Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: Relevance as a potential biomarker for detecting drug-induced emesis

NeuroImage

Volumn 33, Issue 4, 2006, Pages 1152-1160

  Chin, Chih Liang ^a   Fox, Gerard B ^a   Hradil, Vincent P ^a   Osinski, Mark A ^a   McGaraughty, Steve P ^a   Skoubis, Pamela D ^a   Cox, Bryan F ^a   Luo, Yanping ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ABT 594; Awake rat; Emesis; fMRI; phMRI; rCBV

Indexed keywords

5 (2 AZETIDINYLMETHOXY) 2 CHLOROPYRIDINE; APOMORPHINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA POSTREMA; ARTICLE; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN CORTEX; CORRELATION ANALYSIS; ELECTROENCEPHALOGRAM; HEMODYNAMICS; MALE; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; VOMITING; WAKEFULNESS;

ANIMALS; APOMORPHINE; AREA POSTREMA; AZETIDINES; DOPAMINE AGONISTS; MAGNETIC RESONANCE IMAGING; MALE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SOLITARY NUCLEUS; VOMITING; WAKEFULNESS;

EID: 33750683361     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2006.06.059     Document Type: Article

References (60)

1. Andrews P.L., Naylor R.J., and Joss R.A. Neuropharmacology of emesis and its relevance to anti-emetic therapy. Consensus and controversies. Support. Care Cancer 6 (1998) 197-203
2. Andrews P.L., Kovacs M., and Watson J.W. The anti-emetic action of the neurokinin(1) receptor antagonist CP-99,994 does not require the presence of the area postrema in the dog. Neurosci. Lett. 314 (2001) 102-104
3. Ariumi H., Saito R., Nago S., Hyakusoku M., Takano Y., and Kamiya H. The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis. Neurosci. Lett. 286 (2000) 123-126
4. Aung H.H., Mehendale S.R., Xie J.T., Moss J., and Yuan C.S. Methylnaltrexone prevents morphine-induced kaolin intake in the rat. Life Sci. 74 (2004) 2685-2691
5. Austin V.C., Blamire A.M., Allers K.A., Sharp T., Styles P., Matthews P.M., and Sibson N.R. Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia. NeuroImage 24 (2005) 92-100
6. Bannon A.W., Decker M.W., Holladay M.W., Curzon P., Donnelly-Roberts D., Puttfarcken P.S., Bitner R.S., Diaz A., Dickenson A.H., Porsolt R.D., Williams M., and Arneric S.P. Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science 279 (1998) 77-81
7. Bannon A.W., Decker M.W., Kim D.J., Campbell J.E., and Arneric S.P. ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain. Brain Res. 801 (1998) 158-163
8. Baude A., and Shigemoto R. Cellular and subcellular distribution of substance P receptor immunoreactivity in the dorsal vagal complex of the rat and cat: a light and electron microscope study. J. Comp. Neurol. 402 (1998) 181-196
9. Beleslin D.B., and Krstic S.K. Further studies on nicotine-induced emesis: nicotinic mediation in area postrema. Physiol. Behav. 39 (1987) 681-686
10. Brevard M.E., Duong T.Q., King J.A., and Ferris C.F. Changes in MRI signal intensity during hypercapnic challenge under conscious and anesthetized conditions. Magn. Reson. Imaging 21 (2003) 995-1001
11. Chen Y.C., Galpern W.R., Brownell A.L., Matthews R.T., Bogdanov M., Isacson O., Keltner J.R., Beal M.F., Rosen B.R., and Jenkins B.G. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn. Reson. Med. 38 (1997) 389-398
12. Chin C.L., Skubious P.D., Hradil V., McGaraughty S.P., Fox G.B., and Luo Y. Feasibility of detecting ABT-594-induced brain activity using CBV-based fMRI in awake and anesthetized rats. Proc. Int. Soc. Magn. Res. Medicine, 13th Scientific Meeting, Miami Beach, Florida (2005) 1513
13. Cox R.W. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput. Biomed. Res. 29 (1996) 162-173
14. Decker M.W., Meyer M.D., and Sullivan J.P. The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin. Investig. Drugs 10 (2001) 1819-1830
15. Di Chiara G., and Gessa G.L. Pharmacology and neurochemistry of apomorphine. Adv. Pharmacol. Chemother. 15 (1978) 87-160
16. Dubowitz D.J., Bernheim K.A., Chen D.Y., Bradley Jr. W.G., and Andersen R.A. Enhancing fMRI contrast in awake-behaving primates using intravascular magnetite dextran nanoparticles. NeuroReport 12 (2001) 2335-2340
