Positron emission tomography metabolic correlates of apathy in Alzheimer disease

Archives of Neurology

Volumn 64, Issue 7, 2007, Pages 1015-1020

  Marshall, Gad A ^a   Monserratt, Lorena ^c   Harwood, Dylan ^b,c   Mandelkern, Mark ^c,d,e   Cummings, Jeffrey L ^a,b   Sultzer, David L ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

AGED; ALZHEIMER DISEASE; APATHY; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; FEMALE; HUMAN; MALE; METABOLIC RATE; NEUROIMAGING; NEUROPSYCHIATRY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; STATISTICAL SIGNIFICANCE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; ENERGY METABOLISM; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCOSE; GYRUS CINGULI; HUMANS; MALE; MOOD DISORDERS; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PREFRONTAL CORTEX; THALAMUS;

EID: 34447260479     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.64.7.1015     Document Type: Article

References (25)

1. Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. 2000;157(5):708-714.
2. Mega MS, Cummings JL, Fiorello T, Gornbein J. The spectrum of behavioral changes in Alzheimer's disease. Neurology. 1996;46(1):130-135.
3. Starkstein SE, Petracca G, Chemerinski E, Kremer J. Syndromic validity of apathy in Alzheimer's disease. Am J Psychiatry. 2001;158(6):872-877.
4. Kuzis G, Sabe L, Tiberti C, Dorrego F, Starkstein SE. Neuropsychological correlates of apathy and depression in patients with dementia. Neurology. 1999;52(7):1403-1407.
5. McPherson S, Fairbanks L, Tiken S, Cummings JL, Back-Madruga C. Apathy and executive function in Alzheimer's disease. J Int Neuropsychol Soc. 2002;8(3):373-381.
6. Benoit M, Clairet S, Koulibaly PM, Darcourt J, Robert PH. Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease. Int J Geriatr Psychiatry. 2004;19(9):864-869.
7. Migneco O, Benoit M, Koulibaly PM, et al. Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients. Neuroimage. 2001;13(5):896-902.
8. Craig AH, Cummings JL, Fairbanks L, et al. Cerebral blood flow correlates of apathy in Alzheimer disease. Arch Neurol. 1996;53(11):1116-1120.
9. Ott BR, Noto RB, Fogel BS. Apathy and loss of insight in Alzheimer's disease: a SPECT imaging study. J Neuropsychiatry Clin Neurosci. 1996;8(1):41-46.
10. Cummings JL, Apostolova LG, Akopyan GG, et al. Structural correlates of apathy in Alzheimer's disease [abstract]. Neurology. 2006;66(5)(suppl 2):A105.
11. Marshall GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL. Neuropathologic correlates of apathy in Alzheimer's disease. Dement Geriatr Cogn Disord. 2006;21(3):144-147.
12. Tekin S, Mega MS, Masterman DM, et al. Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease. Ann Neurol. 2001;49(3):355-361.
13. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939-944.
14. Reichman WE, Coyne AC, Amirneni S, Molino B Jr, Egan S. Negative symptoms in Alzheimer's disease. Am J Psychiatry. 1996;153(3):424-426.
15. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198.
16. Sultzer DL, Berisford MA, Gunay I. The Neurobehavioral Rating Scale: reliability in patients with dementia. J Psychiatr Res. 1995;29(3):185-191.
17. Hamacher K, Coenen HH, Stocklin G. Efficient stereospecific synthesis of nocarrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986;27(2):235-238.
18. Talairach J, Tournoux P. Co-Planar Stereotactic Atlas of the Human Brain 3-Dimensional Proportional System: An Approach to Cerebral Imaging. New York, NY: Thieme Medical; 1988.
19. Cummings JL. Frontal-subcortical circuits and human behavior. Arch Neurol. 1993;50(8):873-880.
20. Cummings JL. The Neuropsychiatry of Alzheimer's Disease and Related Dementias. London, England: Martin Dunitz; 2003.
21. Mega MS, Cummings JL, Salloway S, Malloy P. The limbic system: an anatomic, phylogenetic, and clinical perspective. J Neuropsychiatry Clin Neurosci. 1997;9(3):315-330.
22. Feldman H, Gauthier S, Hecker J, et al. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology. 2001;57(4):613-620.
23. Wynn ZJ, Cummings JL. Cholinesterase inhibitor therapies and neuropsychiatric manifestations of Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;17(1-2):100-108.
24. Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005;128(pt 11):2612-2625.
25. Levy ML, Cummings JL, Fairbanks LA, et al. Apathy is not depression. J Neuropsychiatry Clin Neurosci. 1998;10(3):314-319.