-
1
-
-
80655148150
-
Evolutionary mechanisms of retroviral persistence
-
Whitney JB, Lim SY, Wainberg MA. Evolutionary mechanisms of retroviral persistence. AIDS Rev 2011; 13:234-239.
-
(2011)
AIDS Rev
, vol.13
, pp. 234-239
-
-
Whitney, J.B.1
Lim, S.Y.2
Wainberg, M.A.3
-
3
-
-
58149504194
-
Integrase and integration: Biochemical activities of HIV-1 integrase
-
Delelis O, Carayon K, Saib A, et al. Integrase and integration: biochemical activities of HIV-1 integrase. Retrovirology 2008; 5:114.
-
(2008)
Retrovirology
, vol.5
, pp. 114
-
-
Delelis, O.1
Carayon, K.2
Saib, A.3
-
5
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda DJ, Felock P, Witmer M, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000; 287:646- 650.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
-
6
-
-
84858409977
-
The structural biology of HIV-1: Mechanistic and therapeutic insights
-
Engelman A, Cherepanov P. The structural biology of HIV-1: mechanistic and therapeutic insights. Nat Rev Microbiol 2012; 10:279-290.
-
(2012)
Nat Rev Microbiol
, vol.10
, pp. 279-290
-
-
Engelman, A.1
Cherepanov, P.2
-
7
-
-
74549114178
-
Integrase inhibitors: A novel class of antiretroviral agents
-
Schafer JJ, Squires KE. Integrase inhibitors: A novel class of antiretroviral agents. Ann Pharmacother 2010; 44:145-156.
-
(2010)
Ann Pharmacother
, vol.44
, pp. 145-156
-
-
Schafer, J.J.1
Squires, K.E.2
-
8
-
-
47949114939
-
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
-
Cooper DA, Steigbigel RT, Gatell JM, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 2008; 359:355- 365.
-
(2008)
N Engl J Med
, vol.359
, pp. 355-365
-
-
Cooper, D.A.1
Steigbigel, R.T.2
Gatell, J.M.3
-
9
-
-
60849135152
-
Raltegravir and etravirine are active against HIV type 1 group O
-
Briz V, Garrido C, Poveda E, et al. Raltegravir and etravirine are active against HIV type 1 group O. AIDS Res Hum Retroviruses 2009; 25:225-227.
-
(2009)
AIDS Res Hum Retroviruses
, vol.25
, pp. 225-227
-
-
Briz, V.1
Garrido, C.2
Poveda, E.3
-
10
-
-
79952834794
-
Raltegravir: The first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium
-
Nguyen BY, Isaacs RD, Teppler H, et al. Raltegravir: The first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium. Ann N Y Acad Sci 2011; 1222:83-89.
-
(2011)
Ann N Y Acad Sci
, Issue.1222
, pp. 83-89
-
-
Nguyen, B.Y.1
Isaacs, R.D.2
Teppler, H.3
-
11
-
-
47949120697
-
Raltegravir with optimized background therapy for resistant HIV-1 infection
-
Steigbigel RT, Cooper DA, Kumar PN, et al. Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med 2008; 359:339-354.
-
(2008)
N Engl J Med
, vol.359
, pp. 339-354
-
-
Steigbigel, R.T.1
Cooper, D.A.2
Kumar, P.N.3
-
12
-
-
84856904753
-
Elvitegravir: A once-daily inhibitor of HIV-1 integrase
-
Wills T, Vega V. Elvitegravir: A once-daily inhibitor of HIV-1 integrase. Expert Opin Investig Drugs 2012; 21:395-401.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 395-401
-
-
Wills, T.1
Vega, V.2
-
14
-
-
53249087908
-
Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants
-
Kobayashi M, Nakahara K, Seki T, et al. Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antiviral Res 2008; 80:213-222.
