Microvascular BOLD contribution at 4 and 7 T in the human brain: Gradient-echo and spin-echo fMRI with suppression of blood effects

Magnetic Resonance in Medicine

Volumn 49, Issue 6, 2003, Pages 1019-1027

  Duong, Timothy Q ^a,b   Yacoub, Essa ^a   Adriany, Gregory ^a   Hu, Xiaoping ^a,c   Uǧurbil, Kâmil ^a   Kim, Seong Gi ^a,d  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c EMORY UNIVERSITY   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Brain mapping; Diffusion weighting; High magnetic fields; Spatial specificity

Indexed keywords

BLOOD; BLOOD VESSELS; BRAIN MAPPING; MAPPING; SPIN POLARIZATION; TISSUE;

DIFFUSION GRADIENTS; DIFFUSION WEIGHTING; FIELD STRENGTHS; HIGH MAGNETIC FIELDS; HUMAN VISUAL CORTEX; MICRO-VASCULATURE; RELATIVE CONTRIBUTION; SPATIAL SPECIFICITY;

ECHO SUPPRESSION;

ADULT; ARTICLE; BLOOD OXYGENATION; BRAIN BLOOD FLOW; CONTRAST ENHANCEMENT; ELECTRON SPIN RESONANCE; EXTRAVASCULAR SPACE; GRADIENT ECHO; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMAGE ANALYSIS; MATHEMATICAL ANALYSIS; MICROVASCULARIZATION; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SIGNAL DETECTION; SPIN ECHO; STATISTICAL SIGNIFICANCE; VEIN BLOOD FLOW; VISUAL CORTEX;

EID: 0038778596     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.10472     Document Type: Article

References (40)

