Interferon-modulated expression of genes encoding the nuclear-dot-associated proteins Sp100 and promyelocytic leukemia protein (PML)

European Journal of Biochemistry

Volumn 238, Issue 2, 1996, Pages 554-560

  Grötzinger, Thilo ^a   Sternsdorf, Thomas ^a   Jensen, Kirsten ^a   Will, Hans ^a,b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

acute promyelocytic leukemia; interferon; interferon stimulated genes; nuclear dots; Sp100

Indexed keywords

BETA INTERFERON; CELL PROTEIN; GAMMA INTERFERON; INTERFERON; MESSENGER RNA; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN SP 100; UNCLASSIFIED DRUG;

ARTICLE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION;

EID: 0029894340     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0554z.x     Document Type: Article

References (44)

1. Joklik, W. K. (1990) Interferons, in Virology (Fields, B. N. & Knipe, D. M., eds) 2nd edn, pp. 383-410, Raven Press, New York.
2. Revel, M. & Chebath, J. (1986) Interferon-activated genes, Trends Biochem. Sci. 11, 166-170.
3. Darnell, J. E. Jr, Kerr, I. M. & Stark, G. R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science 264, 1415-1421.
4. Müller, M., Ibelgaufts, H. & Kerr, I. M. (1994) Interferon response pathways - a paradigm for cytokine signalling? J. Viral Hepatitis 1, 87-103.
5. Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., Thierfelder, W. E., Kreider, B. & Silvennoinen, O. (1994) Signaling by the cytokine receptor superfamily: JAKs and STATs, Trends Biochem. Sci. 19, 222-227.
6. Guldner, H. H., Szostecki, C., Grötzinger, T. & Will, H. (1992) IFN enhance expression of Sp100, an autoantigen in primary biliary cirrhosis, J. Immunol. 149, 4067-4073.
7. Maul, G. G., Guldner, H. H. & Spivack, J. G. (1993) Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0), J. Gen. Virol. 74, 2679-2690.
8. Szostecki, C., Krippner, H., Penner, E. & Bautz, F. A. (1987) Autoimmune sera recognize a 100 kD nuclear protein antigen (sp-100), Clin. Exp. Immunol. 68, 108-116.
9. Szostecki, C., Guldner, H. H., Netter, H. J. & Will, H. (1990) Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis, J. Immunol. 145, 4338-4347.
10. Szostecki, C., Will, H., Netter, H. J. & Guldner, H. H. (1992) Autoantibodies to the nuclear Sp100 protein in primary biliary cirrhosis: epitope specificity and immunoglobulin class distribution, Scand. J. Immunol. 36, 555-564.
11. Sternsdorf, T., Guldner, H. H., Szostecki, C., Grötzinger, T. & Will, H. (1995) Two nuclear dot-associated proteins, PML and Sp100, are often co-autoimmunogenic in patients with primary biliary cirrhosis, Scand. J. Immunol. 42, 257-268.
12. Ascoli, C. A. & Maul, G. G. (1991) Identification of a novel nuclear domain, J. Cell Biol. 112, 785-795.
13. Xie, K., Lambie, E. J. & Snyder, M. (1993) Nuclear dot antigens may specify transcriptional domains in the nucleus, Mol. Cell. Biol. 13, 6170-6179.
14. Korioth, F., Gieffers, C., Maul, G. G. & Frey, J. (1995) Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment, J. Cell Biol. 130, 1-13.
15. Koken, M. H. M., Puvion-Dutilleul, F., Guillemin, M. C., Viron, A., Linares-Cruz, G., Stuurman, N., de Jong, L., Szostecki, C., Calvo, F., Chomienne, C., Degos, L., Puvion, E. & de Thé, H. (1994) The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion, EMBO J. 13, 1073-1083.
16. Weis, K., Rambaud, S., Lavau, C., Jansen, J., Carvalho, T., Carmo-Fonseca, M., Lamond, A. & Dejean, A. (1994) Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells, Cell 76, 345-356.
17. Dyck, J. A., Maul, G. G., Miller, W. H. Jr, Chen, J. D., Kakizuka, A. & Evans, R. M. (1994) A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein, Cell 76, 333-343.
18. Terris, B., Baldin, V., Dubois, S., Degott, C., Flejou, J.-F., Hénin, D. & Dejean, A. (1995) PML nuclear bodies are general targets for inflammation and cell proliferation, Cancer Res. 55, 1590-1597.
19. Mu, Z.-M., Chin, K.-V., Liu, J.-H., Lozano, G. & Chang, K.-S. (1994) PML, a growth suppressor disrupted in acute promyelocytic leukemia, Mol. Cell. Biol. 14, 6858-6867.
20. Liu, J.-H., Mu, Z.-M. & Chang, K.-S. (1995) PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu, J. Exp. Med. 181, 1965-1973.
21. Koken, M. H. M., Linares-Cruz, G., Quignon, F., Viron, A., Chelbi-Alix, M. K., Sobczak-Thépot, J., Juhlin, L., Degos, L., Calvo, F. & de Thé, H. (1995) The PML growth-suppressor has an altered expression in human oncogenesis, Oncogene 10, 1315-1324.
