Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Science

Volumn 355, Issue 6320, 2017, Pages

  Passos, Dario Oliveira ^a   Li, Min ^b   Yang, Renbin ^b   Rebensburg, Stephanie V ^c   Ghirlando, Rodolfo ^b   Jeon, Youngmin ^a   Shkriabai, Nikoloz ^c   Kvaratskhelia, Mamuka ^c   Craigie, Robert ^b   Lyumkis, Dmitry ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; HYBRID PROTEIN; INTASOME; INTEGRASE; NUCLEOPROTEIN; OLIGOMER; TETRAMER; UNCLASSIFIED DRUG; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VIRUS DNA; VIRUS RNA;

CRYSTAL STRUCTURE; GENETIC ANALYSIS; GENOME; HUMAN IMMUNODEFICIENCY VIRUS; NUMERICAL MODEL; PROTEIN;

AMINO TERMINAL SEQUENCE; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYOELECTRON MICROSCOPY; DNA BINDING; DNA INTEGRATION; DNA STRAND; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MOLECULAR MODEL; MOUSE MAMMARY TUMOR VIRUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYLOGENETIC TREE; POINT MUTATION; PRIORITY JOURNAL; ROUS SARCOMA VIRUS; SPUMAVIRUS; STRAND TRANSFER COMPLEX; ULTRACENTRIFUGATION; VIROGENESIS; VIRUS REPLICATION; VISNA VIRUS; CHEMISTRY; HUMAN; PHYSIOLOGY; PROTEIN DOMAIN; ULTRASTRUCTURE; VIRUS DNA CELL DNA INTERACTION; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; DNA, VIRAL; HIV INTEGRASE; HIV-1; HUMANS; MODELS, MOLECULAR; NUCLEOPROTEINS; PROTEIN DOMAINS; RNA, VIRAL; VIRUS INTEGRATION;

EID: 85009289750     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah5163     Document Type: Article

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