Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI

Journal of Magnetic Resonance Imaging

Volumn 34, Issue 4, 2011, Pages 764-773

  Goveas, Joseph S ^a   Xie, Chunming ^a,b   Ward, B Douglas ^a   Wu, Zhilin ^a   Li, Wenjun ^a   Franczak, Malgorzata ^a   Jones, Jennifer L ^a   Antuono, Piero G ^a   Li, Shi Jiang ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

Alzheimer's disease; donepezil; hippocampus; resting state functional MRI

Indexed keywords

DONEPEZIL;

AGED; ALZHEIMER DISEASE; ALZHEIMER DISEASE ASSESSMENT SCALE; ARTICLE; BEHAVIOR CHANGE; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DRUG DOSE INCREASE; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HIPPOCAMPUS FUNCTIONAL CONNECTIVITY; HUMAN; INFERIOR FRONTAL GYRUS; INSTRUMENTAL ACTIVITIES OF DAILY LIVING SCALE; LEFT HEMISPHERE; MALE; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NEUROPSYCHIATRIC INVENTORY; NEUROPSYCHOLOGICAL TEST; PARAHIPPOCAMPAL GYRUS; PREFRONTAL CORTEX; PRIORITY JOURNAL; RATING SCALE; REST; TEMPORAL LOBE; TREATMENT OUTCOME; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; COGNITION DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HIPPOCAMPUS; HUMANS; INDANS; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MALE; NERVE NET; NEUROPSYCHOLOGICAL TESTS; PIPERIDINES; RECOVERY OF FUNCTION; REFERENCE VALUES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 80052982355     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.22662     Document Type: Article

References (41)

