Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Wang, Xinwei ^a,b   Wei, Liang ^a,b   Cramer, Julie M ^a   Leibowitz, Brian J ^a,b   Judge, Colleen ^a,b   Epperly, Michael ^a,b   Greenberger, Joel ^a,b   Wang, Fengchao ^c   Li, Linheng ^c   Stelzner, Matthias G ^d   Dunn, James C Y ^e   Martin, Martin G ^e   Lagasse, Eric ^a   Zhang, Lin ^a,b   Yu, Jian ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; APOPTOSIS REGULATORY PROTEIN; G PROTEIN COUPLED RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; LGR5 PROTEIN, MOUSE; PROTEIN P53; PUMA PROTEIN, MOUSE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RADIOPROTECTIVE AGENT; TUMOR SUPPRESSOR PROTEIN;

ACETYLATION; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL CULTURE; CYTOLOGY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; EXPERIMENTAL RADIATION INJURY; GASTROINTESTINAL DISEASES; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTESTINE; IONIZING RADIATION; KNOCKOUT MOUSE; METABOLISM; MOUSE; RADIATION RESPONSE; RADIATION TOLERANCE; RADIOTHERAPY; STEM CELL;

ACETYLATION; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GASTROINTESTINAL DISEASES; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTESTINES; MICE; MICE, KNOCKOUT; PYRIDINES; PYRIMIDINES; RADIATION INJURIES, EXPERIMENTAL; RADIATION TOLERANCE; RADIATION, IONIZING; RADIATION-PROTECTIVE AGENTS; RADIOTHERAPY; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84927606256     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep08566     Document Type: Article

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