) Science , vol.341 , pp. 1390-1394
    • Li, X.D.1
  • 56
    • 80051876588 scopus 로고    scopus 로고
    • Severe impairment of ifn-gamma and ifn-Alpha responses in cells of a patient with a novel stat1 splicing mutation
    • Vairo, D., et al. Severe impairment of IFN-gamma and IFN-Alpha responses in cells of a patient with a novel STAT1 splicing mutation. Blood 118, 1806-1817 (2011
    • (2011) Blood , vol.118 , pp. 1806-1817
    • Vairo, D.1
  • 57
    • 0033998608 scopus 로고    scopus 로고
    • Microarray analysis identifies interferon-inducible genes and stat-1 as major transcriptional targets of human papillomavirus type 31
    • Chang, Y. E. & Laimins, L. A. Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31. J. Virol. 74, 4174-4182 (2000
    • (2000) J. Virol , vol.74 , pp. 4174-4182
    • Chang, Y.E.1    Laimins, L.A.2
  • 58
    • 0034800768 scopus 로고    scopus 로고
    • C terminal cys-rich region of mumps virus structural v protein correlates with block of interferon alpha and gamma signal transduction pathway through decrease of stat 1-Alpha
    • Kubota, T., Yokosawa, N., Yokota, S. & Fujii, N. C terminal CYS-RICH region of mumps virus structural V protein correlates with block of interferon alpha and gamma signal transduction pathway through decrease of STAT 1-Alpha. Biochem. Biophys. Res. Commun. 283, 255-259 (2001
    • (2001) Biochem. Biophys. Res. Commun , vol.283 , pp. 255-259
    • Kubota, T.1    Yokosawa, N.2    Yokota, S.3    Fujii, N.4
  • 59
    • 22544482621 scopus 로고    scopus 로고
    • Essential role of stat1 in caspase-independent cell death of activated macrophages through the p38 mitogen-Activated protein kinase/stat1/reactive oxygen species pathway
    • Kim, H. S. & Lee, M. S. Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-Activated protein kinase/STAT1/reactive oxygen species pathway. Mol. Cell. Biol. 25, 6821-6833 (2005
    • (2005) Mol. Cell. Biol , vol.25 , pp. 6821-6833
    • Kim, H.S.1    Lee, M.S.2
  • 60
    • 58849167699 scopus 로고    scopus 로고
    • The isolation and characterization of murine macrophages
    • Chapter 14 Unit 14.1.1
    • Zhang, X., Goncalves, R. & Mosser, D. M. The isolation and characterization of murine macrophages. Curr. Protoc. Immunol. Chapter 14, Unit 14.1.1 (2008
    • (2008) Curr. Protoc. Immunol
    • Zhang, X.1    Goncalves, R.2    Mosser, D.M.3
  • 61
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an irf3-dependent innate immune response
    • Stetson, D. B. & Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24, 93-103 (2006
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 62
    • 84860342878 scopus 로고    scopus 로고
    • A defect in cell death of macrophages is a conserved feature of nonobese diabetic mouse
    • Kim, H. S., Park, J. M. & Lee, M. S. A defect in cell death of macrophages is a conserved feature of nonobese diabetic mouse. Biochem. Biophys. Res. Commun. 421, 145-151 (2012
    • (2012) Biochem. Biophys. Res. Commun , vol.421 , pp. 145-151
    • Kim, H.S.1    Park, J.M.2    Lee, M.S.3
  • 63
    • 65649142558 scopus 로고    scopus 로고
    • The expression of exogenous genes in macrophages: Obstacles and opportunities
    • Zhang, X., Edwards, J. P. & Mosser, D. M. The expression of exogenous genes in macrophages: obstacles and opportunities. Methods Mol. Biol. 531, 123-143 (2009
    • (2009) Methods Mol. Biol , vol.531 , pp. 123-143
    • Zhang, X.1    Edwards, J.P.2    Mosser, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.