-
(2008)
Antiviral Res
, vol.80
, pp. 213-222
-
-
Kobayashi, M.1
Nakahara, K.2
Seki, T.3
-
15
-
-
58149459588
-
Secondary mutations in viruses resistant to HIV-1 integrase inhibitors that restore viral infectivity and replication kinetics
-
Nakahara K, Wakasa-Morimoto C, Kobayashi M, et al. Secondary mutations in viruses resistant to HIV-1 integrase inhibitors that restore viral infectivity and replication kinetics. Antiviral Res 2009; 81:141-146.
-
(2009)
Antiviral Res
, vol.81
, pp. 141-146
-
-
Nakahara, K.1
Wakasa-Morimoto, C.2
Kobayashi, M.3
-
16
-
-
75749107023
-
Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatmentexperienced patients with drug-resistant HIV infection: Week 96 results of the BENCHMRK 1 and 2 phase III trials
-
Steigbigel RT, Cooper DA, Teppler H, et al. Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatmentexperienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 phase III trials. Clin Infect Dis 2010; 50:605- 612.
-
(2010)
Clin Infect Dis
, vol.50
, pp. 605-612
-
-
Steigbigel, R.T.1
Cooper, D.A.2
Teppler, H.3
-
17
-
-
79959574846
-
Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor
-
Goethals O, Van Ginderen M, Vos A, et al. Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor. Antiviral Res 2011; 91: 167-176
-
(2011)
Antiviral Res
, Issue.91
, pp. 167-176
-
-
Goethals, O.1
Van Ginderen, M.2
Vos, A.3
-
18
-
-
71049125354
-
Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes
-
Bar-Magen T, Sloan RD, Faltenbacher VH, et al. Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes. Retrovirology 2009; 6:103.
-
(2009)
Retrovirology
, vol.6
, pp. 103
-
-
Bar-Magen, T.1
Sloan, R.D.2
Faltenbacher, V.H.3
-
19
-
-
77956017859
-
Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor
-
Bar-Magen T, Sloan RD, Donahue DA, et al. Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor. J Virol 2010; 84:9210-9216.
-
(2010)
J Virol
, vol.84
, pp. 9210-9216
-
-
Bar-Magen, T.1
Sloan, R.D.2
Donahue, D.A.3
-
20
-
-
78650640149
-
Cross-resistance profile determination of two second-generation HIV-1 integrase inhibitors using a Panel Of Recombinant Viruses Derived From Raltegravir-treated Clinical Isolates
-
Van Wesenbeeck L Rondelez E Feyaerts M et al. Cross-resistance profile determination of two second-generation HIV-1 integrase inhibitors using a Panel Of Recombinant Viruses Derived From Raltegravir-treated Clinical Isolates. Antimicrob Agents Chemother 2011; 55321-325.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 321-325
-
-
Van Wesenbeeck, L.1
Rondelez, E.2
Feyaerts, M.3
-
21
-
-
79959244325
-
Effects of etravirine alone and with ritonavirboosted protease inhibitors on the pharmacokinetics of dolutegravir
-
Song I, Borland J, Min S, et al. Effects of etravirine alone and with ritonavirboosted protease inhibitors on the pharmacokinetics of dolutegravir. Antimicrob Agents Chemother 2011; 55:3517-3521.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 3517-3521
-
-
Song, I.1
Borland, J.2
Min, S.3
-
22
-
-
73849124557
-
Pharmacokinetics and safety of S/ GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers
-
Min S, Song I, Borland J, et al. Pharmacokinetics and safety of S/ GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers. Antimicrob Agents Chemother 2010; 54:254-258.
-
(2010)
Antimicrob Agents Chemother
, Issue.54
, pp. 254-258
-
-
Min, S.1
Song, I.2
Borland, J.3
-
23
-
-
80052399651
-
Antiviral activity, safety, and pharmacokinetics/ pharmacodynamics of dolutegravir as 10-day monotherapy in HIV-1- infected adults
-
Min S, Sloan L, Dejesus E, et al. Antiviral activity, safety, and pharmacokinetics/ pharmacodynamics of dolutegravir as 10-day monotherapy in HIV-1- infected adults. AIDS 2011; 25:1737-1745.
