메뉴 건너뛰기




Volumn 70, Issue 11, 2015, Pages 3087-3095

Virological failure to raltegravir in Spain: Incidence, prevalence and clinical consequences

(29)  Santos, José Ramón a,b   Blanco, José Luis c,o   Masiá, Mar d,e,p   Gutiérrez, Félix d,e,p   Pérez Elías, María Jesús f   Iribarren, José Antonio g   Force, Lluis h,q   Antela, Antonio i   Knobel, Hernando j   Salavert, Miguel k   De Quirós, Juan Carlos López Bernaldo l   Pino, María a,m   Paredes, Roger a,m,n   Clotet, Bonaventura a,b,m,n   Bravo, Isabel a   Martínez Picado, Javier a   Rojas, John F o   Gatell, José M o   Díaz, Alberto f   Gutiérrez, Carolina f   more..


Author keywords

[No Author keywords available]

Indexed keywords

DARUNAVIR PLUS RITONAVIR; DOLUTEGRAVIR; EMTRICITABINE; INTEGRASE; LAMIVUDINE; RALTEGRAVIR; TENOFOVIR; VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

EID: 84948977402     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkv205     Document Type: Article
Times cited : (10)

References (39)
  • 1
    • 84876289106 scopus 로고    scopus 로고
    • Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK
    • Rockstroh JK, DeJesus E, Lennox JL et al. Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK. J Acquir Immune Defic Syndr 2013; 63: 77-85.
    • (2013) J Acquir Immune Defic Syndr , vol.63 , pp. 77-85
    • Rockstroh, J.K.1    DeJesus, E.2    Lennox, J.L.3
  • 2
    • 80052905594 scopus 로고    scopus 로고
    • Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1-infected patients: 156-week results from STARTMRK
    • Rockstroh JK, Lennox JL, Dejesus E et al. Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1-infected patients: 156-week results from STARTMRK. Clin Infect Dis 2011; 53: 807-16.
    • (2011) Clin Infect Dis , vol.53 , pp. 807-816
    • Rockstroh, J.K.1    Lennox, J.L.2    Dejesus, E.3
  • 3
    • 47949120697 scopus 로고    scopus 로고
    • Raltegravir with optimized background therapy for resistant HIV-1 infection
    • Steigbigel RT, Cooper DA, Kumar PN et al. Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med 2008; 359: 339-54.
    • (2008) N Engl J Med , vol.359 , pp. 339-354
    • Steigbigel, R.T.1    Cooper, D.A.2    Kumar, P.N.3
  • 4
    • 75749107023 scopus 로고    scopus 로고
    • Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 phase III trials
    • Steigbigel RT, Cooper DA, Teppler H et al. Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 phase III trials. Clin Infect Dis 2010; 50: 605-12.
    • (2010) Clin Infect Dis , vol.50 , pp. 605-612
    • Steigbigel, R.T.1    Cooper, D.A.2    Teppler, H.3
  • 5
    • 72849119170 scopus 로고    scopus 로고
    • High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrug-resistant HIV: results of the ANRS 139 TRIO trial
    • Yazdanpanah Y, Fagard C, Descamps D et al. High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrug-resistant HIV: results of the ANRS 139 TRIO trial. Clin Infect Dis 2009; 49: 1441-9.
    • (2009) Clin Infect Dis , vol.49 , pp. 1441-1449
    • Yazdanpanah, Y.1    Fagard, C.2    Descamps, D.3
  • 6
    • 84897488732 scopus 로고    scopus 로고
    • November 2014
    • European AIDS Clinical Society (EACS). Guidelines, Version 7.1, November 2014. http://www.eacsociety.org/files/guidelines-7.1-english.pdf.
    • Guidelines, Version 7.1
  • 9
    • 84862843404 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial
    • DeJesus E, Rockstroh JK, Henry K et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet 2012; 379: 2429-38.
    • (2012) Lancet , vol.379 , pp. 2429-2438
    • DeJesus, E.1    Rockstroh, J.K.2    Henry, K.3
  • 10
    • 84862876886 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks
    • Sax PE, DeJesus E, Mills A et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet 2012; 379: 2439-48.
    • (2012) Lancet , vol.379 , pp. 2439-2448
    • Sax, P.E.1    DeJesus, E.2    Mills, A.3
  • 11
    • 84903295535 scopus 로고    scopus 로고
    • Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study
    • Clotet B, Feinberg J, van Lunzen J et al. Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study. Lancet 2014; 6736: 1-10.
    • (2014) Lancet , vol.6736 , pp. 1-10
    • Clotet, B.1    Feinberg, J.2    van Lunzen, J.3
  • 12
    • 84873633830 scopus 로고    scopus 로고
    • Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING study
    • Eron JJ, Clotet B, Durant J et al. Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING study. J Infect Dis 2013; 207: 740-8.
    • (2013) J Infect Dis , vol.207 , pp. 740-748
    • Eron, J.J.1    Clotet, B.2    Durant, J.3
  • 13
    • 84898987717 scopus 로고    scopus 로고
    • Dolutegravir in antiretroviralexperienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study
    • Castagna A, Maggiolo F, Penco G et al. Dolutegravir in antiretroviralexperienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study. J Infect Dis 2014; 210: 354-62.
    • (2014) J Infect Dis , vol.210 , pp. 354-362
    • Castagna, A.1    Maggiolo, F.2    Penco, G.3
  • 14
    • 55249105017 scopus 로고    scopus 로고
    • Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors
    • Goethals O, Clayton R, Van Ginderen M et al. Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol 2008; 82: 10366-74.
    • (2008) J Virol , vol.82 , pp. 10366-10374
    • Goethals, O.1    Clayton, R.2    Van Ginderen, M.3
  • 15
    • 84877843704 scopus 로고    scopus 로고
    • Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness
    • Abram ME, Hluhanich RM, Goodman DD et al. Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness. Antimicrob Agents Chemother 2013; 57: 2654-63.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2654-2663
    • Abram, M.E.1    Hluhanich, R.M.2    Goodman, D.D.3
  • 16
    • 79953200796 scopus 로고    scopus 로고
    • Transmitted resistance to HIV integrase strand-transfer inhibitors: right on schedule
    • Hurt CB. Transmitted resistance to HIV integrase strand-transfer inhibitors: right on schedule. Antivir Ther 2011; 16: 137-40.
    • (2011) Antivir Ther , vol.16 , pp. 137-140
    • Hurt, C.B.1
  • 17
    • 77955504896 scopus 로고    scopus 로고
    • Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy
    • Hatano H, Lampiris H, Fransen S et al. Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy. J Acquir Immune Defic Syndr 2010; 54: 389-93.
    • (2010) J Acquir Immune Defic Syndr , vol.54 , pp. 389-393
    • Hatano, H.1    Lampiris, H.2    Fransen, S.3
  • 18
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Cooper DA, Steigbigel RT, Gatell JM et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 2008; 359: 355-65.
    • (2008) N Engl J Med , vol.359 , pp. 355-365
    • Cooper, D.A.1    Steigbigel, R.T.2    Gatell, J.M.3
  • 19
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial
    • Lennox JL, DeJesus E, Lazzarin A et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009; 374: 796-806.
    • (2009) Lancet , vol.374 , pp. 796-806
    • Lennox, J.L.1    DeJesus, E.2    Lazzarin, A.3
  • 20
    • 79952692178 scopus 로고    scopus 로고
    • Prevalence and patterns of raltegravir resistance in treated patients in Europe [abstract]
    • Geretti A, Fearnhill E, Ceccherini-Silberstein F et al. Prevalence and patterns of raltegravir resistance in treated patients in Europe [abstract]. Antivir Ther 2010; 15: A62.
    • (2010) Antivir Ther , vol.15 , pp. A62
    • Geretti, A.1    Fearnhill, E.2    Ceccherini-Silberstein, F.3
  • 21
    • 84904559099 scopus 로고    scopus 로고
    • New raltegravir resistance pathways induce broad cross-resistance to all currently used integrase inhibitors
    • Malet I, Gimferrer Arriaga L, Artese A et al. New raltegravir resistance pathways induce broad cross-resistance to all currently used integrase inhibitors. J Antimicrob Chemother 2014; 69: 2118-22.
    • (2014) J Antimicrob Chemother , vol.69 , pp. 2118-2122
