-
1
-
-
84879077265
-
Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
-
Hebert L, Weauve J, Scherr PA, et al. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology. 2013;80:1778–1783.
-
(2013)
Neurology
, vol.80
, pp. 1778-1783
-
-
Hebert, L.1
Weauve, J.2
Scherr, P.A.3
-
2
-
-
84963972074
-
2016 Alzheimer’s disease facts and figures
-
Alzheimer’s Association. 2016 Alzheimer’s disease facts and figures. Alzheimers Dement. 2016;12:459–509.
-
(2016)
Alzheimers Dement
, vol.12
, pp. 459-509
-
-
-
3
-
-
0003472502
-
-
Fifth, Arlington: American Psychiatric Publishing
-
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Fifth ed. Arlington:American Psychiatric Publishing; 2013.
-
(2013)
Diagnostic and statistical manual of mental disorders
-
-
-
4
-
-
84946199430
-
The prevalence of neuropsychiatric symptoms in alzheimer’s disease: systematic review and meta-analysis
-
Zhao QF, Tan L, Wang HF, et al. The prevalence of neuropsychiatric symptoms in alzheimer’s disease:systematic review and meta-analysis. J Affect Disord. 2016;15:264–271.
-
(2016)
J Affect Disord
, vol.15
, pp. 264-271
-
-
Zhao, Q.F.1
Tan, L.2
Wang, H.F.3
-
5
-
-
84947777381
-
Prevalence of mental health disorders among caregivers of patients with alzheimer’s disease
-
Sallim AB, Sayampanathan AA, Cuttilan A, et al. Prevalence of mental health disorders among caregivers of patients with alzheimer’s disease. J Am Med Dir Assoc. 2015;16:1034–1041.
-
(2015)
J Am Med Dir Assoc
, vol.16
, pp. 1034-1041
-
-
Sallim, A.B.1
Sayampanathan, A.A.2
Cuttilan, A.3
-
7
-
-
46749118971
-
5-HT6 receptor antagonists as novel cognitive enhancing agents for alzheimer’s disease
-
Upton N, Chuang TT, Hunter AJ, et al. 5-HT6 receptor antagonists as novel cognitive enhancing agents for alzheimer’s disease. Neurotherapeutics. 2008;5:458–469.• This article discusses the effect of 5-HT6 receptor antagonists on the serotonergic, GABAergic, noradrenergic, and dopaminergic neurotransmitter pathways.
-
(2008)
Neurotherapeutics
, vol.5
, pp. 458-469
-
-
Upton, N.1
Chuang, T.T.2
Hunter, A.J.3
-
8
-
-
84904501407
-
Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of alzheimer’s disease: a systematic review and meta-analysis
-
Tan CC, Yu JT, Wang HF, et al. Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of alzheimer’s disease:a systematic review and meta-analysis. J Alzheimers Dis. 2014;41:615–631.
-
(2014)
J Alzheimers Dis
, vol.41
, pp. 615-631
-
-
Tan, C.C.1
Yu, J.T.2
Wang, H.F.3
-
9
-
-
37649026816
-
Donepezil for dementia due to alzheimer’s disease
-
Birks J, Harvey RJ. Donepezil for dementia due to alzheimer’s disease. Cochrane Database Syst Rev. 2006;Issue 1. Art. No.CD001190.
-
(2006)
Cochrane Database Syst Rev
, vol.Issue 1. Art. No.CD001190
-
-
Birks, J.1
Harvey, R.J.2
-
10
-
-
41049111771
-
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline
-
Raina P, Santaguida P, Ismaila A, et al. Effectiveness of cholinesterase inhibitors and memantine for treating dementia:evidence review for a clinical practice guideline. Ann Intern Med. 2008;148:379–397.
-
(2008)
Ann Intern Med
, vol.148
, pp. 379-397
-
-
Raina, P.1
Santaguida, P.2
Ismaila, A.3
-
11
-
-
3042567016
-
Long-term donepezil treatment in 565 patients with alzheimer’s disease (AD2000): randomised double-blind trial
-
Courtney C, Farrell D, Gray R, et al. Long-term donepezil treatment in 565 patients with alzheimer’s disease (AD2000):randomised double-blind trial. Lancet. 2004;363:2105–2115.
-
(2004)
Lancet
, vol.363
, pp. 2105-2115
-
-
Courtney, C.1
Farrell, D.2
Gray, R.3
-
12
-
-
42749100518
-
Cholinesterase inhibitors for alzheimer’s disease
-
Birks JS. Cholinesterase inhibitors for alzheimer’s disease. Cochrane Database Syst Rev. 2006;Issue 1. Art. No.CD005593.