-
(2011)
AIDS
, vol.25
, pp. 1737-1745
-
-
Min, S.1
Sloan, L.2
Dejesus, E.3
-
24
-
-
78751697293
-
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor
-
.Kobayashi M, Yoshinaga T, Seki T, et al. In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor. Antimicrob Agents Chemother 2011; 55:813-821
-
Antimicrob Agents Chemother 2011
, vol.55
, pp. 813-821
-
-
Kobayashi, M.1
Yoshinaga, T.2
Seki, T.3
-
25
-
-
77953022020
-
Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with secondgeneration resistance profiles
-
Goethals O, Vos A, Van Ginderen M, et al. Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with secondgeneration resistance profiles. Virology 2010; 402:338-346.
-
(2010)
Virology
, vol.402
, pp. 338-346
-
-
Goethals, O.1
Vos, A.2
Van Ginderen, M.3
-
26
-
-
80052847538
-
Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572)
-
Hare S, Smith SJ, Metifiot M, et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol 2011; 80:565-572.
-
(2011)
Mol Pharmacol
, Issue.80
, pp. 565-572
-
-
Hare, S.1
Smith, S.J.2
Metifiot, M.3
-
28
-
-
84863393356
-
Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the secondgeneration integrase strand transfer inhibitor dolutegravir
-
Quashie PK, Mesplede T, Han YS, et al. Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the secondgeneration integrase strand transfer inhibitor dolutegravir. J Virol 2012; 86:2696-2705.
-
(2012)
J Virol
, vol.86
, pp. 2696-2705
-
-
Quashie, P.K.1
Mesplede, T.2
Han, Y.S.3
-
29
-
-
77957670046
-
Structure-based modeling of the functional HIV-1 intasome and its inhibition
-
Krishnan L, Li X, Naraharisetty HL, et al. Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proc Natl Acad Sci U S A 2010; 107:15910-15915.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 15910-15915
-
-
Krishnan, L.1
Li, X.2
Naraharisetty, H.L.3
-
30
-
-
77949365510
-
Retroviral intasome assembly and inhibition of DNA strand transfer
-
Hare S, Gupta SS, Valkov E, et al. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature 2010; 464:232-236.
-
(2010)
Nature
, Issue.464
, pp. 232-236
-
-
Hare, S.1
Gupta, S.S.2
Valkov, E.3
-
31
-
-
79953124784
-
Structural insights into the retroviral DNA integration apparatus
-
Cherepanov P, Maertens GN, Hare S. Structural insights into the retroviral DNA integration apparatus. Curr Opin Struct Biol 2011; 21:249-256.
-
(2011)
Curr Opin Struct Biol
, vol.21
, pp. 249-256
-
-
Cherepanov, P.1
Maertens, G.N.2
Hare, S.3
-
32
-
-
78149434355
-
The mechanism of retroviral integration from X-ray structures of its key intermediates
-
Maertens GN, Hare S, Cherepanov P. The mechanism of retroviral integration from X-ray structures of its key intermediates. Nature 2010; 468:326- 329.
-
(2010)
Nature
, vol.468
, pp. 326-329
-
-
Maertens, G.N.1
Hare, S.2
Cherepanov, P.3
-
33
-
-
12944270496
-
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
-
Espeseth AS, Felock P, Wolfe A, et al. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc Natl Acad Sci U S A 2000; 97:11244-11249.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11244-11249
-
-
Espeseth, A.S.1
Felock, P.2
Wolfe, A.3
-
34
-
-
78650533230
-
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
-
Hare S, Vos AM, Clayton RF, et al. Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A 2010; 107:20057-20062.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20057-20062
-
-
Hare, S.1
Vos, A.M.2
Clayton, R.F.3
-
35
-
-
0037076324
-
Diketo acid inhibitor mechanism and HIV- 1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
-
Grobler JA, Stillmock K, Hu B, et al. Diketo acid inhibitor mechanism and HIV- 1 integrase: implications for metal binding in the active site of phosphotransferase enzymes. Proc Natl Acad Sci U S A 2002; 99:6661-6666.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6661-6666
-
-
Grobler, J.A.1
Stillmock, K.2
Hu, B.3
-
36
-
-
84055217604
-
Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors
-
Bacchi A, Carcelli M, Compari C, et al. Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors. J Med Chem 2011; 54:8407- 8420.
