메뉴 건너뛰기




Volumn 14, Issue 1, 2017, Pages

HIV drug resistance against strand transfer integrase inhibitors

Author keywords

Bictegravir; Cabotegravir; Clinic; Dolutegravir; Elvitegravir; HIV; INSTIs; Raltegravir; Resistance; Selections

Indexed keywords

BICTEGRAVIR; CABOTEGRAVIR; DOLUTEGRAVIR; ELVITEGRAVIR; INTEGRASE INHIBITOR; INTEGRASE STRAND TRANSFER INHIBITOR; RALTEGRAVIR; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; INTEGRASE;

EID: 85020207920     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/s12977-017-0360-7     Document Type: Review
Times cited : (150)

References (90)
  • 2
    • 80051829496 scopus 로고    scopus 로고
    • Development of antiretroviral drug resistance
    • Wainberg MA, Zaharatos GJ, Brenner BG. Development of antiretroviral drug resistance. N Engl J Med. 2011;365(7):637-46.
    • (2011) N Engl J Med , vol.365 , Issue.7 , pp. 637-646
    • Wainberg, M.A.1    Zaharatos, G.J.2    Brenner, B.G.3
  • 3
    • 84868612381 scopus 로고    scopus 로고
    • The origin of genetic diversity in HIV-1
    • Smyth RP, Davenport MP, Mak J. The origin of genetic diversity in HIV-1. Virus Res. 2012;169(2):415-29.
    • (2012) Virus Res , vol.169 , Issue.2 , pp. 415-429
    • Smyth, R.P.1    Davenport, M.P.2    Mak, J.3
  • 4
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder BA, Kemp SD. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science. 1989;246(4934):1155-8.
    • (1989) Science , vol.246 , Issue.4934 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 5
    • 78149434355 scopus 로고    scopus 로고
    • The mechanism of retroviral integration from X-ray structures of its key intermediates
    • Maertens GN, Hare S, Cherepanov P. The mechanism of retroviral integration from X-ray structures of its key intermediates. Nature. 2010;468(7321):326-9.
    • (2010) Nature , vol.468 , Issue.7321 , pp. 326-329
    • Maertens, G.N.1    Hare, S.2    Cherepanov, P.3
  • 6
  • 7
    • 84992371644 scopus 로고    scopus 로고
    • Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: structural and thermodynamic modeling studies
    • Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, et al. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: structural and thermodynamic modeling studies. Protein Sci. 2016;25(11):1911-7.
    • (2016) Protein Sci , vol.25 , Issue.11 , pp. 1911-1917
    • Deng, N.1    Hoyte, A.2    Mansour, Y.E.3    Mohamed, M.S.4    Fuchs, J.R.5    Engelman, A.N.6
  • 8
    • 0034622521 scopus 로고    scopus 로고
    • Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy
    • Deprez E, Tauc P, Leh H, Mouscadet JF, Auclair C, Brochon JC. Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy. Biochemistry. 2000;39(31):9275-84.
    • (2000) Biochemistry , vol.39 , Issue.31 , pp. 9275-9284
    • Deprez, E.1    Tauc, P.2    Leh, H.3    Mouscadet, J.F.4    Auclair, C.5    Brochon, J.C.6
  • 9
    • 33747330377 scopus 로고    scopus 로고
    • Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
    • Guiot E, Carayon K, Delelis O, Simon F, Tauc P, Zubin E, et al. Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity. J Biol Chem. 2006;281(32):22707-19.
    • (2006) J Biol Chem , vol.281 , Issue.32 , pp. 22707-22719
    • Guiot, E.1    Carayon, K.2    Delelis, O.3    Simon, F.4    Tauc, P.5    Zubin, E.6
  • 10
    • 85009289750 scopus 로고    scopus 로고
    • Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome
    • Passos DO, Li M, Yang R, Rebensburg SV, Ghirlando R, Jeon Y, et al. Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome. Science. 2017;355(6320):89-92.
    • (2017) Science , vol.355 , Issue.6320 , pp. 89-92
    • Passos, D.O.1    Li, M.2    Yang, R.3    Rebensburg, S.V.4    Ghirlando, R.5    Jeon, Y.6
  • 13
    • 84873077102 scopus 로고    scopus 로고
    • HIV drug resistance and the advent of integrase inhibitors
    • Quashie PK, Mesplede T, Wainberg MA. HIV drug resistance and the advent of integrase inhibitors. Curr Infect Dis Rep. 2013;15(1):85-100.
    • (2013) Curr Infect Dis Rep. , vol.15 , Issue.1 , pp. 85-100
    • Quashie, P.K.1    Mesplede, T.2    Wainberg, M.A.3
  • 14
    • 84996488595 scopus 로고    scopus 로고
    • Antiviral activity of bictegravir (GS-9883), a novel potent HIV-1 integrase strand transfer inhibitor with an improved resistance profile
    • Tsiang M, Jones GS, Goldsmith J, Mulato A, Hansen D, Kan E, et al. Antiviral activity of bictegravir (GS-9883), a novel potent HIV-1 integrase strand transfer inhibitor with an improved resistance profile. Antimicrob Agents Chemother. 2016;60(12):7086-97.
