-
1
-
-
84888439466
-
Immune mechanisms in type 1 diabetes
-
Wallberg M, Cooke A. Immune mechanisms in type 1 diabetes. Trends Immunol. 2013;34(12):583-591.
-
(2013)
Trends Immunol.
, vol.34
, Issue.12
, pp. 583-591
-
-
Wallberg, M.1
Cooke, A.2
-
2
-
-
79959386535
-
How does type 1 diabetes develop?: The notion of homicide or β-cell suicide revisited
-
Atkinson MA, et al. How does type 1 diabetes develop?: The notion of homicide or β-cell suicide revisited. Diabetes. 2011;60(5):1370-1379.
-
(2011)
Diabetes.
, vol.60
, Issue.5
, pp. 1370-1379
-
-
Atkinson, M.A.1
-
3
-
-
61849139579
-
Fasting plasma C-peptide and micro-and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients
-
Panero F, et al. Fasting plasma C-peptide and micro-and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients. Diabetes Care. 2009;32(2):301-305.
-
(2009)
Diabetes Care.
, vol.32
, Issue.2
, pp. 301-305
-
-
Panero, F.1
-
4
-
-
0034945790
-
C-peptide prevents and improves chronic Type i diabetic polyneuropathy in the BB/Wor rat
-
Sima AA, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001;44(7):889-897.
-
(2001)
Diabetologia.
, vol.44
, Issue.7
, pp. 889-897
-
-
Sima, A.A.1
-
5
-
-
0026558822
-
The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients
-
Johansson BL, Sjöberg S, Wahren J. The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients. Diabetologia. 1992;35(2):121-128.
-
(1992)
Diabetologia.
, vol.35
, Issue.2
, pp. 121-128
-
-
Johansson, B.L.1
Sjöberg, S.2
Wahren, J.3
-
6
-
-
0026488266
-
Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients
-
Johansson BL, Linde B, Wahren J. Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients. Diabetologia. 1992;35(12):1151-1158.
-
(1992)
Diabetologia.
, vol.35
, Issue.12
, pp. 1151-1158
-
-
Johansson, B.L.1
Linde, B.2
Wahren, J.3
-
7
-
-
84891350009
-
C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes
-
Bhatt MP, Lim YC, Kim YM, Ha KS. C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes. Diabetes. 2013;62(11):3851-3862.
-
(2013)
Diabetes.
, vol.62
, Issue.11
, pp. 3851-3862
-
-
Bhatt, M.P.1
Lim, Y.C.2
Kim, Y.M.3
Ha, K.S.4
-
8
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro AM, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343(4):230-238.
-
(2000)
N Engl J Med.
, vol.343
, Issue.4
, pp. 230-238
-
-
Shapiro, A.M.1
-
9
-
-
41849151748
-
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
-
Kroon E, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008;26(4):443-452.
-
(2008)
Nat Biotechnol.
, vol.26
, Issue.4
, pp. 443-452
-
-
Kroon, E.1
-
10
-
-
80051473845
-
Anti-CD3 antibodies for type 1 diabetes: Beyond expectations
-
Bach JF. Anti-CD3 antibodies for type 1 diabetes: beyond expectations. Lancet. 2011;378(9790):459-460.
-
(2011)
Lancet.
, vol.378
, Issue.9790
, pp. 459-460
-
-
Bach, J.F.1
-
11
-
-
84856564903
-
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
-
Ludvigsson J, et al. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N Engl J Med. 2012;366(5):433-442.
-
(2012)
N Engl J Med.
, vol.366
, Issue.5
, pp. 433-442
-
-
Ludvigsson, J.1
-
12
-
-
79960912796
-
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: A randomised, double-blind, placebocontrolled trial
-
Orban T, et al. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: A randomised, double-blind, placebocontrolled trial. Lancet. 2011;378(9789):412-419.
-
(2011)
Lancet.
, vol.378
, Issue.9789
, pp. 412-419
-
-
Orban, T.1
-
13
-
-
79960743608
-
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial
-
Wherrett DK, et al. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial. Lancet. 2011;378(9788):319-327.
-
(2011)
Lancet.
, vol.378
, Issue.9788
, pp. 319-327
-
-
Wherrett, D.K.1
-
14
-
-
33749070784
-
International trial of the Edmonton protocol for islet transplantation
-
Shapiro AM, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006;355(13):1318-1330.
