Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology

SLAS Discovery

Volumn 22, Issue 5, 2017, Pages 571-582

  Ley, Svenja ^a   Galuba, Olaf ^a   Salathe, Adrian ^a   Melin, Nicolas ^a   Aebi, Alexandra ^a   Pikiolek, Monika ^a   Knehr, Judith ^a   Carbone, Walter ^a   Beibel, Martin ^a   Nigsch, Florian ^a   Roma, Guglielmo ^a   d’Ario, Giovanni ^a   Kirkland, Susan ^a   Bouchez, Laure C ^a   Gubser Keller, Caroline ^a   Bouwmeester, Tewis ^a   Parker, Christian N ^a   Ruffner, Heinz ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

KGF; mucositis; primary 3D cell cultures; RSPO; small intestinal crypt organoids

Indexed keywords

DIMETHYL SULFOXIDE; KERATINOCYTE GROWTH FACTOR; MESSENGER RNA; PALIFERMIN; THROMBOSPONDIN; TRANSCRIPTOME;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; INTESTINE CRYPT; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MICROARRAY ANALYSIS; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; POLYMERASE CHAIN REACTION; RADIATION INJURY; RADIOSENSITIVITY; RNA SEQUENCE; STEM CELL TRANSPLANTATION; TRANSLATION INITIATION; ANIMAL; C57BL MOUSE; CELL CULTURE TECHNIQUE; DRUG EFFECT; DRUG SCREENING; INTESTINE; INTESTINE MUCOSA; METABOLISM; ORGANOID; PHYSIOLOGY; PROCEDURES;

ANIMALS; CELL CULTURE TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLAST GROWTH FACTOR 7; INTESTINAL MUCOSA; INTESTINES; MICE; MICE, INBRED C57BL; ORGANOIDS; THROMBOSPONDINS; TRANSCRIPTOME;

EID: 85019705713     PISSN: 24725552     EISSN: 24725560     Source Type: Journal    
DOI: 10.1177/2472555216683651     Document Type: Article

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