-
(2011)
J Med Chem
, vol.54
, pp. 8407-8420
-
-
Bacchi, A.1
Carcelli, M.2
Compari, C.3
-
37
-
-
79953835779
-
HIV-1 IN strand transfer chelating inhibitors: A focus on metal binding
-
Bacchi A, Carcelli M, Compari C, et al. HIV-1 IN strand transfer chelating inhibitors: A focus on metal binding. Mol Pharm 2011; 8:507-519.
-
(2011)
Mol Pharm
, vol.8
, pp. 507-519
-
-
Bacchi, A.1
Carcelli, M.2
Compari, C.3
-
38
-
-
79954626457
-
HIV-1 integrase inhibitor resistance and its clinical implications
-
Blanco JL, Varghese V, Rhee SY, et al. HIV-1 integrase inhibitor resistance and its clinical implications. J Infect Dis 2011; 203:1204-1214.
-
(2011)
J Infect Dis
, vol.203
, pp. 1204-1214
-
-
Blanco, J.L.1
Varghese, V.2
Rhee, S.Y.3
-
39
-
-
53049101908
-
Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors
-
Dicker IB, Terry B, Lin Z, et al. Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors. J Biol Chem 2008; 283:23599- 23609.
-
(2008)
J Biol Chem
, vol.283
, pp. 23599-23609
-
-
Dicker, I.B.1
Terry, B.2
Lin, Z.3
-
40
-
-
55249105017
-
Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors
-
GoethalsO, Clayton R, VanGinderen M, et al. Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol 2008; 82:10366-10374.
-
(2008)
J Virol
, vol.82
, pp. 10366-10374
-
-
Goethals, O.1
Clayton, R.2
VanGinderen, M.3
-
41
-
-
78951476418
-
Resistance to inhibitors of the human immunodeficiency virus type 1 integration
-
Hazuda DJ. Resistance to inhibitors of the human immunodeficiency virus type 1 integration. Braz J Infect Dis 2010; 14:513-518.
-
(2010)
Braz J Infect Dis
, vol.14
, pp. 513-518
-
-
Hazuda, D.J.1
-
42
-
-
79957668616
-
Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143
-
Metifiot M, Vandegraaff N, Maddali K, et al. Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143. AIDS 2011; 25:1175- 1178.
-
(2011)
AIDS
, vol.25
, pp. 1175-1178
-
-
Metifiot, M.1
Vandegraaff, N.2
Maddali, K.3
-
43
-
-
33748879209
-
Rationale and uses of a public HIV drug-resistance database
-
Shafer RW. Rationale and uses of a public HIV drug-resistance database. J Infect Dis 2006; 194 (Suppl 1): S51-S58.
-
(2006)
J Infect Dis
, vol.194
, Issue.SUPPL. 1
-
-
Shafer, R.W.1
-
44
-
-
33644861936
-
Integration requires a Specific Interaction Of The Donor DNA Terminal 50-cytosine With Glutamine 148 Of The HIV-1 Integrase Flexible Loop
-
Johnson AA Santos W Pais GC et al. Integration requires a Specific Interaction Of The Donor DNA Terminal 50-cytosine With Glutamine 148 Of The HIV-1 Integrase Flexible Loop. J Biol Chem 2006; 281461- 467.
-
(2006)
J Biol Chem
, vol.281
, pp. 461-467
-
-
Johnson, A.A.1
Santos, W.2
Pais, G.C.3
-
45
-
-
79960341748
-
Identification of critical motifs within HIV-1 integrase required for importin alpha3 interaction and viral cDNA nuclear import
-
Jayappa KD, Ao Z, Yang M, et al. Identification of critical motifs within HIV-1 integrase required for importin alpha3 interaction and viral cDNA nuclear import. J Mol Biol 2011; 410:847-862.