    • (2016) Antimicrob Agents Chemother , vol.60 , Issue.12 , pp. 7086-7097
    • Tsiang, M.1    Jones, G.S.2    Goldsmith, J.3    Mulato, A.4    Hansen, D.5    Kan, E.6
  • 15
    • 84942191100 scopus 로고    scopus 로고
    • Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised, phase 2b, dose-ranging trial
    • Margolis DA, Brinson CC, Smith GH, de Vente J, Hagins DP, Eron JJ, et al. Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised, phase 2b, dose-ranging trial. Lancet Infect Dis. 2015;15(10):1145-55.
    • (2015) Lancet Infect Dis. , vol.15 , Issue.10 , pp. 1145-1155
    • Margolis, D.A.1    Brinson, C.C.2    Smith, G.H.3    Vente, J.4    Hagins, D.P.5    Eron, J.J.6
  • 17
    • 84885948765 scopus 로고    scopus 로고
    • Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial
    • Raffi F, Jaeger H, Quiros-Roldan E, Albrecht H, Belonosova E, Gatell JM, et al. Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial. Lancet Infect Dis. 2013;13(11):927-35.
    • (2013) Lancet Infect Dis. , vol.13 , Issue.11 , pp. 927-935
    • Raffi, F.1    Jaeger, H.2    Quiros-Roldan, E.3    Albrecht, H.4    Belonosova, E.5    Gatell, J.M.6
  • 19
    • 85012877727 scopus 로고    scopus 로고
    • Bictegravir versus dolutegravir, each with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection: a randomised, double-blind, phase 2 trial
    • Sax PE, DeJesus E, Crofoot G, Ward D, Benson P, Dretler R, et al. Bictegravir versus dolutegravir, each with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection: a randomised, double-blind, phase 2 trial. Lancet HIV. 2017;4(4):e154-60.
    • (2017) Lancet HIV , vol.4 , Issue.4 , pp. e154-e160
    • Sax, P.E.1    DeJesus, E.2    Crofoot, G.3    Ward, D.4    Benson, P.5    Dretler, R.6
  • 20
    • 84882912698 scopus 로고    scopus 로고
    • Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study
    • Cahn P, Pozniak AL, Mingrone H, Shuldyakov A, Brites C, Andrade-Villanueva JF, et al. Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study. Lancet. 2013;382(9893):700-8.
    • (2013) Lancet , vol.382 , Issue.9893 , pp. 700-708
    • Cahn, P.1    Pozniak, A.L.2    Mingrone, H.3    Shuldyakov, A.4    Brites, C.5    Andrade-Villanueva, J.F.6
  • 21
    • 33748879209 scopus 로고    scopus 로고
    • Rationale and uses of a public HIV drug-resistance database
    • Shafer RW. Rationale and uses of a public HIV drug-resistance database. J Infect Dis. 2006;194(Suppl 1):S51-8.
    • (2006) J Infect Dis , vol.194 , pp. S51-S58
    • Shafer, R.W.1
  • 22
    • 62149093020 scopus 로고    scopus 로고
    • The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
    • Delelis O, Malet I, Na L, Tchertanov L, Calvez V, Marcelin AG, et al. The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation. Nucleic Acids Res. 2009;37(4):1193-201.
    • (2009) Nucleic Acids Res , vol.37 , Issue.4 , pp. 1193-1201
    • Delelis, O.1    Malet, I.2    Na, L.3    Tchertanov, L.4    Calvez, V.5    Marcelin, A.G.6
  • 24
    • 3242769788 scopus 로고    scopus 로고
    • Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
    • Hazuda DJ, Young SD, Guare JP, Anthony NJ, Gomez RP, Wai JS, et al. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science. 2004;305(5683):528-32.
    • (2004) Science , vol.305 , Issue.5683 , pp. 528-532
    • Hazuda, D.J.1    Young, S.D.2    Guare, J.P.3    Anthony, N.J.4    Gomez, R.P.5    Wai, J.S.6
  • 25
    • 77951672581 scopus 로고    scopus 로고
    • FDA approves raltegravir for HIV-1 treatment-naive patients
    • FDA notifications. FDA approves raltegravir for HIV-1 treatment-naive patients. AIDS Alert. 2009;24(9):106-7.
    • (2009) AIDS Alert. , vol.24 , Issue.9 , pp. 106-107
  • 26
    • 84880580320 scopus 로고    scopus 로고
    • HIV integrase inhibitors: 20-year landmark and challenges
    • Metifiot M, Marchand C, Pommier Y. HIV integrase inhibitors: 20-year landmark and challenges. Adv Pharmacol. 2013;67:75-105.