-
(2006)
N Engl J Med.
, vol.355
, Issue.13
, pp. 1318-1330
-
-
Shapiro, A.M.1
-
15
-
-
78751662679
-
Type 1 diabetes: Etiology, immunology, and therapeutic strategies
-
van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev. 2011;91(1):79-118.
-
(2011)
Physiol Rev.
, vol.91
, Issue.1
, pp. 79-118
-
-
Van Belle, T.L.1
Coppieters, K.T.2
Von Herrath, M.G.3
-
16
-
-
77954128990
-
Immune cell crosstalk in type 1 diabetes
-
Lehuen A, Diana J, Zaccone P, Cooke A. Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol. 2010;10(7):501-513.
-
(2010)
Nat Rev Immunol.
, vol.10
, Issue.7
, pp. 501-513
-
-
Lehuen, A.1
Diana, J.2
Zaccone, P.3
Cooke, A.4
-
17
-
-
0022640843
-
Two types of murine helper T cell clone
-
Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136(7):2348-2357.
-
(1986)
I. Definition According to Profiles of Lymphokine Activities and Secreted Proteins. J Immunol.
, vol.136
, Issue.7
, pp. 2348-2357
-
-
Mosmann, T.R.1
Cherwinski, H.2
Bond, M.W.3
Giedlin, M.A.4
Coffman, R.L.5
-
18
-
-
0029847368
-
Functional diversity of helper T lymphocytes
-
Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 1996;383(6603):787-793.
-
(1996)
Nature.
, vol.383
, Issue.6603
, pp. 787-793
-
-
Abbas, A.K.1
Murphy, K.M.2
Sher, A.3
-
19
-
-
34948897493
-
High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes
-
Stechova K, et al. High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes. Diabetes Metab Res Rev. 2007;23(6):462-471.
-
(2007)
Diabetes Metab Res Rev.
, vol.23
, Issue.6
, pp. 462-471
-
-
Stechova, K.1
-
20
-
-
42249084849
-
Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category
-
Luger D, et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205(4):799-810.
-
(2008)
J Exp Med.
, vol.205
, Issue.4
, pp. 799-810
-
-
Luger, D.1
-
21
-
-
29244482759
-
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
-
Tang Q, et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006;7(1):83-92.
-
(2006)
Nat Immunol.
, vol.7
, Issue.1
, pp. 83-92
-
-
Tang, Q.1
-
22
-
-
34748917229
-
Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes
-
Norris JM, et al. Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA. 2007;298(12):1420-1428.
-
(2007)
JAMA.
, vol.298
, Issue.12
, pp. 1420-1428
-
-
Norris, J.M.1
-
23
-
-
0642307067
-
Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: A large, population-based, case-control study
-
Norwegian Childhood Diabetes Study Group
-
Stene LC, Joner G, Norwegian Childhood Diabetes Study Group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: A large, population-based, case-control study. Am J Clin Nutr. 2003;78(6):1128-1134.
-
(2003)
Am J Clin Nutr.
, vol.78
, Issue.6
, pp. 1128-1134
-
-
Stene, L.C.1
Joner, G.2
-
24
-
-
84928825184
-
Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes
-
Chase HP, et al. Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes. Pediatr Diabetes. 2015;16(4):271-279.
-
(2015)
Pediatr Diabetes.
, vol.16
, Issue.4
, pp. 271-279
-
-
Chase, H.P.1
-
25
-
-
77449141236
-
Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death
-
Wei D, et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes. 2010;59(2):471-478.
-
(2010)
Diabetes.
, vol.59
, Issue.2
, pp. 471-478
-
-
Wei, D.1
-
26
-
-
70349330020
-
Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice
-
Norquay LD, et al. Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology. 2009;150(10):4531-4540.
-
(2009)
Endocrinology.
, vol.150
, Issue.10
, pp. 4531-4540
-
-
Norquay, L.D.1
-
27
-
-
84908134654
-
A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes
-
Ferris ST, Carrero JA, Mohan JF, Calderon B, Murphy KM, Unanue ER. A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes. Immunity. 2014;41(4):657-669.
-
(2014)
Immunity.
