Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

Retrovirology

Volumn 10, Issue 1, 2013, Pages

  Mesplède, Thibault ^a   Quashie, Peter K ^a,b   Osman, Nathan ^a   Han, Yingshan ^a   Singhroy, Diane N ^a,c   Lie, Yolanda ^d   Petropoulos, Christos J ^d   Huang, Wei ^d   Wainberg, Mark A ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MONOGRAM BIOSCIENCES   (United States)

Author keywords

Dolutegravir; HIV integrase; Resistance to antiretrovirals; Strand transfer assay; Viral fitness

Indexed keywords

DOLUTEGRAVIR; EFAVIRENZ; ELVITEGRAVIR; INTEGRASE; RALTEGRAVIR; VIRUS DNA;

ANTIVIRAL RESISTANCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IC 50; INFECTION PREVENTION; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; VIRAL FITNESS; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS VIRULENCE; WILD TYPE;

ANTI-HIV AGENTS; DRUG RESISTANCE, VIRAL; HETEROCYCLIC COMPOUNDS, 3-RING; HIV INTEGRASE; HIV-1; HUMANS; MUTATION, MISSENSE; POINT MUTATION; SELECTION, GENETIC; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84874039772     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-22     Document Type: Article

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