    • (2013) Adv Pharmacol , vol.67 , pp. 75-105
    • Metifiot, M.1    Marchand, C.2    Pommier, Y.3
  • 27
    • 42049119625 scopus 로고    scopus 로고
    • Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
    • Malet I, Delelis O, Valantin MA, Montes B, Soulie C, Wirden M, et al. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemother. 2008;52(4):1351-8.
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.4 , pp. 1351-1358
    • Malet, I.1    Delelis, O.2    Valantin, M.A.3    Montes, B.4    Soulie, C.5    Wirden, M.6
  • 28
    • 79954626457 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitor resistance and its clinical implications
    • Blanco JL, Varghese V, Rhee SY, Gatell JM, Shafer RW. HIV-1 integrase inhibitor resistance and its clinical implications. J Infect Dis. 2011;203(9):1204-14.
    • (2011) J Infect Dis , vol.203 , Issue.9 , pp. 1204-1214
    • Blanco, J.L.1    Varghese, V.2    Rhee, S.Y.3    Gatell, J.M.4    Shafer, R.W.5
  • 30
    • 34447263572 scopus 로고    scopus 로고
    • Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
    • Lataillade M, Chiarella J, Kozal MJ. Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance. Antivir Ther. 2007;12(4):563-70.
    • (2007) Antivir Ther. , vol.12 , Issue.4 , pp. 563-570
    • Lataillade, M.1    Chiarella, J.2    Kozal, M.J.3
  • 31
    • 84904559099 scopus 로고    scopus 로고
    • New raltegravir resistance pathways induce broad cross-resistance to all currently used integrase inhibitors
    • Malet I, Gimferrer Arriaga L, Artese A, Costa G, Parrotta L, Alcaro S, et al. New raltegravir resistance pathways induce broad cross-resistance to all currently used integrase inhibitors. J Antimicrob Chemother. 2014;69(8):2118-22.
    • (2014) J Antimicrob Chemother , vol.69 , Issue.8 , pp. 2118-2122
    • Malet, I.1    Gimferrer Arriaga, L.2    Artese, A.3    Costa, G.4    Parrotta, L.5    Alcaro, S.6
  • 33
    • 84863393356 scopus 로고    scopus 로고
    • Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir
    • Quashie PK, Mesplede T, Han YS, Oliveira M, Singhroy DN, Fujiwara T, et al. Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol. 2012;86(5):2696-705.
    • (2012) J Virol , vol.86 , Issue.5 , pp. 2696-2705
    • Quashie, P.K.1    Mesplede, T.2    Han, Y.S.3    Oliveira, M.4    Singhroy, D.N.5    Fujiwara, T.6
  • 34
    • 84978961912 scopus 로고    scopus 로고
    • Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors
    • Brenner BG, Thomas R, Blanco JL, Ibanescu RI, Oliveira M, Mesplede T, et al. Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors. J Antimicrob Chemother. 2016;71(7):1948-53.
    • (2016) J Antimicrob Chemother , vol.71 , Issue.7 , pp. 1948-1953
    • Brenner, B.G.1    Thomas, R.2    Blanco, J.L.3    Ibanescu, R.I.4    Oliveira, M.5    Mesplede, T.6
  • 35
    • 84998630510 scopus 로고    scopus 로고
    • Resistance post week 48 in ART-experienced, integrase inhibitor-naïve subjects with dolutegravir (DTG) vs. raltegravir (RAL) in SAILING (ING111762)
    • June 3-5, 2015. Barcelona;
    • Underwood M, Deanda F, Dorey D, Hightower GK, Wang R, Griffith S, et al. Resistance post week 48 in ART-experienced, integrase inhibitor-naïve subjects with dolutegravir (DTG) vs. raltegravir (RAL) in SAILING (ING111762). In: Proceedings of the 13th European HIV and hepatitis workshop; June 3-5, 2015. Barcelona; 2015.
    • (2015) In: Proceedings of the 13th European HIV and hepatitis workshop
    • Underwood, M.1    Deanda, F.2    Dorey, D.3    Hightower, G.K.4    Wang, R.5    Griffith, S.6
  • 36
    • 37849002059 scopus 로고    scopus 로고
    • Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
    • Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol. 2008;82(2):764-74.
    • (2008) J Virol , vol.82 , Issue.2 , pp. 764-774
    • Shimura, K.1    Kodama, E.2    Sakagami, Y.3    Matsuzaki, Y.4    Watanabe, W.5    Yamataka, K.6
  • 37
    • 84999028775 scopus 로고    scopus 로고
    • Differences among HIV-1 subtypes in drug resistance against integrase inhibitors
    • Han YS, Mesplede T, Wainberg MA. Differences among HIV-1 subtypes in drug resistance against integrase inhibitors. Infect Genet Evol. 2016;46:286-91.
