PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

Journal of Clinical Investigation

Volumn 122, Issue 8, 2012, Pages 2827-2836

  Xie, Liang ^a   Pi, Xinchun ^a   Mishra, Ashutosh ^b   Fong, Guohua ^c   Peng, Junmin ^b   Patterson, Cam ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; CASPASE 3; DIMETHYLOXALOYLGLYCINE; OXYGENASE INHIBITOR; PROLYL HYDROXYLASE DOMAIN PROTEIN 3; PROTEIN; PROTEIN BCL XL; PROTEIN P53; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR CLOCK2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA DAMAGE RESPONSE; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; GENOMIC INSTABILITY; HYDROXYLATION; HYPOXIA; IONIZING RADIATION; LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; S PHASE CELL CYCLE CHECKPOINT; TANDEM MASS SPECTROMETRY; THYMOCYTE; THYMUS; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; CELL CYCLE PROTEINS; DIOXYGENASES; DNA DAMAGE; FEMALE; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864766822     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI62374     Document Type: Article

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