-
(2006)
Cochrane Database Syst Rev
-
-
Birks, J.S.1
-
13
-
-
84876891556
-
Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe alzheimer’s disease
-
Gauthier S, Molinuevo JL. Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe alzheimer’s disease. Alzheimers Dement. 2013;9:326–331.
-
(2013)
Alzheimers Dement
, vol.9
, pp. 326-331
-
-
Gauthier, S.1
Molinuevo, J.L.2
-
14
-
-
84962911807
-
The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus
-
Herrik KF, Mørk A, Richard N, et al. The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus. Neuropharmacology. 2016;107:351–363.•• This article outlines the rat studies that have demonstrated the effectiveness of 5-HT6 antagonists as additive therapy to donepezil. Idalopirdine was shown to enhance the effects of donepezil on acetylcholine levels.
-
(2016)
Neuropharmacology
, vol.107
, pp. 351-363
-
-
Herrik, K.F.1
Mørk, A.2
Richard, N.3
-
15
-
-
84988934530
-
The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture
-
Amat-Foraster M, Leiser SC, Herrik KF, et al. The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture. Neuropharmacology. 2016;113(Pt A):45–59.•• This article outlines the rat studies that have demonstrated the effectiveness of 5-HT6 antagonists as additive therapy to donepezil. Idalopirdine was shown to enhance the procognitive effects of donepezil, specifically on gamma oscillations.
-
(2016)
Neuropharmacology
, vol.113
, pp. 45-59
-
-
Amat-Foraster, M.1
Leiser, S.C.2
Herrik, K.F.3
-
17
-
-
64049098761
-
Neuropathology and cognitive impairment in alzheimer’s disease: a complex but coherent relationship
-
Nelson PT, Braak H, Markesbery WR. Neuropathology and cognitive impairment in alzheimer’s disease:a complex but coherent relationship. J Neuropathol Exp Neurol. 2009;68:1–14.
-
(2009)
J Neuropathol Exp Neurol
, vol.68
, pp. 1-14
-
-
Nelson, P.T.1
Braak, H.2
Markesbery, W.R.3
-
18
-
-
0025863618
-
Neuropathological stageing of alzheimer-related changes
-
Braak H, Braak E. Neuropathological stageing of alzheimer-related changes. Acta Neuropathol. 1991;82:239–259.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
19
-
-
0042433479
-
The cholinergic hypothesis of age and alzheimer’s disease-related cognitive deficits: recent challenges and their implications for novel drug development
-
Terry AV, Jr, Buccafusco JJ. The cholinergic hypothesis of age and alzheimer’s disease-related cognitive deficits:recent challenges and their implications for novel drug development. J Pharmacol Exp Ther. 2003;306:821–827.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 821-827
-
-
Terry, A.V.1
Buccafusco, J.J.2
-
20
-
-
0029987475
-
Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats
-
Gérard C, El Mestikawy S, Lebrand C, et al. Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse. 1996;23:164–173.
-
(1996)
Synapse
, vol.23
, pp. 164-173
-
-
Gérard, C.1
El Mestikawy, S.2
Lebrand, C.3
-
21
-
-
0028896011
-
Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry
-
Ward RP, Hamblin MW, Lachowicz JE, et al. Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry. Neuroscience. 1995;64:1105–1111.
-
(1995)
Neuroscience
, vol.64
, pp. 1105-1111
-
-
Ward, R.P.1
Hamblin, M.W.2
Lachowicz, J.E.3
-
22
-
-
0027481384
-
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
-
Monsma FJ, Jr, Shen Y, Ward RP, et al. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993;43:320–327.
-
(1993)
Mol Pharmacol
, vol.43
, pp. 320-327
-
-
Monsma, F.J.1
Shen, Y.2
Ward, R.P.3
-
23
-
-
0033389723
-
Very early decline in recognition memory for odors in Alzheimer’s disease
-
Murphy C, Nordin S, Jinich S. Very early decline in recognition memory for odors in Alzheimer’s disease. Aging Neuropsychol Cogn. 1999;6:229–240.
-
(1999)
Aging Neuropsychol Cogn
, vol.6
, pp. 229-240
-
-
Murphy, C.1
Nordin, S.2
Jinich, S.3
-
24
-
-
84947794935
-
The ins and outs of the striatum: role in drug addiction
-
Yager LM, Garcia AF, Wunsch AM, et al. The ins and outs of the striatum:role in drug addiction. Neuroscience. 2015;301:529–541.