    • (2016) Infect Genet Evol. , vol.46 , pp. 286-291
    • Han, Y.S.1    Mesplede, T.2    Wainberg, M.A.3
  • 39
    • 84867400091 scopus 로고    scopus 로고
    • The development of novel HIV integrase inhibitors and the problem of drug resistance
    • Wainberg MA, Mesplede T, Quashie PK. The development of novel HIV integrase inhibitors and the problem of drug resistance. Curr Opin Virol. 2012;2(5):656-62.
    • (2012) Curr Opin Virol. , vol.2 , Issue.5 , pp. 656-662
    • Wainberg, M.A.1    Mesplede, T.2    Quashie, P.K.3
  • 40
    • 53249087908 scopus 로고    scopus 로고
    • Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants
    • Kobayashi M, Nakahara K, Seki T, Miki S, Kawauchi S, Suyama A, et al. Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antivir Res. 2008;80(2):213-22.
    • (2008) Antivir Res. , vol.80 , Issue.2 , pp. 213-222
    • Kobayashi, M.1    Nakahara, K.2    Seki, T.3    Miki, S.4    Kawauchi, S.5    Suyama, A.6
  • 41
    • 79959574846 scopus 로고    scopus 로고
    • Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor
    • Goethals O, Van Ginderen M, Vos A, Cummings MD, Van Der Borght K, Van Wesenbeeck L, et al. Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor. Antivir Res. 2011;91(2):167-76.
    • (2011) Antivir Res. , vol.91 , Issue.2 , pp. 167-176
    • Goethals, O.1    Ginderen, M.2    Vos, A.3    Cummings, M.D.4    Borght, K.5    Wesenbeeck, L.6
  • 42
    • 78650238190 scopus 로고    scopus 로고
    • Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure
    • Codoner FM, Pou C, Thielen A, Garcia F, Delgado R, Dalmau D, et al. Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure. Antivir Res. 2010;88(3):281-6.
    • (2010) Antivir Res. , vol.88 , Issue.3 , pp. 281-286
    • Codoner, F.M.1    Pou, C.2    Thielen, A.3    Garcia, F.4    Delgado, R.5    Dalmau, D.6
  • 43
    • 84873633830 scopus 로고    scopus 로고
    • Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study
    • Eron JJ, Clotet B, Durant J, Katlama C, Kumar P, Lazzarin A, et al. Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study. J Infect Dis. 2013;207(5):740-8.
    • (2013) J Infect Dis , vol.207 , Issue.5 , pp. 740-748
    • Eron, J.J.1    Clotet, B.2    Durant, J.3    Katlama, C.4    Kumar, P.5    Lazzarin, A.6
  • 44
    • 84976514928 scopus 로고    scopus 로고
    • Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility
    • Varghese V, Pinsky BA, Smith DS, Klein D, Shafer RW. Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility. AIDS Res Hum Retroviruses. 2016;32(7):702-4.
    • (2016) AIDS Res Hum Retroviruses , vol.32 , Issue.7 , pp. 702-704
    • Varghese, V.1    Pinsky, B.A.2    Smith, D.S.3    Klein, D.4    Shafer, R.W.5
  • 45
    • 84943778107 scopus 로고    scopus 로고
    • Combination of two pathways involved in raltegravir resistance confers dolutegravir resistance
    • Malet I, Thierry E, Wirden M, Lebourgeois S, Subra F, Katlama C, et al. Combination of two pathways involved in raltegravir resistance confers dolutegravir resistance. J Antimicrob Chemother. 2015;70(10):2870-80.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.10 , pp. 2870-2880
    • Malet, I.1    Thierry, E.2    Wirden, M.3    Lebourgeois, S.4    Subra, F.5    Katlama, C.6
  • 46
    • 73849095055 scopus 로고    scopus 로고
    • Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo
    • Delelis O, Thierry S, Subra F, Simon F, Malet I, Alloui C, et al. Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo. Antimicrob Agents Chemother. 2010;54(1):491-501.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.1 , pp. 491-501
    • Delelis, O.1    Thierry, S.2    Subra, F.3    Simon, F.4    Malet, I.5    Alloui, C.6
  • 47
    • 73949084442 scopus 로고    scopus 로고
    • Raltegravir has no residual antiviral activity in vivo against HIV-1 with resistance-associated mutations to this drug
    • Wirden M, Simon A, Schneider L, Tubiana R, Malet I, Ait-Mohand H, et al. Raltegravir has no residual antiviral activity in vivo against HIV-1 with resistance-associated mutations to this drug. J Antimicrob Chemother. 2009;64(5):1087-90.
    • (2009) J Antimicrob Chemother , vol.64 , Issue.5 , pp. 1087-1090
    • Wirden, M.1    Simon, A.2    Schneider, L.3    Tubiana, R.4    Malet, I.5    Ait-Mohand, H.6
  • 49
    • 55249105017 scopus 로고    scopus 로고
    • Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors
    • Goethals O, Clayton R, Van Ginderen M, Vereycken I, Wagemans E, Geluykens P, et al. Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol. 2008;82(21):10366-74.