-
(2011)
J Mol Biol
, vol.410
, pp. 847-862
-
-
Jayappa, K.D.1
Ao, Z.2
Yang, M.3
-
46
-
-
47249106450
-
Integrating medical abortion into safe abortion services: Experience from three pilot sites in South Africa
-
Kawonga M, Blanchard K, Cooper D, et al. Integrating medical abortion into safe abortion services: experience from three pilot sites in South Africa. J Fam Plann Reprod Healthcare 2008; 34:159-164.
-
(2008)
J Fam Plann Reprod Healthcare
, vol.34
, pp. 159-164
-
-
Kawonga, M.1
Blanchard, K.2
Cooper, D.3
-
47
-
-
80052847754
-
Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes
-
Hightower KE, Wang R, Deanda F, et al. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes. Antimicrob Agents Chemother 2011; 55:4552-4559.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 4552-4559
-
-
Hightower, K.E.1
Wang, R.2
Deanda, F.3
-
48
-
-
33748325882
-
Drug-target residence time and its implications for lead optimization
-
Copeland RA, Pompliano DL, Meek TD. Drug-target residence time and its implications for lead optimization. Nat Rev Drug Discov 2006; 5:730- 739.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 730-739
-
-
Copeland, R.A.1
Pompliano, D.L.2
Meek, T.D.3
-
49
-
-
0041922298
-
Peptides as new inhibitors of HIV-1 reverse transcriptase and integrase
-
de Soultrait VR, Desjobert C, Tarrago-Litvak L. Peptides as new inhibitors of HIV-1 reverse transcriptase and integrase. Curr Med Chem 2003; 10:1765- 1778.
-
(2003)
Curr Med Chem
, vol.10
, pp. 1765-1778
-
-
De Soultrait, V.R.1
Desjobert, C.2
Tarrago-Litvak, L.3
-
50
-
-
60349093648
-
Isolation of drug-resistant mutant HIV variants using tissue culture drug selection
-
Oliveira M, Brenner BG, Wainberg MA. Isolation of drug-resistant mutant HIV variants using tissue culture drug selection. Methods Mol Biol 2009; 485:427-433.
-
(2009)
Methods Mol Biol
, vol.485
, pp. 427-433
-
-
Oliveira, M.1
Brenner, B.G.2
Wainberg, M.A.3
-
51
-
-
34248203565
-
In vitro resistance profile of HIV-1 mutants selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303)
-
Jones G, Ledford R, Yu F, et al. In vitro resistance profile of HIV-1 mutants selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303). 14th CROI, Conference on Retroviruses and opportunistic infections, Los Angeles, California; 2007.
-
(2007)
14th CROI Conference on Retroviruses and opportunistic infections Los Angeles California
-
-
Jones, G.1
Ledford, R.2
Yu, F.3
-
52
-
-
37849002059
-
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
-
Shimura K, Kodama E, Sakagami Y, et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 2008; 82:764- 774.
-
(2008)
J Virol
, vol.82
, pp. 764-774
-
-
Shimura, K.1
Kodama, E.2
Sakagami, Y.3
-
53
-
-
78650238190
-
Dynamic escape of preexisting raltegravir-resistant HIV-1 from raltegravir selection pressure
-
Codoner FM, Pou C, Thielen A, et al. Dynamic escape of preexisting raltegravir-resistant HIV-1 from raltegravir selection pressure. Antiviral Res 2010; 88:281-286.
-
(2010)
Antiviral Res
, vol.88
, pp. 281-286
-
-
Codoner, F.M.1
Pou, C.2
Thielen, A.3
-
54
-
-
84856247092
-
Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: A refined analysis by ultra-deep 454 pyrosequencing
-
Armenia D, Vandenbroucke I, Fabeni L, et al. Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: A refined analysis by ultra-deep 454 pyrosequencing. J Infect Dis 2012; 205:557-567.