    • Malet, I.1    Gimferrer Arriaga, L.2    Artese, A.3
  • 22
    • 80155188567 scopus 로고    scopus 로고
    • Cross-resistance profile of the novel integrase inhibitor dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir
    • Canducci F, Ceresola ER, Boeri E et al. Cross-resistance profile of the novel integrase inhibitor dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir. J Infect Dis 2011; 204: 1811-5.
    • (2011) J Infect Dis , vol.204 , pp. 1811-1815
    • Canducci, F.1    Ceresola, E.R.2    Boeri, E.3
  • 23
    • 84904304980 scopus 로고    scopus 로고
    • Integrase genotypic and phenotypic predictors of antiviral response to dolutegravir (DTG) in subjects with resistance to integrase inhibitors (INIs)
    • Abstract 29, University of California, San Diego School Medicine, La Jolla, CA, USA
    • Vavro C, Huang J, Underwood M et al. Integrase genotypic and phenotypic predictors of antiviral response to dolutegravir (DTG) in subjects with resistance to integrase inhibitors (INIs). In: Abstracts of the International Workshop on HIV&Hepatitis Virus Drug Resistance and Curative Strategies, Toronto, ON, 2013. Abstract 29, p. 37. University of California, San Diego School Medicine, La Jolla, CA, USA.
    • In: Abstracts of the International Workshop on HIV&Hepatitis Virus Drug Resistance and Curative Strategies, Toronto, ON, 2013 , pp. 37
    • Vavro, C.1    Huang, J.2    Underwood, M.3
  • 24
    • 84892766007 scopus 로고    scopus 로고
    • Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012
    • Hurt CB, Sebastian J, Hicks CB et al. Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012. Clin Infect Dis 2014; 58: 423-31.
    • (2014) Clin Infect Dis , vol.58 , pp. 423-431
    • Hurt, C.B.1    Sebastian, J.2    Hicks, C.B.3
  • 25
    • 79953214552 scopus 로고    scopus 로고
    • Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy
    • Young B, Fransen S, Greenberg KS et al. Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy. Antivir Ther 2011; 16: 253-6.
    • (2011) Antivir Ther , vol.16 , pp. 253-256
    • Young, B.1    Fransen, S.2    Greenberg, K.S.3
  • 26
    • 79953189667 scopus 로고    scopus 로고
    • Transmitted raltegravir resistance in an HIV-1 CRF_AG-infected patient
    • Boyd SD, Maldarelli F, Sereti I et al. Transmitted raltegravir resistance in an HIV-1 CRF_AG-infected patient. Antivir Ther 2011; 16: 257-61.
    • (2011) Antivir Ther , vol.16 , pp. 257-261
    • Boyd, S.D.1    Maldarelli, F.2    Sereti, I.3
  • 27
    • 84864131448 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA Panel
    • Thompson MA, Aberg JA, Hoy JF et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA Panel. JAMA 2012; 308: 387-402.
    • (2012) JAMA , vol.308 , pp. 387-402
    • Thompson, M.A.1    Aberg, J.A.2    Hoy, J.F.3
  • 28
    • 33646744181 scopus 로고    scopus 로고
    • Web resources for HIV type 1 genotypic-resistance test interpretation
    • Liu TF, Shafer RW. Web resources for HIV type 1 genotypic-resistance test interpretation. Clin Infect Dis 2006; 42: 1608-18.
    • (2006) Clin Infect Dis , vol.42 , pp. 1608-1618
    • Liu, T.F.1    Shafer, R.W.2
  • 29
    • 84904536736 scopus 로고    scopus 로고
    • Phase 3 assessment of dolutegravir (DTG) 50 mg twice daily (BID) in HIV-1-infected subjects with raltegravir (RAL) and/or elvitegravir (EVG) resistance in VIKING-3: week 24 results of all 183 subjects enrolled
    • Abstract TULBPE19. International AIDS Society, Geneva, Switzerland
    • Nichols G, Lazzarin A, Maggiolo F et al. Phase 3 assessment of dolutegravir (DTG) 50 mg twice daily (BID) in HIV-1-infected subjects with raltegravir (RAL) and/or elvitegravir (EVG) resistance in VIKING-3: week 24 results of all 183 subjects enrolled. In: Abstracts of the Seventh IAS Conference on HIV Pathogenesis, Treatment and Prevention, Kuala Lumpur, 2013. Abstract TULBPE19. International AIDS Society, Geneva, Switzerland.