    • (2008) J Virol , vol.82 , Issue.21 , pp. 10366-10374
    • Goethals, O.1    Clayton, R.2    Ginderen, M.3    Vereycken, I.4    Wagemans, E.5    Geluykens, P.6
  • 50
    • 78650640149 scopus 로고    scopus 로고
    • Cross-resistance profile determination of two second-generation HIV-1 integrase inhibitors using a panel of recombinant viruses derived from raltegravir-treated clinical isolates
    • Van Wesenbeeck L, Rondelez E, Feyaerts M, Verheyen A, Van der Borght K, Smits V, et al. Cross-resistance profile determination of two second-generation HIV-1 integrase inhibitors using a panel of recombinant viruses derived from raltegravir-treated clinical isolates. Antimicrob Agents Chemother. 2011;55(1):321-5.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.1 , pp. 321-325
    • Wesenbeeck, L.1    Rondelez, E.2    Feyaerts, M.3    Verheyen, A.4    Borght, K.5    Smits, V.6
  • 52
    • 84931292120 scopus 로고    scopus 로고
    • Effects of raltegravir or elvitegravir resistance signature mutations on the barrier to dolutegravir resistance in vitro
    • Seki T, Suyama-Kagitani A, Kawauchi-Miki S, Miki S, Wakasa-Morimoto C, Akihisa E, et al. Effects of raltegravir or elvitegravir resistance signature mutations on the barrier to dolutegravir resistance in vitro. Antimicrob Agents Chemother. 2015;59(5):2596-606.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.5 , pp. 2596-2606
    • Seki, T.1    Suyama-Kagitani, A.2    Kawauchi-Miki, S.3    Miki, S.4    Wakasa-Morimoto, C.5    Akihisa, E.6
  • 53
    • 84882353303 scopus 로고    scopus 로고
    • Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir
    • Huang W, Frantzell A, Fransen S, Petropoulos CJ. Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir. Antimicrob Agents Chemother. 2013;57(9):4105-13.
    • (2013) Antimicrob Agents Chemother , vol.57 , Issue.9 , pp. 4105-4113
    • Huang, W.1    Frantzell, A.2    Fransen, S.3    Petropoulos, C.J.4
  • 54
    • 84928186352 scopus 로고    scopus 로고
    • G118R and F121Y mutations identified in patients failing raltegravir treatment confer dolutegravir resistance
    • Munir S, Thierry E, Malet I, Subra F, Calvez V, Marcelin AG, et al. G118R and F121Y mutations identified in patients failing raltegravir treatment confer dolutegravir resistance. J Antimicrob Chemother. 2015;70(3):739-49.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.3 , pp. 739-749
    • Munir, S.1    Thierry, E.2    Malet, I.3    Subra, F.4    Calvez, V.5    Marcelin, A.G.6
  • 55
    • 84923206490 scopus 로고    scopus 로고
    • Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase
    • Quashie PK, Oliviera M, Veres T, Osman N, Han YS, Hassounah S, et al. Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase. J Virol. 2015;89(6):3163-75.
    • (2015) J Virol , vol.89 , Issue.6 , pp. 3163-3175
    • Quashie, P.K.1    Oliviera, M.2    Veres, T.3    Osman, N.4    Han, Y.S.5    Hassounah, S.6
  • 56
    • 84945897017 scopus 로고    scopus 로고
    • The combination of the R263K and T66I resistance substitutions in HIV-1 integrase is incompatible with high level viral replication and the development of high-level drug resistance
    • Liang J, Mesplede T, Oliveira M, Anstett K, Wainberg MA. The combination of the R263K and T66I resistance substitutions in HIV-1 integrase is incompatible with high level viral replication and the development of high-level drug resistance. J Virol. 2015;85(22):11269-74.
    • (2015) J Virol , vol.85 , Issue.22 , pp. 11269-11274
    • Liang, J.1    Mesplede, T.2    Oliveira, M.3    Anstett, K.4    Wainberg, M.A.5
  • 57
    • 84925424676 scopus 로고    scopus 로고
    • Dolutegravir resistance mutation R263K cannot coexist in combination with many classical integrase inhibitor resistance substitutions
    • Anstett K, Mesplede T, Oliveira M, Cutillas V, Wainberg MA. Dolutegravir resistance mutation R263K cannot coexist in combination with many classical integrase inhibitor resistance substitutions. J Virol. 2015;89(8):4681-4.
    • (2015) J Virol , vol.89 , Issue.8 , pp. 4681-4684
    • Anstett, K.1    Mesplede, T.2    Oliveira, M.3    Cutillas, V.4    Wainberg, M.A.5
  • 58
    • 84942163391 scopus 로고    scopus 로고
    • Dolutegravir-selected HIV-1 containing the N155H and R263K resistance substitutions does not acquire additional compensatory mutations under drug pressure that lead to higher-level resistance and increased replicative capacity
    • Anstett K, Fusco R, Cutillas V, Mesplede T, Wainberg MA. Dolutegravir-selected HIV-1 containing the N155H and R263K resistance substitutions does not acquire additional compensatory mutations under drug pressure that lead to higher-level resistance and increased replicative capacity. J Virol. 2015;89(20):10482-8.
