A New Class of Molecular Targeted Radioprotectors: GSK-3β Inhibitors

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 2, 2010, Pages 557-565

  Thotala, Dinesh K ^a   Geng, Ling ^a   Dickey, Amy K ^a   Hallahan, Dennis E ^c,d   Yazlovitskaya, Eugenia M ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c USA   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; GSK inhibitors; Intestinal injury; Ionizing irradiation; Radioprotection

Indexed keywords

ANNEXINS; APOPTOSIS; APOPTOSIS ASSAYS; CASPASE-3; CLONOGENIC SURVIVAL; GLYCOGEN SYNTHASE KINASE-3; IMMUNOBLOT ANALYSIS; IMMUNOHISTOCHEMICAL STAINING; IN-CELL; IN-VIVO; INTESTINAL EPITHELIAL CELLS; IONIZING IRRADIATION; MOLECULAR MECHANISM; PRE-TREATMENT; QUALITY OF LIFE; RADIATION THERAPY; RADIATION-INDUCED; RADIATION-INDUCED APOPTOSIS; RADIATION-INDUCED DAMAGES; RADIOPROTECTION; RADIOPROTECTIVE AGENTS; RADIOPROTECTORS; SMALL INTESTINE; SMALL-MOLECULE INHIBITORS;

ANTIBIOTICS; ASSAYS; CELL CULTURE; CELL DEATH; IRRADIATION; RADIATION PROTECTION;

RADIATION;

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; BETA CATENIN; CASPASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; RADIOPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CELL CULTURE; CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; EPITHELIUM CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE INJURY; IRRADIATION; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTECTION; QUALITY OF LIFE; RADIATION; RAT; SMALL INTESTINE; SURVIVAL;

AMINOPHENOLS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BETA CATENIN; CASPASE 3; CELL LINE; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE 3; IN SITU NICK-END LABELING; INDOLES; INTESTINES; MALEIMIDES; MICE; MICE, INBRED C57BL; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; RATS;

EID: 73649148033     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.09.024     Document Type: Article

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