Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor

Journal of Virology

Volumn 84, Issue 18, 2010, Pages 9210-9216

  Bar Magen, Tamara ^a   Sloan, Richard D ^a   Donahue, Daniel A ^a,b   Kuhl, Björn D ^a,b   Zabeida, Alexandra ^a   Xu, Hongtao ^a   Oliveira, Maureen ^a   Hazuda, Daria J ^c   Wainberg, Mark A ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ELVITEGRAVIR; INTEGRASE; INTEGRASE INHIBITOR; MAGNESIUM ION; MK 2048; RALTEGRAVIR; UNCLASSIFIED DRUG; VIRUS DNA; 2 PYRROLIDONE DERIVATIVE; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; QUINOLONE DERIVATIVE; VIRUS RNA;

ANTIVIRAL RESISTANCE; ARTICLE; CATALYSIS; COMPUTER MODEL; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VIRUS DNA CELL DNA INTERACTION; VIRUS REPLICATION; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, VIRAL; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; PYRROLIDINONES; QUINOLONES; RNA, VIRAL; VIRUS REPLICATION;

EID: 77956017859     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01164-10     Document Type: Article

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