Tricyclic aminopyrimidine histamine H4 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6577-6581

  Savall, Brad M ^a   Gomez, Laurent ^b   Chavez, Frank ^c   Curtis, Michael ^d   Meduna, Steven P ^a   Kearney, Aaron ^a   Dunford, Paul ^a   Cowden, Jeffery ^a   Thurmond, Robin L ^a   Grice, Cheryl ^a   Edwards, James P ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b DART NEUROSCIENCE LLC   (United States)

^c AMGEN INC   (United States)

^d ZOETIS   (United States)

Author keywords

Amino pyrimidine; Antagonists; Benzofuran; Histamine; Histamine H4; Tricyclic

Indexed keywords

AMINOPYRIMIDINE DERIVATIVE; HISTAMINE H4 RECEPTOR ANTAGONIST; JNJ 28307474; JNJ 40279486; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG SOLUBILITY; DRUG STABILITY; EOSINOPHIL; LYMPHOCYTE; MACROPHAGE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NEUTROPHIL; NONHUMAN; PHYSICOCHEMICAL MODEL; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 80054792019     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.014     Document Type: Article

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