1. Ogawa S, Menon RS, Tank DW, Kim S-G, Merkle H, Ellermann JM, Ugurbil K. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. Biophys J 1993;64:800-812.
2. Boxerman JL, Hamberg LM, Rosen BR, Weisskoff RM. MR contrast due to Intravascular magnetic susceptibility perturbations. Magn Reson Med 1995;34:555-566.
3. Duong TQ, Silva AC, Lee S-P, Kim S-G. Functional MRI of calciumdependent synaptic activity: cross correlation with CBF and BOLD measurements. Magn Reson Med 2000;43:338-392.
4. Haacke E, Lai S, Yablonskiy D, Lin W. In vivo validation of the BOLD mechanism: A review of signal changes in gradient echo functional MRI in the presence of flow. Int J Imag Syst Technol 1995;6:153-163.
5. Ugurbil K, Hu X, Chen W, Zhu XH, Kim S-G, Georgopoulos A. Functional mapping in the human brain using high magnetic fields. Philos Trans R Soc Lond B 1999:354:1195-1213.
6. Bandettini PA, Wong EC, Jesmanowicz A, Hinks RS, Hyde JS. Spinecho gradient-echo EPI of human brain activation using BOLD contrast: a comparative study at 1.5T. NMR Biomed 1994;7:12-20.
7. Lee S-P, Silva AC, Ugurbil K, Kim S-G. Diffusion-weighted spin-echo fMRI at 9.4 T: microvascular/tissue contribution to BOLD signal change. Magn Reson Med 1999;42:919-928.
8. Oja JME, Gillen J, Kauppinen RA, Kraut M, van Zijl PCM. Venous blood effects in spin-echo fMRI of human brain. Magn Reson Med 1999;42:617-626.
9. Ogawa S, Menon RS, Kim S-G, Ugurbil K. On the characteristics of functional magnetic resonance imaging of the brain. Annu Rev Biophys Biomol Struct 1998;27:447-474.
10. Stejskal EO, Tanner JE. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 1965;42:288-292.
11. LeBihan D, Breton E, Lallemand D, Aubin ML, Vitnaud J, Laval-Jeantet M. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 1988;168:497-505.
12. Song AW, Wong EC, Tan SG, Hyde JS. Diffusion-weighted fMRI at 1.5T. Magn Reson Med 1996;35:155-158.
13. Boxerman JL, Bandettini PA, Kwong KK, Baker JR, Davis TL, Rosen BR, Weisskoff RM. The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn Reson Med 1995;34:4-10.
14. Hoogenraad FG, Pouwels PJ, Hofman MB, Reichenbach JR, Sprenger M, Haacke EM. Quantitative differentiation between BOLD models in fMRI. Magn Reson Med 2001;45:233-246.
15. Thulborn KR, Waterton JC, Mattews PM, Radda GK. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochem Biophys Acta 1982;714:265-270.
16. Lee S-P, Silva AC, Kim S-G. Comparison of diffusion-weighted highresolution CBF and spin-echo BOLD fMRI at 9.4 T. Magn Reson Med 2002;47:736-741.
17. Meyer M, Yu O, Eclancher B, Grucker D, Chambron J. NMR relaxation rates and blood oxygenation level. Magn Reson Med 1995;34:234-241.
18. Bryant R, Marill K, Blackmore C, Francis C. Magnetic relaxation of water and water clots. Magn Reson Med 1990;13:133-144.
19. Luz Z, Meiboom S. Nuclear magnetic resonance study of the protolysis of trimethyammonium ion in aqueous solution - order of the reaction with respect to solvent. J Chem Phys 1963;39:366-370.
20. Wright GA, Hu BS, Macovski A. Estimating oxygen saturation of blood in vivo with MR imaging at 1.5 T. J Magn Reson Imag 1991;1:275-283.
21. Barth M, Moser E. Proton NMR relaxation times of human blood samples at 1.5 T and implications for functional MRI. Cell Mol Biol 1997; 43:783-791.
22. Ogawa S, Lee TM, Barrere B. Sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation. Magn Reson Med 1993;29:205-210.
23. Yacoub E, Shmuel A, Pfeuffer J, van de Moortele P-F, Adriany G, Andersen P, Vaughan JT, Merkle H, Ugurbil K, Hu X. Imaging brain function in humans at 7 Tesla. Magn Reson Med 2001;45:588-594.
24. Kim S-G, Rostrup E, Larsson HBW, Ogawa S, Paulson OB. Simultaneous measurements of CBF and CMRO2 changes by fMRI: significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med 1999;41:1152-1161.
25. Phelps M, Grubb RJ, Ter-Pogossian M. Correlation between PaCO2 and regional cerebral blood volume by x-ray fluorescence. J Appl Physiol 1973;35:274-280.
26. 2 measurements on a 1.5 Tesla commercial imager. Radiology 1989;171:273-276.
27. Wansapura JP, Holland SK, Dunn RS, Ball WS. NMR relaxation times in human brain at 3.0 Tesla. J Magn Reson Imag 1999;9:531-538.
28. Jezzard P, Duewell S, Balaban RS. MR relaxation times in human brain - measurement at 4 T. Radiology 1996;199:773-779.
29. Song AW, Wong EC, Jezmanowicz A, Tan SG, Hyde JS. Diffusion weighted fMRI at 1.5T and 3T. In: Proc 3rd Scientific Meeting ISMRM, 1995, Nice, France. p 457.
30. Yacoub E, Duong TQ, van de Moortele PF, Lindquist M, Adriany G, Kim SK, Hu X, Ugurbil K. Spin echo fMRI in humans using high spatial resolutions and high magnetic fields. Magn Reson Med 2003;49:655-664.
31. Lai S, Hopkins AL, Haacke EM, Li D, Wasserman BA, Buckley P, Friedman H, Meltzer H, Hedera, Friedland R. Identification of vascular structures as a major source of signal contrast in high resolution 2D and 3D functional activation imaging of the motor cortex at 1.5T: preliminary results. Magn Reson Med 1993;30:387-392.
32. Duong TQ, Kim D-S, Ugurbil K, Kim S-G. Spatio-temporal dynamics of the BOLD fMRI signals in cat visual cortex: toward mapping columnar structures using the early negative response. Magn Reson Med 2000; 44:231-242.
33. Duong TQ, Kim D-S, Ugurbil K, Kim S-G. Localized blood flow response at sub-millimeter columnar resolution. Proc Natl Acad Sci USA 2001;98:10904-10909.
34. Kennan RP, Zhong J, Gore JC. Intravascular susceptibility contrast mechanisms in tissues. Magn Reson Med 1994;31:9-21.
35. Bartha R, Michaeli S, Merkle H, Adriany G, Andersen P, Chen W, Ugurbil K, Garwood M. In vivo 1H2O T2 measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrast. Magn Reson Med 2002;47:742-750.
36. Menon RS, Hu X, Adriany G, Andersen P, Ogawa S, Ugurbil K. Comparison of SE-EPI, ASE-EPI and conventional EPI applied to functional neuroimaging: the effect of flow crushing gradients on the BOLD signal. Proc Soc Magn Reson 1994;2:622.
37. Neil J, Ackerman J. Detection of pseudodiffusion in rat brain following blood substitution with perfluorocarbon. J Magn Reson 1992;97:194-201.
38. Duong TQ, Kim S-G. In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain. Magn Reson Med 2000;43:392-402.
39. Henkelman RM, Neil JJ, Xiang Q-S. A quantitative interpretation of IVIM measurements of vascular perfusion in the rat brain. Magn Reson Med 1994;32:464-469.
40. Darquié A, Poline J-B, Poupon C, Saint-Jalmes H, LeBihan D. Transient decrease in water diffusion observed in human occipital cortex during visual stimulation. Proc Natl Acad Sci USA 2001;98:9391-9395.