    • (2015) J Virol , vol.89 , Issue.20 , pp. 10482-10488
    • Anstett, K.1    Fusco, R.2    Cutillas, V.3    Mesplede, T.4    Wainberg, M.A.5
  • 59
    • 84982224092 scopus 로고    scopus 로고
    • Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity
    • Anstett K, Cutillas V, Fusco R, Mesplede T, Wainberg MA. Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity. J Antimicrob Chemother. 2016;71(8):2083-8.
    • (2016) J Antimicrob Chemother , vol.71 , Issue.8 , pp. 2083-2088
    • Anstett, K.1    Cutillas, V.2    Fusco, R.3    Mesplede, T.4    Wainberg, M.A.5
  • 61
    • 80052847754 scopus 로고    scopus 로고
    • Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes
    • Hightower KE, Wang R, Deanda F, Johns BA, Weaver K, Shen Y, et al. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes. Antimicrob Agents Chemother. 2011;55(10):4552-9.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.10 , pp. 4552-4559
    • Hightower, K.E.1    Wang, R.2    Deanda, F.3    Johns, B.A.4    Weaver, K.5    Shen, Y.6
  • 62
    • 84877843704 scopus 로고    scopus 로고
    • Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness
    • Abram ME, Hluhanich RM, Goodman DD, Andreatta KN, Margot NA, Ye L, et al. Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness. Antimicrob Agents Chemother. 2013;57(6):2654-63.
    • (2013) Antimicrob Agents Chemother , vol.57 , Issue.6 , pp. 2654-2663
    • Abram, M.E.1    Hluhanich, R.M.2    Goodman, D.D.3    Andreatta, K.N.4    Margot, N.A.5    Ye, L.6
  • 63
    • 84920131765 scopus 로고    scopus 로고
    • The R262K substitution combined with H51Y in HIV-1 subtype B integrase confers low-level resistance against dolutegravir
    • Cutillas V, Mesplede T, Anstett K, Hassounah S, Wainberg MA. The R262K substitution combined with H51Y in HIV-1 subtype B integrase confers low-level resistance against dolutegravir. Antimicrob Agents Chemother. 2015;59(1):310-6.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.1 , pp. 310-316
    • Cutillas, V.1    Mesplede, T.2    Anstett, K.3    Hassounah, S.4    Wainberg, M.A.5
  • 64
    • 84922448572 scopus 로고    scopus 로고
    • Evolution of a novel pathway leading to dolutegravir resistance in a patient harbouring N155H and multiclass drug resistance
    • Hardy I, Brenner B, Quashie P, Thomas R, Petropoulos C, Huang W, et al. Evolution of a novel pathway leading to dolutegravir resistance in a patient harbouring N155H and multiclass drug resistance. J Antimicrob Chemother. 2015;70(2):405-11.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.2 , pp. 405-411
    • Hardy, I.1    Brenner, B.2    Quashie, P.3    Thomas, R.4    Petropoulos, C.5    Huang, W.6
  • 65
    • 84908253044 scopus 로고    scopus 로고
    • Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity
    • Mesplede T, Osman N, Wares M, Quashie PK, Hassounah S, Anstett K, et al. Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity. J Antimicrob Chemother. 2014;69(10):2733-40.
    • (2014) J Antimicrob Chemother , vol.69 , Issue.10 , pp. 2733-2740
    • Mesplede, T.1    Osman, N.2    Wares, M.3    Quashie, P.K.4    Hassounah, S.5    Anstett, K.6
  • 66
    • 84892453291 scopus 로고    scopus 로고
    • The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness
    • Wares M, Mesplede T, Quashie PK, Osman N, Han Y, Wainberg MA. The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness. Retrovirology. 2014;11(1):7-14.
    • (2014) Retrovirology , vol.11 , Issue.1 , pp. 7-14
    • Wares, M.1    Mesplede, T.2    Quashie, P.K.3    Osman, N.4    Han, Y.5    Wainberg, M.A.6
  • 69
    • 84856111536 scopus 로고    scopus 로고
    • In vitro resistance selections using elvitegravir, raltegravir, and two metabolites of elvitegravir M1 and M4
    • Margot NA, Hluhanich RM, Jones GS, Andreatta KN, Tsiang M, McColl DJ, et al. In vitro resistance selections using elvitegravir, raltegravir, and two metabolites of elvitegravir M1 and M4. Antivir Res. 2012;93(2):288-96.
    • (2012) Antivir Res. , vol.93 , Issue.2 , pp. 288-296
    • Margot, N.A.1    Hluhanich, R.M.2    Jones, G.S.3    Andreatta, K.N.4    Tsiang, M.5    McColl, D.J.6
  • 71
    • 79957668616 scopus 로고    scopus 로고
    • Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143
    • Metifiot M, Vandegraaff N, Maddali K, Naumova A, Zhang X, Rhodes D, et al. Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143. Aids. 2011;25(9):1175-8.