-
(2012)
J Infect Dis
, Issue.205
, pp. 557-567
-
-
Armenia, D.1
Vandenbroucke, I.2
Fabeni, L.3
-
55
-
-
84872649112
-
Evolution of IN inhibitor resistance mutations in patients failing elvitegravir-containing regimens. 19th CROI
-
Winters B, Lloyd RJ, Miller M, Holodniy M. Evolution of IN inhibitor resistance mutations in patients failing elvitegravir-containing regimens. 19th CROI, Conference on retroviruses and opportunistic infections, Seattle, WA 2012, Abstract: 701.
-
Conference on retroviruses and opportunistic infections, Seattle, WA 2012, Abstract
, vol.701
-
-
Winters, B.1
Lloyd, R.J.2
Miller, M.3
Holodniy, M.4
-
56
-
-
62349120391
-
Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies
-
Canducci F, Sampaolo M, Marinozzi MC, et al. Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies. AIDS 2009; 23:455-460.
-
(2009)
AIDS
, vol.23
, pp. 455-460
-
-
Canducci, F.1
Sampaolo, M.2
Marinozzi, M.C.3
-
57
-
-
54049102468
-
Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy
-
Charpentier C, Karmochkine M, Laureillard D, et al. Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy. HIV Med 2008; 9:765-770.
-
(2008)
HIV Med
, vol.9
, pp. 765-770
-
-
Charpentier, C.1
Karmochkine, M.2
Laureillard, D.3
-
58
-
-
70349337790
-
Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure
-
Fransen S, Karmochkine M, Huang W, et al. Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure. Antimicrob Agents Chemother 2009; 53:4522-4524.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 4522-4524
-
-
Fransen, S.1
Karmochkine, M.2
Huang, W.3
-
59
-
-
62549166235
-
Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients
-
Malet I, Delelis O, Soulie C, et al. Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients. J Antimicrob Chemother 2009; 63:795-804.
-
(2009)
J Antimicrob Chemother
, vol.63
, pp. 795-804
-
-
Malet, I.1
Delelis, O.2
Soulie, C.3
-
61
-
-
81855199761
-
The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02/AG HIV-1 subtype
-
Malet I, Fourati S, Charpentier C, et al. The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02/AG HIV-1 subtype. J Antimicrob Chemother 2011; 66:2827-2830.
-
(2011)
J Antimicrob Chemother
, vol.66
, pp. 2827-2830
-
-
Malet, I.1
Fourati, S.2
Charpentier, C.3
-
62
-
-
84872662557
-
-
Sato A, Seki T, Kobayashi M, et al. In vitro passage of drug resistant HIV-1 against a next generation integrase inhibitor (INI), S/GSK1349572. 49th ICAAC, San Francisco, CA; 2009.
-
(2009)
Vitro passage of drug resistant HIV-1 against a next generation integrase inhibitor (INI), S/GSK1349572. 49th ICAAC, San Francisco, CA
-
-
Sato, A.1
Seki, T.2
Kobayashi, M.3
-
63
-
-
84856111536
-
In vitro resistance selections using elvitegravir, raltegravir, and two metabolites of elvitegravir M1 and M4
-
Margot NA, Hluhanich RM, Jones GS, et al. In vitro resistance selections using elvitegravir, raltegravir, and two metabolites of elvitegravir M1 and M4. Antiviral Res 2012; 93:288-296.
-
(2012)
Antiviral Res
, vol.93
, pp. 288-296
-
-
Margot, N.A.1
Hluhanich, R.M.2
Jones, G.S.3
-
64
-
-
80155188567
-
Cross-resistance profile of the novel integrase inhibitor Dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir
-
Canducci F, Ceresola ER, Boeri E, et al. Cross-resistance profile of the novel integrase inhibitor Dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir. J Infect Dis 2011; 204:1811- 1815.