22. Kakizuka, A., Miller, W. H. Jr, Umesono, K., Warrell, R. P. Jr, Frankel, S. R., Murty, V. V. V. S., Dmitrovsky, E. & Evans, R. M. (1991) Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML, Cell 66, 663-674.
23. de Thé, H., Chomienne, C., Lanotte, M., Degos, L. & Dejean, A. (1990) The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus, Nature 347, 558-561.
24. Puvion-Dutilleul, F., Chelbi-Alix, M. K., Koken, M. H. M., Quignon, F., Puvion, E. & de Thé, H. (1995) Adenovirus infection induces rearrangements in the intranuclear distribution of the nuclear body-associated PML protein, Exp. Cell Res. 218, 9-16.
25. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular cloning - a laboratory manual, 2nd edn, Cold Spring Harbor Laboratory Press, Cold Spring Habor, NY.
26. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-685.
27. Towbin, H., Staehelin, T. & Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, Proc. Natl Acad. Sci. USA 76, 4350-4354.
28. Harlow, E. & Lane, D. (1988) Antibodies - a laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. Greenberg, M. E. & Bender, T. P. (1990) Identification of newly transcribed RNA, in Current protocols in molecular biology (Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K., eds) pp. 4.10.1-4.10.9, John Wiley & Sons, New York.
30. Fei, H. & Drake, T. A. (1993) A rapid nuclear runoff transcription assay, Biotechniques 75, 838.
31. Cheng, Y.-S. E., Patterson, C. E. & Staeheli, P. (1991) Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP, Mol. Cell. Biol. 11, 4717-4725.
32. Tso, J. Y., Sun, X.-H., Kao, T.-H., Reece, K. S. & Wu, R. (1985) Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene, Nucleic Acids Res. 13, 2485-2502.
33. Gunning, P., Ponte, P., Okayama, H., Engel, J., Blau, H. & Kedes, L. (1983) Isolation and characterization of full-length cDNA clones for human α-, β-, and γ-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed, Mol. Cell. Biol. 3, 787-795.
34. de Thé, H., Lavau, C., Marchio, A., Chomienne, C., Degos, L. & Dejean, A. (1991) The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR, Cell 66, 675-684.
35. Fagioli, M., Alcalay, M., Pandolfi, P. P., Venturini, L., Mencarelli, A., Simeone, A., Acampora, D., Grignani, F. & Pelicci, P. G. (1992) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms, Oncogene 7, 1083-1091.
36. Pandolfi, P. P., Alcalay, M., Fagioli, M., Zangrilli, D., Mencarelli, A., Diverio, D., Biondi, A., Lo Coco, F., Rambaldi, A., Grignani, F., Rochette-Egly, C., Gaube, M.-P., Chambon, P. & Pelicci, P. G. (1992) Genomic variability and alternative splicing generate multiple PML/RARα transcripts that encode aberrant PML proteins and PML/RARα isoforms in acute promyelocytic leukaemia, EMBO J. 11, 1397-1407.
37. Lew, D. J., Decker, T. & Darnell, J. E. Jr (1989) Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways, Mol. Cell. Biol. 9, 5404-5411.
38. Levy, D. E., Lew, D. J., Decker, T., Kessler, D. S. & Darnell, J. E. Jr (1990) Synergistic interaction between interferon-α and interferon-γ through induced synthesis of one subunit of the transcription factor ISGF3, EMBO J. 9, 1105-1111.
39. Flenghi, L., Fagioli, M., Tomassoni, L., Pileri, S., Gambacorta, M., Pacini, R., Grignani, F., Casini, T., Ferrucci, P. F., Martelli, M. F., Pelicci, P.-G. & Falini, B. (1995) Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia, Blood 85, 1871-1880.
40. Daniel, M. T., Koken, M., Romagné, O., Barbey, S., Bazarbachi, A., Stadler, M., Guillemin, M. C., Degos, L., Chomienne, C. & de Thé, H. (1993) PML protein expression in hematopoietic and acute promyelocytic leukemia cells, Blood 82, 1858-1867.
41. Giles, F. J. & Ozer, H. (1991) α-Interferon in hematological malignancies, Curr. Opin. Biotechnol. 2, 847-850.
42. Friedman, R. L., Manly, S. P., McMahon, M., Kerr, I. M. & Stark, G. R. (1984) Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells, Cell 38, 745-755.
43. Ackrill, A. M., Reid, L. E., Gilbert, C. S., Gewert, D. R., Porter, A. C. G., Lewin, A. R., Stark, G. R. & Kerr, I. M. (1991) Differential response of the human 6-16 and 9-27 genes to α and γ interferons, Nucleic Acids Res. 19, 591-598.
44. Guille, M. J., Laxton, C. D., Rutherford, M. N., Williams, B. R. G. & Kerr, I. M. (1994) Functional differences in the promoters of the interferon-inducible (2′-5′)A oligoadenylate synthetase and 6-16 genes in interferon-resistant Daudi cells, Eur. J. Biochem. 219, 547-553.