-
(2015)
Neuroscience
, vol.301
, pp. 529-541
-
-
Yager, L.M.1
Garcia, A.F.2
Wunsch, A.M.3
-
25
-
-
0034742606
-
A role for 5-HT6 receptors in retention of spatial learning in the Morris water maze
-
Woolley ML, Bentley JC, Sleight AJ, et al. A role for 5-HT6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology. 2001;41:210–219.
-
(2001)
Neuropharmacology
, vol.41
, pp. 210-219
-
-
Woolley, M.L.1
Bentley, J.C.2
Sleight, A.J.3
-
26
-
-
0032907531
-
Investigation of stretching behaviour induced by selective 5-HT6 receptor antagonist, Ro 04-6790, in rats
-
Bentley JC, Bourson A, Boess FG, et al. Investigation of stretching behaviour induced by selective 5-HT6 receptor antagonist, Ro 04-6790, in rats. Br J Pharmacol. 1999;126:1537–1542.
-
(1999)
Br J Pharmacol
, vol.126
, pp. 1537-1542
-
-
Bentley, J.C.1
Bourson, A.2
Boess, F.G.3
-
27
-
-
0032910197
-
The cholinergic hypothesis of alzheimer’s disease: a review of progress
-
Francis PT, Palmer AM, Snape M, et al. The cholinergic hypothesis of alzheimer’s disease:a review of progress. J Neurol Neurosurg Psychiatry. 1999;66:137–147.
-
(1999)
J Neurol Neurosurg Psychiatry
, vol.66
, pp. 137-147
-
-
Francis, P.T.1
Palmer, A.M.2
Snape, M.3
-
28
-
-
0033018477
-
Acetylcholine in mind: a neurotransmitter correlate of consciousness?
-
Perry E, Walker M, Grace J, et al. Acetylcholine in mind:a neurotransmitter correlate of consciousness? Trends Neurosci. 1999;22:273–280.
-
(1999)
Trends Neurosci
, vol.22
, pp. 273-280
-
-
Perry, E.1
Walker, M.2
Grace, J.3
-
29
-
-
52949099850
-
Effects of 5-HT6 receptor antagonist and cholinesterase inhibition on models of cognitive impairment in the rat
-
Marcos B, Chuang TT, Gil-Bea FJ, et al. Effects of 5-HT6 receptor antagonist and cholinesterase inhibition on models of cognitive impairment in the rat. Br J Pharmacol. 2008;155:434–440.
-
(2008)
Br J Pharmacol
, vol.155
, pp. 434-440
-
-
Marcos, B.1
Chuang, T.T.2
Gil-Bea, F.J.3
-
30
-
-
84865425244
-
5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutaminergic mechanisms
-
Woods S, Clarke NN, Layfield R, et al. 5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutaminergic mechanisms. Br J Pharmacol. 2012;167:436–449.
-
(2012)
Br J Pharmacol
, vol.167
, pp. 436-449
-
-
Woods, S.1
Clarke, N.N.2
Layfield, R.3
-
31
-
-
0034098959
-
In vivo effects of the 5-HT(6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate
-
Dawson LA, Nguyen HQ, Li P. In vivo effects of the 5-HT(6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate. Br J Pharmacol. 2000;130:23–26.
-
(2000)
Br J Pharmacol
, vol.130
, pp. 23-26
-
-
Dawson, L.A.1
Nguyen, H.Q.2
Li, P.3
-
32
-
-
0034782825
-
The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
-
Dawson LA, Nguyen HQ, Li P. The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology. 2001;25:662–668.
-
(2001)
Neuropsychopharmacology
, vol.25
, pp. 662-668
-
-
Dawson, L.A.1
Nguyen, H.Q.2
Li, P.3
-
33
-
-
0027269660
-
Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in alzheimer’s disease: investigative and therapeutic perspectives
-
Francis PT, Sims NR, Procter AW, et al. Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in alzheimer’s disease:investigative and therapeutic perspectives. J Neurochem. 1993;60:1589–1604.
-
(1993)
J Neurochem
, vol.60
, pp. 1589-1604
-
-
Francis, P.T.1
Sims, N.R.2
Procter, A.W.3
-
34
-
-
0030483709
-
Neurochemical studies of Alzheimer’s disease
-
Palmer AM. Neurochemical studies of Alzheimer’s disease. Neurodegeneration. 1996;5:381–391.
-
(1996)
Neurodegeneration
, vol.5
, pp. 381-391
-
-
Palmer, A.M.1
-
36
-
-
42049114860
-
Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466
-
Schechter LE, Lin Q, Smith DL, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists:WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008;33:1323–1335.