    • In: Abstracts of the Seventh IAS Conference on HIV Pathogenesis, Treatment and Prevention, Kuala Lumpur, 2013
    • Nichols, G.1    Lazzarin, A.2    Maggiolo, F.3
  • 31
    • 77956646683 scopus 로고    scopus 로고
    • Raltegravir versus efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses
    • Lennox JL, Dejesus E, Berger DS et al. Raltegravir versus efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses. J Acquir Immune Defic Syndr 2010; 55: 39-48.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , pp. 39-48
    • Lennox, J.L.1    Dejesus, E.2    Berger, D.S.3
  • 32
    • 81855166275 scopus 로고    scopus 로고
    • Raltegravir once daily or twice daily in previously untreated patients with HIV-1: a randomised, activecontrolled, phase 3 non-inferiority trial
    • Eron JJ, Rockstroh JK, Reynes J et al. Raltegravir once daily or twice daily in previously untreated patients with HIV-1: a randomised, activecontrolled, phase 3 non-inferiority trial. Lancet Infect Dis 2011; 11: 907-15.
    • (2011) Lancet Infect Dis , vol.11 , pp. 907-915
    • Eron, J.J.1    Rockstroh, J.K.2    Reynes, J.3
  • 33
    • 77649201378 scopus 로고    scopus 로고
    • Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study
    • Molina JM, Andrade-Villanueva J, Echevarria J et al. Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study. J Acquir Immune Defic Syndr 2010; 53: 323-32.
    • (2010) J Acquir Immune Defic Syndr , vol.53 , pp. 323-332
    • Molina, J.M.1    Andrade-Villanueva, J.2    Echevarria, J.3
  • 34
    • 49649092719 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48
    • Ortiz R, DeJesus E, Khanlou H et al. Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48. AIDS 2008; 22: 1389-97.
    • (2008) AIDS , vol.22 , pp. 1389-1397
    • Ortiz, R.1    DeJesus, E.2    Khanlou, H.3
  • 35
    • 73349134686 scopus 로고    scopus 로고
    • Abacavir-lamivudine versus tenofoviremtricitabine for initial HIV-1 therapy
    • Sax PE, Tierney C, Collier AC et al. Abacavir-lamivudine versus tenofoviremtricitabine for initial HIV-1 therapy. N Engl J Med 2009; 361: 2230-40.
    • (2009) N Engl J Med , vol.361 , pp. 2230-2240
    • Sax, P.E.1    Tierney, C.2    Collier, A.C.3
  • 36
    • 68649086238 scopus 로고    scopus 로고
    • Randomized, double-blind, placebomatched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment
    • Smith KY, Patel P, Fine D et al. Randomized, double-blind, placebomatched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment. AIDS 2009; 23: 1547-56.
    • (2009) AIDS , vol.23 , pp. 1547-1556
    • Smith, K.Y.1    Patel, P.2    Fine, D.3
  • 37
    • 17144377479 scopus 로고    scopus 로고
    • The effect of baseline CD4 cell count and HIV-1 viral load on the efficacy and safety of nevirapine or efavirenz-based first-line HAART
    • Van Leth F, Andrews S, Grinsztejn B et al. The effect of baseline CD4 cell count and HIV-1 viral load on the efficacy and safety of nevirapine or efavirenz-based first-line HAART. AIDS 2005; 19: 463-71.
    • (2005) AIDS , vol.19 , pp. 463-471
    • Van Leth, F.1    Andrews, S.2    Grinsztejn, B.3
  • 38
    • 34547403540 scopus 로고    scopus 로고
    • Predictors of disease progression in HIV infection: a review
    • Langford SE, Ananworanich J, Cooper DA. Predictors of disease progression in HIV infection: a review. AIDS Res Ther 2007; 4: 11.
    • (2007) AIDS Res Ther , vol.4 , pp. 11
    • Langford, S.E.1    Ananworanich, J.2    Cooper, D.A.3
  • 39
    • 84895534133 scopus 로고    scopus 로고
    • Factors related to changes in CD4+ T-cell counts over time in patients living with HIV/AIDS: a multilevel analysis
    • Montarroyos UR, Miranda-Filho DB, César CC et al. Factors related to changes in CD4+ T-cell counts over time in patients living with HIV/AIDS: a multilevel analysis. PLoS One 2014; 9: e84276.
    • (2014) PLoS One , vol.9
    • Montarroyos, U.R.1    Miranda-Filho, D.B.2    César, C.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.