-
(2011)
J Infect Dis
, vol.204
, pp. 1811-1815
-
-
Canducci, F.1
Ceresola, E.R.2
Boeri, E.3
-
65
-
-
84872672515
-
Dolutegravir in combination therapy exhibits rapid and sustained antiviral response in ARV-naíve adults: 96-week results from SPRING-1 (ING112276)
-
Stellbrink HJ, Reynes J, Lazzarin A, et al. Dolutegravir in combination therapy exhibits rapid and sustained antiviral response in ARV-naíve adults: 96-week results from SPRING-1 (ING112276). 19th CROI, Conference on retroviruses and opportunistic infections, Seattle, WA 2012, Abstract: 102LB.
-
19th CROI, Conference on retroviruses and opportunistic infections, Seattle, WA 2012, Abstract: 102LB
-
-
Stellbrink, H.J.1
Reynes, J.2
Lazzarin, A.3
-
66
-
-
84856226017
-
Once daily dolutegravir (S/GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: Planned interim 48 week results from SPRING-1, a dose-ranging, randomised, phase 2b trial
-
.van Lunzen J, Maggiolo F, Arribas JR, et al. Once daily dolutegravir (S/GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: planned interim 48 week results from SPRING-1, a dose-ranging, randomised, phase 2b trial. Lancet Infect Dis 2012; 12:111-118
-
(2012)
Lancet Infect Dis
, Issue.12
, pp. 111-118
-
-
Van Lunzen, J.1
Maggiolo, F.2
Arribas, J.R.3
-
67
-
-
84872664403
-
-
Enron J, Kumar P, Lazzarin A, et al. DTG in subjects with HIV exhibiting RAL resistance: Functional monotherapy results of VIKING Study Cohort II. 18th CROI, Conference on retroviruses and opportunistic infections, Boston, MA 2011, Abstract: 151LB.
-
DTG In Subjects With HIV Exhibiting RAL Resistance: Functional Monotherapy Results Of VIKING Study Cohort II 18th CROI, Conference on retroviruses and opportunistic infections, Boston, MA 2011, Abstract: 151LB
-
-
Enron, J.1
Kumar, P.2
Lazzarin, A.3
-
68
-
-
84872658367
-
-
Antiviral Activity In Vitro Of The INI Dolutegravir Against Raltegravir-resistant HIV-2 Mutants
-
Kobayashi M, Seki T, Yoshinaga T, et al. Antiviral activity in vitro of the INI, dolutegravir, against raltegravir-resistant HIV-2 mutants. 19th CROI, Conference on retroviruses and opportunistic infections, Seattle, WA 2012, Abstract: 691.
-
19th CROI Conference On Retroviruses And Opportunistic Infections Seattle WA 2012 Abstract
, vol.691
-
-
Kobayashi, M.1
Seki, T.2
Yoshinaga, T.3
-
69
-
-
79953189667
-
Transmitted raltegravir resistance in an HIV-1 CRF/AG-infected patient
-
Boyd SD, Maldarelli F, Sereti I, et al. Transmitted raltegravir resistance in an HIV-1 CRF/AG-infected patient. Antivir Ther 2011; 16:257-261.
-
(2011)
Antivir Ther
, vol.16
, pp. 257-261
-
-
Boyd, S.D.1
Maldarelli, F.2
Sereti, I.3
-
70
-
-
79953214552
-
Transmission of integrase strandtransfer inhibitor multidrug-resistant HIV-1: Case report and response to raltegravir-containing antiretroviral therapy
-
Young B, Fransen S, Greenberg KS, et al. Transmission of integrase strandtransfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy. Antivir Ther 2011; 16:253-256.
-
(2011)
Antivir Ther
, vol.16
, pp. 253-256
-
-
Young, B.1
Fransen, S.2
Greenberg, K.S.3
-
71
-
-
79953200796
-
Transmitted resistance to HIV integrase strand-transfer inhibitors: Right on schedule
-
Hrt CB. Transmitted resistance to HIV integrase strand-transfer inhibitors: right on schedule. Antivir Ther 2011; 16:137-140.
-
(2011)
Antivir Ther
, vol.16
, pp. 137-140
-
-
Hurt, C.B.1
|