    • (2011) Aids , vol.25 , Issue.9 , pp. 1175-1178
    • Metifiot, M.1    Vandegraaff, N.2    Maddali, K.3    Naumova, A.4    Zhang, X.5    Rhodes, D.6
  • 72
    • 62549166235 scopus 로고    scopus 로고
    • Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients
    • Malet I, Delelis O, Soulie C, Wirden M, Tchertanov L, Mottaz P, et al. Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients. J Antimicrob Chemother. 2009;63(4):795-804.
    • (2009) J Antimicrob Chemother , vol.63 , Issue.4 , pp. 795-804
    • Malet, I.1    Delelis, O.2    Soulie, C.3    Wirden, M.4    Tchertanov, L.5    Mottaz, P.6
  • 73
    • 70350666377 scopus 로고    scopus 로고
    • Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways
    • Fransen S, Gupta S, Danovich R, Hazuda D, Miller M, Witmer M, et al. Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways. J Virol. 2009;83(22):11440-6.
    • (2009) J Virol , vol.83 , Issue.22 , pp. 11440-11446
    • Fransen, S.1    Gupta, S.2    Danovich, R.3    Hazuda, D.4    Miller, M.5    Witmer, M.6
  • 74
    • 77957310350 scopus 로고    scopus 로고
    • Effect of raltegravir resistance mutations in HIV-1 integrase on viral fitness
    • Hu Z, Kuritzkes DR. Effect of raltegravir resistance mutations in HIV-1 integrase on viral fitness. J Acquir Immune Defic Syndr. 2010;55(2):148-55.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , Issue.2 , pp. 148-155
    • Hu, Z.1    Kuritzkes, D.R.2
  • 75
    • 84892766007 scopus 로고    scopus 로고
    • Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012
    • Hurt CB, Sebastian J, Hicks CB, Eron JJ. Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012. Clin Infect Dis. 2014;58(3):423-31.
    • (2014) Clin Infect Dis , vol.58 , Issue.3 , pp. 423-431
    • Hurt, C.B.1    Sebastian, J.2    Hicks, C.B.3    Eron, J.J.4
  • 76
    • 84864125870 scopus 로고    scopus 로고
    • Substitutions at amino acid positions 143, 148, and 155 of HIV-1 integrase define distinct genetic barriers to raltegravir resistance in vivo
    • Fransen S, Gupta S, Frantzell A, Petropoulos CJ, Huang W. Substitutions at amino acid positions 143, 148, and 155 of HIV-1 integrase define distinct genetic barriers to raltegravir resistance in vivo. J Virol. 2012;86(13):7249-55.
    • (2012) J Virol , vol.86 , Issue.13 , pp. 7249-7255
    • Fransen, S.1    Gupta, S.2    Frantzell, A.3    Petropoulos, C.J.4    Huang, W.5
  • 77
    • 33644863638 scopus 로고    scopus 로고
    • Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
    • Sato M, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, et al. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J Med Chem. 2006;49(5):1506-8.
    • (2006) J Med Chem , vol.49 , Issue.5 , pp. 1506-1508
    • Sato, M.1    Motomura, T.2    Aramaki, H.3    Matsuda, T.4    Yamashita, M.5    Ito, Y.6
  • 78
    • 77749267991 scopus 로고    scopus 로고
    • Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial
    • Zolopa AR, Berger DS, Lampiris H, Zhong L, Chuck SL, Enejosa JV, et al. Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial. J Infect Dis. 2010;201(6):814-22.
    • (2010) J Infect Dis , vol.201 , Issue.6 , pp. 814-822
    • Zolopa, A.R.1    Berger, D.S.2    Lampiris, H.3    Zhong, L.4    Chuck, S.L.5    Enejosa, J.V.6
  • 79
    • 84883385762 scopus 로고    scopus 로고
    • Dolutegravir pharmacokinetics in the genital tract and colorectum of HIV-negative men after single and multiple dosing
    • Greener BN, Patterson KB, Prince HM, Sykes CS, Adams JL, Dumond JB, et al. Dolutegravir pharmacokinetics in the genital tract and colorectum of HIV-negative men after single and multiple dosing. J Acquir Immune Defic Syndr. 2013;64(1):39-44.
    • (2013) J Acquir Immune Defic Syndr , vol.64 , Issue.1 , pp. 39-44
    • Greener, B.N.1    Patterson, K.B.2    Prince, H.M.3    Sykes, C.S.4    Adams, J.L.5    Dumond, J.B.6
  • 80
    • 77956017859 scopus 로고    scopus 로고
    • Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor
    • Bar-Magen T, Sloan RD, Donahue DA, Kuhl BD, Zabeida A, Xu H, et al. Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor. J Virol. 2010;84(18):9210-6.