-
(2008)
Neuropsychopharmacology
, vol.33
, pp. 1323-1335
-
-
Schechter, L.E.1
Lin, Q.2
Smith, D.L.3
-
37
-
-
0030614562
-
Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system
-
Gérard C, Martres MP, Lefèvre K, et al. Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system. Brain Res. 1997;746:207–219.
-
(1997)
Brain Res
, vol.746
, pp. 207-219
-
-
Gérard, C.1
Martres, M.P.2
Lefèvre, K.3
-
38
-
-
84920834831
-
Charting a path toward combination therapy for alzheimer’s disease
-
Stephenson D, Perry D, Bens C, et al. Charting a path toward combination therapy for alzheimer’s disease. Expert Rev Neurother. 2015;15:107–113.
-
(2015)
Expert Rev Neurother
, vol.15
, pp. 107-113
-
-
Stephenson, D.1
Perry, D.2
Bens, C.3
-
39
-
-
85014715192
-
-
, NLM identifier: NCT02006654, December
-
Lundbeck H, A/S. Randomised, double-blind, parallel-group, placebo-controlled study of Lu AE58054 in patients with mild to moderate Alzheimer’s disease treated with an acetylcholinesterate inhibitor. Available at:https://clinicaltrials.gov/ct2/show/NCT02006654. NLM identifier:NCT02006654. [Last accessed 1December 2016]
-
A/S. Randomised, double-blind, parallel-group, placebo-controlled study of Lu AE58054 in patients with mild to moderate Alzheimer’s disease treated with an acetylcholinesterate inhibitor
-
-
Lundbeck, H.1
-
40
-
-
85014598753
-
-
, NLM identifier: NCT01955161, Last accessed, December
-
Lundbeck H, A/S. Randomised, double-blind, parallel-group, placebo-controlled, fixed-dose study of Lu AE58054 in patients with mild-moderate Alzheimer’s disease treated with donepezil. Available at:https://clinicaltrials.gov/ct2/show/NCT01955161. NLM identifier:NCT01955161. [Last accessed 1 December 2016]
-
(2016)
A/S. Randomised, double-blind, parallel-group, placebo-controlled, fixed-dose study of Lu AE58054 in patients with mild-moderate Alzheimer’s disease treated with donepezil
-
-
Lundbeck, H.1
-
41
-
-
85014646064
-
Lundbeck provides update on Phase 3 Study for Alzheimer’s treatment
-
, December
-
Lundbeck provides update on Phase 3 Study for Alzheimer’s treatment. Drug Discov Dev. 2016; Available at http://www.dddmag.com/news/2016/09/lundbeck-provides-update-phase-3-study-alzheimers-treatment [Last accessed 1December 2016].
-
(2016)
Drug Discov Dev
-
-
-
42
-
-
85014706902
-
-
, NLM identifier: 02585934, Last accessed, December
-
Axovant sciences Ltd. A phase 3, double-blind, randomized study of RVT-101 versus plaecbo when added to existing stable donepezil treatment in subjects with mild to moderate Alzheimer’s disease. Available at. https://clinicaltrials.gov/ct2/show/NCT02585934. NLM identifier:02585934. [Last accessed 1 December 2016]
-
(2016)
-
-
-
43
-
-
85014659582
-
Suven Inc, Suven Life Sciences. A phase 2a multicenter, randomized, double-Blind, parallel group, 26-week, placebo-controlled study of SUVN-502 in subjects with moderate Alzheimer’s disease currently treated with onepezil hydrochloride and memantine hydrochloride
-
[Internet], Cited, November, NLM identifier: NCT02580305
-
Suven Inc, Suven Life Sciences. A phase 2a multicenter, randomized, double-Blind, parallel group, 26-week, placebo-controlled study of SUVN-502 in subjects with moderate Alzheimer’s disease currently treated with onepezil hydrochloride and memantine hydrochloride. ClinicalTrials.gov. [Internet]. Cited November 2016. Available at:https://clinicaltrials.gov/ct2/show/NCT02580305 NLM identifier:NCT02580305.
-
(2016)
ClinicalTrials.gov
-
-
-
45
-
-
84947029366
-
Idalopirdine-a small molecule antagonist of 5-HT6 with therapeutic potential against obesity
-
Dudek M, Marcinkowska M, Bucki A, et al. Idalopirdine-a small molecule antagonist of 5-HT6 with therapeutic potential against obesity. Metab Brain Dis. 2015;30:1487–1494.
-
(2015)
Metab Brain Dis
, vol.30
, pp. 1487-1494
-
-
Dudek, M.1
Marcinkowska, M.2
Bucki, A.3
|