17. Endo T., Hamaue N., Ihira E., Teramoto Y., Liu Y., Hirafuji M., and Minami M. Effects of granisetron, a 5-HT3 receptor antagonist, on 5-hydroxytryptamine (5-HT) release from the isolated ileum in a delayed-emesis rat model. Res. Commun. Mol. Pathol. Pharmacol. 111 (2002) 55-68
18. Endo T., Minami M., Hirafuji M., Hamaue N., and Parvez S. The ferret: a cytotoxic drug-induced emesis model. Biog. Amines 18 (2004) 419-434
19. Gozzi A., Schwarz A., Reese T., Bertani S., Crestan V., and Bifone A. Region-specific effects of nicotine on brain activity: a pharmacological MRI study in the drug-naive rat. Neuropsychopharmacology 31 8 (2006) 1690-1703
20. Harding R.K., Hugenholtz H., Kucharczyk J., and Lemoine J. Central mechanisms for apomorphine-induced emesis in the dog. Eur. J. Pharmacol. 144 (1987) 61-65
21. Hargreaves R. Imaging substance P receptors (NK1) in the living human brain using positron emission tomography. J. Clin. Psychiatry 63 Suppl. 11 (2002) 18-24
22. Hoffman W.E., Edelman G., Kochs E., Werner C., Segil L., and Albrecht R.F. Cerebral autoregulation in awake versus isoflurane-anesthetized rats. Anesth. Analg. 73 (1991) 753-757
23. Hornby P.J. Central neurocircuitry associated with emesis. Am. J. Med. 111 Suppl. 8A (2001) 106S-112S
24. Hyland N.P., Abrahams T.P., Fuchs K., Burmeister M.A., and Hornby P.J. Organization and neurochemistry of vagal preganglionic neurons innervating the lower esophageal sphincter in ferrets. J. Comp. Neurol. 430 (2001) 222-234
25. Ireland M.D., Lowe A.S., Reavill C., James M.F., Leslie R.A., and Williams S.C. Mapping the effects of the selective dopamine D2/D3 receptor agonist quinelorane using pharmacological magnetic resonance imaging. Neuroscience 133 (2005) 315-326
26. Jovanovic-Micic D., Strbac M., Krstic S.K., Japundzic N., Samardzic R., and Beleslin D.B. Ablation of the area postrema and emesis. Metab. Brain Dis. 4 (1989) 55-60
27. Kesingland A.C., Gentry C.T., Panesar M.S., Bowes M.A., Vernier J.M., Cube R., Walker K., and Urban L. Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain. Pain 86 (2000) 113-118
28. King G.L. Animal models in the study of vomiting. Can. J. Physiol. Pharmacol. 68 (1990) 260-268
29. King J.A., Garelick T.S., Brevard M.E., Chen W., Messenger T.L., Duong T.Q., and Ferris C.F. Procedure for minimizing stress for fMRI studies in conscious rats. J. Neurosci. Methods 148 2 (2006) 154-160
30. Lahti K.M., Ferris C.F., Li F., Sotak C.H., and King J.A. Comparison of evoked cortical activity in conscious and propofol-anesthetized rats using functional MRI. Magn. Reson. Med. 41 (1999) 412-416
31. Leite F.P., Tsao D., Vanduffel W., Fize D., Sasaki Y., Wald L.L., Dale A.M., Kwong K.K., Orban G.A., Rosen B.R., Tootell R.B., and Mandeville J.B. Repeated fMRI using iron oxide contrast agent in awake, behaving macaques at 3 Tesla. NeuroImage 16 (2002) 283-294
32. Leslie R.A., and James M.F. Pharmacological magnetic resonance imaging: a new application for functional MRI. Trends Pharmacol. Sci. 21 (2000) 314-318
33. Liu Y.L., Malik N., Sanger G.J., Friedman M.I., and Andrews P.L. Pica-A model of nausea? Species differences in response to cisplatin. Physiol. Behav. 85 (2005) 271-277
34. Ludwig R., Bodgdanov G., King J., Allard A., and Ferris C.F. A dual RF resonator system for high-field functional magnetic resonance imaging of small animals. J. Neurosci. Methods 132 (2004) 125-135
35. Lynch III J.J., Wade C.L., Mikusa J.P., Decker M.W., and Honore P. ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. Eur. J. Pharmacol. 509 (2005) 43-48
36. Mandeville J.B., Marota J.J., Kosofsky B.E., Keltner J.R., Weissleder R., Rosen B.R., and Weisskoff R.M. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn. Reson. Med. 39 (1998) 615-624
37. Martin C., Martinale J., Redgrave P., and Mayhew J. Functional brain imaging and electrophysiology in the awake rat. Society of Neuroscience 34th Annual Meeting, San Diego, CA (2004)
38. Miller A.D., and Leslie R.A. The area postrema and vomiting. Front. Neuroendocrinol. 15 (1994) 301-320