1. Mesulam M,. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show? Learn Mem 2004; 11: 43-49. (Pubitemid 38167057)
2. Bartus RT, Dean RL 3rd, Beer B, Lippa AS,. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982; 217: 408-414.
3. Coyle JT, Price DL, DeLong MR,. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 1983; 219: 1184-1190. (Pubitemid 13160659)
4. Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT,. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 1998; 50: 136-145.
5. Jacobson SA, Sabbagh MN,. Donepezil: potential neuroprotective and disease-modifying effects. Expert Opin Drug Metab Toxicol 2008; 4: 1363-1369.
6. Kaduszkiewicz H, Zimmermann T, Beck-Bornholdt HP, van den Bussche H,. Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomized clinical trials. BMJ 2005; 331: 321-327.
7. Venneri A,. Imaging treatment effects in Alzheimer's disease. Magn Reson Imaging 2007; 25: 953-968. (Pubitemid 47081351)
8. Rombouts SA, Barkhof F, Van Meel CS, Scheltens P,. Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2002; 73: 665-671. (Pubitemid 35448850)
9. Goekoop R, Rombouts SA, Jonker C, et al. Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study. Neuroimage 2004; 23: 1450-1459. (Pubitemid 40260368)
10. Saykin AJ, Wishart HA, Rabin LA, et al. Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. Brain 2004; 127: 1574-1583. (Pubitemid 38899410)
11. Kircher TT, Erb M, Grodd W, Leube DT,. Cortical activation during cholinesterase-inhibitor treatment in Alzheimer disease: preliminary findings from a pharmaco-fMRI study. Am J Geriatr Psychiatry 2005; 13: 1006-1013. (Pubitemid 46638668)
12. Shanks MF, McGeown WJ, Forbes-McKay KE, Waiter GD, Ries M, Venneri A,. Regional brain activity after prolonged cholinergic enhancement in early Alzheimer's disease. Magn Reson Imaging 2007; 25: 848-859. (Pubitemid 47081360)
13. McGeown WJ, Shanks MF, Venneri A,. Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer's disease. Neuropsychiatr Dis Treat 2008; 4: 465-476. (Pubitemid 351711940)
14. Petrella JR, Prince SE, Krishnan S, Husn H, Kelley L, Doraiswamy PM,. Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging. AJNR Am J Neuroradiol 2009; 30: 411-416.
15. Gould RL, Brown RG, Owen AM, Bullmore ET, Williams SC, Howard RJ,. Functional neuroanatomy of successful paired associate learning in Alzheimer's disease. Am J Psychiatry 2005; 162: 2049-2060. (Pubitemid 41598258)
16. Lakmache Y, Lassonde M, Gauthier S, Frigon JY, Lepore F,. Interhemispheric disconnection syndrome in Alzheimer's disease. Proc Natl Acad Sci U S A 1998; 95: 9042-9046. (Pubitemid 28350611)
17. Grady CL, Furey ML, Pietrini P, Horwitz B, Rapoport SI,. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain 2001; 124: 739-756. (Pubitemid 32303833)
18. Li SJ, Li Z, Wu G, Zhang MJ, Franczak M, Antuono PG,. Alzheimer disease: evaluation of a functional MR imaging index as a marker. Radiology 2002; 225: 253-259.
19. Greicius MD, Srivastava G, Reiss AL, Menon V,. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A 2004; 101: 4637-4642. (Pubitemid 38437463)
20. Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 2005; 25: 7709-7717. (Pubitemid 41208641)
21. Buckner RL, Sepulcre J, Talukdar T, et al. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci 2009; 29: 1860-1873.
22. Wang L, Zang Y, He Y, et al. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI. Neuroimage 2006; 31: 496-504. (Pubitemid 43776683)
23. Allen G, Barnard H, McColl R, et al. Reduced hippocampal functional connectivity in Alzheimer disease. Arch Neurol 2007; 64: 1482-1487. (Pubitemid 47572671)
24. Wang K, Liang M, Wang L, et al. Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study. Hum Brain Mapp 2007; 28: 967-978. (Pubitemid 47549702)
25. Xu Y, Xu G, Wu G, Antuono P, Rowe DB, Li SJ,. The phase shift index for marking functional asynchrony in Alzheimer's disease patients using fMRI. Magn Reson Imaging 2008; 26: 379-392.
26. Biswal B, Yetkin FZ, Haughton VM, Hyde JS,. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 1995; 34: 537-541.
27. Fox MD, Raichle ME,. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 2007; 8: 700-711. (Pubitemid 47283145)
28. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM,. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944. (Pubitemid 14076461)
29. Xu G, Antuono PG, Jones J, et al. Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects. Neurology 2007; 69: 1650-1656. (Pubitemid 350287120)
30. Glover GH, Li TQ, Ress D,. Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR. Magn Reson Med 2000; 44: 162-7.31.
31. Birn RM, Murphy K, Bandettini PA,. The effect of respiration variations on independent component analysis results of resting state functional connectivity. Hum Brain Mapp 2008; 29: 740-50.30.
32. Rombouts SA, Stam CJ, Kuijer JP, Scheltens P, Barkhof F,. Identifying confounds to increase specificity during a "no task condition" evidence for hippocampal connectivity using fMRI. Neuroimage 2003; 20: 1236-1245. (Pubitemid 37268141)
33. Orfanidis SJ,. Introduction to signal processing. Upper Saddle River, NJ: Prentice Hall; 1996.
34. Zar JH,. Biostatistical analysis, 3rd ed. Upper Saddle River, NJ: Prentice-Hall; 1996.
35. Mesulam M-M,. Central cholinergic pathways: neuroanatomy and some behavioral implications. In:, Avoli M, Reader TA, Dykes RW, Gloor P, editors. Neurotransmitters and cortical function. New York: Plenum Press; 1988. p 237-260.
36. Okamura N, Funaki Y, Tashiro M, et al. In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease. Br J Clin Pharmacol 2008; 65: 472-479. (Pubitemid 351365133)
37. Greicius MD, Krasnow B, Reiss AL, Menon V,. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A 2003; 100: 253-258. (Pubitemid 36078061)
38. Hagmann P, Cammoun L, Gigandet X, et al. Mapping the structural core of human cerebral cortex. PLoS Biol 2008; 6: e159: 1479-1493.
39. Euston DR, Tatsuno M, McNaughton BL,. Fast-forward playback of recent memory sequences in prefrontal cortex during sleep. Science 2007; 318: 1147-1150. (Pubitemid 350134899)
40. Sorg C, Riedl V, Mühlau M, et al. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci U S A 2007; 104: 18760-18765. (Pubitemid 350210770)
41. Seltzer B, Zolnouni P, Nunez M, et al. Donepezil "402" Study Group. Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial. Arch Neurol 2004; 61: 1852-1856. (Pubitemid 39612945)