Probing the evolutionary history of human bitter taste receptor pseudogenes by restoring their function

Molecular Biology and Evolution

Volumn 34, Issue 7, 2017, Pages 1587-1595

  Risso, Davide ^a,b,d   Behrens, Maik ^c   Sainz, Eduardo ^a   Meyerhof, Wolfgang ^c   Drayna, Dennis ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Adaptive evolution; Bitter taste; Pseudogenes; Synthetic biology; TAS2Rs

Indexed keywords

ARTICLE; BITTER TASTE; CELL MEMBRANE; CONTROLLED STUDY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENETIC VARIATION; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; NONHUMAN; OPEN READING FRAME; PROTEIN SECONDARY STRUCTURE; PSEUDOGENE; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE BUD; ANIMAL; EVOLUTION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; PAN TROGLODYTES; PHYLOGENY; SPECIES DIFFERENCE; SYNTHETIC BIOLOGY; TASTE;

G PROTEIN COUPLED RECEPTOR; LIGAND;

ANIMALS; BIOLOGICAL EVOLUTION; EVOLUTION, MOLECULAR; HUMANS; LIGANDS; PAN TROGLODYTES; PHYLOGENY; PSEUDOGENES; RECEPTORS, G-PROTEIN-COUPLED; SPECIES SPECIFICITY; SYNTHETIC BIOLOGY; TASTE; TASTE BUDS;

EID: 85020222223     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msx097     Document Type: Article

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