    • (2010) J Virol , vol.84 , Issue.18 , pp. 9210-9216
    • Bar-Magen, T.1    Sloan, R.D.2    Donahue, D.A.3    Kuhl, B.D.4    Zabeida, A.5    Xu, H.6
  • 81
    • 85011968885 scopus 로고    scopus 로고
    • Different pathways leading to integrase inhibitors resistance
    • Thierry E, Deprez E, Delelis O. Different pathways leading to integrase inhibitors resistance. Front Microbiol. 2016;7:2165.
    • (2016) Front Microbiol. , vol.7 , pp. 2165
    • Thierry, E.1    Deprez, E.2    Delelis, O.3
  • 83
    • 84964969360 scopus 로고    scopus 로고
    • Might dolutegravir be part of a functional cure for HIV?
    • Wainberg MA, Han YS, Mesplede T. Might dolutegravir be part of a functional cure for HIV? Can J Microbiol. 2016;62(5):375-82.
    • (2016) Can J Microbiol , vol.62 , Issue.5 , pp. 375-382
    • Wainberg, M.A.1    Han, Y.S.2    Mesplede, T.3
  • 84
    • 84992322809 scopus 로고    scopus 로고
    • Profile of cabotegravir and its potential in the treatment and prevention of HIV-1 infection: evidence to date
    • Whitfield T, Torkington A, van Halsema C. Profile of cabotegravir and its potential in the treatment and prevention of HIV-1 infection: evidence to date. HIV AIDS (Auckl). 2016;8:157-64.
    • (2016) HIV AIDS (Auckl). , vol.8 , pp. 157-164
    • Whitfield, T.1    Torkington, A.2    Halsema, C.3
  • 85
    • 84930514309 scopus 로고    scopus 로고
    • Non-virological response to a dolutegravir-containing regimen in a patient harbouring a E157Q-mutated virus in the integrase region
    • Danion F, Belissa E, Peytavin G, Thierry E, Lanternier F, Scemla A, et al. Non-virological response to a dolutegravir-containing regimen in a patient harbouring a E157Q-mutated virus in the integrase region. J Antimicrob Chemother. 2015;70(6):1921-3.
    • (2015) J Antimicrob Chemother , vol.70 , Issue.6 , pp. 1921-1923
    • Danion, F.1    Belissa, E.2    Peytavin, G.3    Thierry, E.4    Lanternier, F.5    Scemla, A.6
  • 86
    • 84898987717 scopus 로고    scopus 로고
    • Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study
    • Castagna A, Maggiolo F, Penco G, Wright D, Mills A, Grossberg R, et al. Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study. J Infect Dis. 2014;210(3):354-62.
    • (2014) J Infect Dis , vol.210 , Issue.3 , pp. 354-362
    • Castagna, A.1    Maggiolo, F.2    Penco, G.3    Wright, D.4    Mills, A.5    Grossberg, R.6
  • 87
    • 84891500906 scopus 로고    scopus 로고
    • Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase
    • Quashie PK, Mesplede T, Han YS, Veres T, Osman N, Hassounah S, et al. Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase. Antimicrob Agents Chemother. 2014;58(1):633.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.1 , pp. 633
    • Quashie, P.K.1    Mesplede, T.2    Han, Y.S.3    Veres, T.4    Osman, N.5    Hassounah, S.6
  • 88
    • 84983102533 scopus 로고    scopus 로고
    • The dolutegravir R263K resistance mutation in HIV-1 integrase is incompatible with the emergence of resistance against raltegravir
    • Oliveira M, Mesplede T, Moisi D, Ibanescu RI, Brenner B, Wainberg MA. The dolutegravir R263K resistance mutation in HIV-1 integrase is incompatible with the emergence of resistance against raltegravir. AIDS. 2015;29(17):2255-60.
    • (2015) AIDS , vol.29 , Issue.17 , pp. 2255-2260
    • Oliveira, M.1    Mesplede, T.2    Moisi, D.3    Ibanescu, R.I.4    Brenner, B.5    Wainberg, M.A.6
  • 89
    • 84897975407 scopus 로고    scopus 로고
    • Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors
    • Oliveira M, Mesplede T, Quashie PK, Moisi D, Wainberg MA. Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors. AIDS. 2014;28(6):813-9.
    • (2014) AIDS , vol.28 , Issue.6 , pp. 813-819
    • Oliveira, M.1    Mesplede, T.2    Quashie, P.K.3    Moisi, D.4    Wainberg, M.A.5
  • 90
    • 84996619313 scopus 로고    scopus 로고
    • We need to use the best antiretroviral drugs worldwide to prevent HIV drug resistance
    • Brenner B, Wainberg MA. We need to use the best antiretroviral drugs worldwide to prevent HIV drug resistance. AIDS. 2016;30(17):2725-7.
    • (2016) AIDS , vol.30 , Issue.17 , pp. 2725-2727
    • Brenner, B.1    Wainberg, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.