The serotonin receptor 6 antagonist idalopirdine and acetylcholinesterase inhibitor donepezil have synergistic effects on brain activity-a functional MRI study in the awake rat

Frontiers in Pharmacology

Volumn 8, Issue JUN, 2017, Pages

  Ferris, Craig F ^a   Kulkarni, Praveen ^a   Yee, Jason R ^a   Nedelman, Mark ^b   de Jong, Inge E M ^c  

^a NORTHEASTERN UNIVERSITY   (United States)

^b Ekam Imaging   (United States)

^c H LUNDBECK A S   (Denmark)

Author keywords

Acetylcholine; Alzheimer's disease; BOLD fMRI; Cognition; Serotonin

Indexed keywords

CHOLINESTERASE INHIBITOR; DONEPEZIL; IDALOPIRDINE; NEUROTRANSMITTER; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST;

AMYGDALA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BOLD SIGNAL; BRAIN DEPTH STIMULATION; BRAIN ELECTROPHYSIOLOGY; BRAIN REGION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DIAGONAL BAND OF BROCA; DRUG EFFECT; DRUG POTENTIATION; FOREBRAIN; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GLOBUS PALLIDUS; HIPPOCAMPUS; INFRALIMBIC CORTEX; MALE; NERVE CELL NETWORK; NONHUMAN; NUCLEUS ACCUMBENS SHELL; PREOPTIC AREA; RAPHE NUCLEUS; RAT; SEROTONINERGIC SYSTEM; SINGLE DRUG DOSE; VENTRAL PALLIDUM;

EID: 85020739982     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2017.00279     Document Type: Article

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