39. Miller A.D., and Ruggiero D.A. Emetic reflex arc revealed by expression of the immediate-early gene c-fos in the cat. J. Neurosci. 14 (1994) 871-888
40. Miller A.D., Rowley H.A., Roberts T.P., and Kucharczyk J. Human cortical activity during vestibular- and drug-induced nausea detected using MSI. Ann. N. Y. Acad. Sci. 781 (1996) 670-672
41. Mitchell D., Laycock J.D., and Stephens W.F. Motion sickness-induced pica in the rat. Am. J. Clin. Nutr. 30 (1977) 147-150
42. Mueggler T., Baumann D., Rausch M., and Rudin M. Bicuculline-induced brain activation in mice detected by functional magnetic resonance imaging. Magn. Reson. Med. 46 (2001) 292-298
43. Osinski M.A., Seifert T., Shaughnessy T.K., Gintant G.A., and Cox B.F. Emetic liability testing in ferrets. In: Enna S.J., Williams M., Ferkany J.W., Kenakin T., Porsolt R.D., and Sullivan J.P. (Eds). Current Protocols in Pharmacology (2003), John Wiley and Sons, New York 5.31.1-5.31.8
44. Osinski M.A., Uchic M.E., Seifert T., Shaughnessy T.K., Miller L.N., Nakane M., Cox B.F., Brioni J.D., and Moreland R.B. Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol. Biochem. Behav. 81 (2005) 211-219
45. Ozaki A., and Sukamoto T. Improvement of cisplatin-induced emesis and delayed gastric emptying by KB-R6933, a novel 5-HT3 receptor antagonist. Gen. Pharmacol. 33 (1999) 283-288
46. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1998), Academic Press
47. Peeters R.R., Tindemans I., De Schutter E., and Van der Linden A. Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation. Magn. Reson. Imaging 19 (2001) 821-826
48. Rinaman L., Card J.P., Schwaber J.S., and Miselis R.R. Ultrastructural demonstration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat. J. Neurosci. 9 (1989) 1985-1996
49. Schwarz A., Gozzi A., Reese T., Bertani S., Crestan V., Hagan J., Heidbreder C., and Bifone A. Selective dopamine D(3) receptor antagonist SB-277011-A potentiates phMRI response to acute amphetamine challenge in the rat brain. Synapse 54 (2004) 1-10
50. Shulman R.G., Rothman D.L., and Hyder F. Stimulated changes in localized cerebral energy consumption under anesthesia. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3245-3250
51. Skoubis P.D., Hradil V., Chin C.L., Luo Y., Fox G.B., and McGaraughty S. Mapping brain activity following administration of a nicotinic acetylcholine receptor agonist, ABT-594, using functional magnetic resonance imaging in awake rats. Neuroscience 137 (2006) 583-591
52. Takeda N., Hasegawa S., Morita M., and Matsunaga T. Pica in rats is analogous to emesis: an animal model in emesis research. Pharmacol. Biochem. Behav. 45 (1993) 817-821
53. Takeda N., Hasegawa S., Morita M., Horii A., Uno A., Yamatodani A., and Matsunaga T. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find. Exp. Clin. Pharmacol. 17 (1995) 589-590
54. Tombach B., Reimer P., Bremer C., Allkemper T., Engelhardt M., Mahler M., Ebert W., and Heindel W. First-pass and equilibrium-MRA of the aortoiliac region with a superparamagnetic iron oxide blood pool MR contrast agent (SH U 555 C): results of a human pilot study. NMR Biomed. 17 (2004) 500-506
55. Vera G., Chiarlone A., Martin M.I., and Abalo R. Altered feeding behaviour induced by long-term cisplatin in rats. Auton Neurosci. (2006)
56. Wyrwicz A.M., Chen N., Li L., Weiss C., and Disterhoft J.F. fMRI of visual system activation in the conscious rabbit. Magn. Reson. Med. 44 (2000) 474-478
57. Xi Z.X., Wu G., Stein E.A., and Li S.J. GABAergic mechanisms of heroin-induced brain activation assessed with functional MRI. Magn. Reson. Med. 48 (2002) 838-843
58. Yamada Y., Tsukamoto G., Kobashi M., Sasaki A., and Matsumura T. Abdominal vagi mediate c-Fos expression induced by X-ray irradiation in the nucleus tractus solitarii of the rat. Auton Neurosci. 83 (2000) 29-36
59. Yamamoto K., Matsunaga S., Matsui M., Takeda N., and Yamatodani A. Pica in mice as a new model for the study of emesis. Methods Find. Exp. Clin. Pharmacol. 24 (2002) 135-138
60. Zhang Z., Andersen A.H., Avison M.J., Gerhardt G.A., and Gash D.M. Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys. Brain Res. 852 (2000) 290-296