PIAS proteins promote SUMO-1 conjugation to STAT1

Blood

Volumn 102, Issue 9, 2003, Pages 3311-3313

  Ungureanu, Daniela ^b   Vanhatupa, Sari ^b   Kotaja, Noora ^b   Yang, Jie ^b   Aittomäki, Saara ^b   Jänne, Olli A ^b   Palvimo, Jorma J ^b   Silvennoinen, Olli ^a  

^a UNIVERSITY OF TAMPERE   (Finland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INHIBITOR PROTEIN; LIGASE; LYSINE; PERVANADATE; PROTEIN INHIBITOR OF ACTIVATED STAT; PROTEIN INHIBITOR OF ACTIVATED STAT1; STAT1 PROTEIN; SUMO 1 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CELL STRAIN COS7; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; SUMOYLATION; TRANSACTIVATION;

EID: 0142152429     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-12-3816     Document Type: Article

References (21)

1. Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002;3:651-662.
2. O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 2002;109:S121-S131.
3. Liu B, Liao J, Rao X, et al. Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A. 1998;95:10626-10631.
4. Chung CD, Liao J, Liu B, et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997;278:1803-1805.
5. Liao J, Fu Y, Shuai K. Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. Proc Natl Acad Sci U S A. 2000;97:5267-5272.
6. Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA. ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. Mol Endocrinol. 2000;14:1986-2000.
7. Wu L, Wu H, Ma L, et al. Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev. 1997;65: 3-17.
8. Tan JA, Hall SH, Hamil KG, Grossman G, Petrusz P, French FS. Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators. J Biol Chem. 2002;277:16993-17001.
9. Kotaja N, Karvonen U, Jänne OA, Palvimo JJ. PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol Cell Biol. 2002;22:5222-5234.
10. Johnson ES, Gupta AA. An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell. 2001;106:735-744.
11. Takahashi Y, Kahyo T, Toh EA, Yasuda H, Kikuchi Y. Yeast UII1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J Biol Chem. 2001;276:48973-48977.
12. Sachdev S, Bruhn L, Sieber H, Pichler A, Melchior F, Grosschedl R. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 2001;15:3088-3103.
13. Melchior F. SUMO-nonclassical ubiquitin. Annu Rev Cell Dev Biol. 2000;16:591-626.
14. Schmidt D, Muller S. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc Natl Acad Sci U S A. 2002;99:2872-2877.
15. Kahyo T, Nishida T, Yasuda H. Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol Cell. 2001;8:713-718.
16. Aittomäki S, Pesu M, Groner B, Jänne OA, Palvimo JJ, Silvennoinen O. Cooperation among Statl, glucocorticoid receptor, and PU.1 in transcriptional activation of the high-affinity Fc gamma receptor I in monocytes. J Immunol. 2000;164:5689-5697.
17. Kotaja N, Vihinen M, Palvimo JJ, Jänne OA. Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signaling. J Biol Chem. 2002;277: 17781-17788.
18. Rogers RS, Horvath CM, Matunis MJ. SUMO modification of STAT1 and its role in PIAS-meditated inhibition of gene activation. J Biol Chem. 2003;278:30091-30097.
19. Nakagawa K, Yokosawa H. PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1. FEBS Lett. 2002;530:204-208.
20. Zhang JJ, Zhao Y, Chait BT, et al. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J. 1998;17:6963-6971.
21. Kim TK, Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science. 1996;273:1717-1719.