, vol.41
, Issue.4
, pp. 657-669
-
-
Ferris, S.T.1
Carrero, J.A.2
Mohan, J.F.3
Calderon, B.4
Murphy, K.M.5
Unanue, E.R.6
-
28
-
-
17644361955
-
The NOD mouse: A model of immune dysregulation
-
Anderson MS, Bluestone JA. The NOD mouse: A model of immune dysregulation. Annu Rev Immunol. 2005;23:447-485.
-
(2005)
Annu Rev Immunol.
, vol.23
, pp. 447-485
-
-
Anderson, M.S.1
Bluestone, J.A.2
-
29
-
-
0031952961
-
Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation
-
Fox CJ, Danska JS. Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation. Diabetes. 1998;47(3):331-338.
-
(1998)
Diabetes.
, vol.47
, Issue.3
, pp. 331-338
-
-
Fox, C.J.1
Danska, J.S.2
-
30
-
-
1942451803
-
Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice
-
Makhlouf L, et al. Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice. Transplantation. 2004;77(7):990-997.
-
(2004)
Transplantation.
, vol.77
, Issue.7
, pp. 990-997
-
-
Makhlouf, L.1
-
31
-
-
75349111902
-
Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients
-
p520/521 Study Group
-
Pfleger C, Meierhoff G, Kolb H, Schloot NC, p520/521 Study Group. Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients. J Autoimmun. 2010;34(2):127-135.
-
(2010)
J Autoimmun.
, vol.34
, Issue.2
, pp. 127-135
-
-
Pfleger, C.1
Meierhoff, G.2
Kolb, H.3
Schloot, N.C.4
-
32
-
-
70349755645
-
How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets
-
Feuerer M, Shen Y, Littman DR, Benoist C, Mathis D. How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity. 2009;31(4):654-664.
-
(2009)
Immunity.
, vol.31
, Issue.4
, pp. 654-664
-
-
Feuerer, M.1
Shen, Y.2
Littman, D.R.3
Benoist, C.4
Mathis, D.5
-
33
-
-
12144249838
-
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
-
Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes. 2005;54(1):92-99.
-
(2005)
Diabetes.
, vol.54
, Issue.1
, pp. 92-99
-
-
Lindley, S.1
Dayan, C.M.2
Bishop, A.3
Roep, B.O.4
Peakman, M.5
Tree, T.I.6
-
34
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6(11):1133-1141.
-
(2005)
Nat Immunol.
, vol.6
, Issue.11
, pp. 1133-1141
-
-
Park, H.1
-
35
-
-
66649113381
-
Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice
-
Emamaullee JA, et al. Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes. 2009;58(6):1302-1311.
-
(2009)
Diabetes.
, vol.58
, Issue.6
, pp. 1302-1311
-
-
Emamaullee, J.A.1
-
36
-
-
84858700052
-
Omega-3 fatty acids and their lipid mediators: Towards an understanding of resolvin and protectin formation
-
Weylandt KH, Chiu CY, Gomolka B, Waechter SF, Wiedenmann B. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. Prostaglandins Other Lipid Mediat. 2012;97(3-4):73-82.
-
(2012)
Prostaglandins Other Lipid Mediat.
, vol.97
, Issue.3-4
, pp. 73-82
-
-
Weylandt, K.H.1
Chiu, C.Y.2
Gomolka, B.3
Waechter, S.F.4
Wiedenmann, B.5
-
37
-
-
39749122734
-
The opposing effects of n-3 and n-6 fatty acids
-
Schmitz G, Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res. 2008;47(2):147-155.
-
(2008)
Prog Lipid Res.
, vol.47
, Issue.2
, pp. 147-155
-
-
Schmitz, G.1
Ecker, J.2
-
38
-
-
84884948469
-
MTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression
-
Chen Z, et al. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene. 2014;33(37):4548-4557.
-
(2014)
Oncogene.
, vol.33
, Issue.37
, pp. 4548-4557
-
-
Chen, Z.1
-
39
-
-
84890137621
-
T cell exit from quiescence and differentiation into Th2 cells depend on RaptormTORC1-mediated metabolic reprogramming
-
Yang K, et al. T cell exit from quiescence and differentiation into Th2 cells depend on RaptormTORC1-mediated metabolic reprogramming. Immunity. 2013;39(6):1043-1056.
-
(2013)
Immunity.
, vol.39
, Issue.6
, pp. 1043-1056
-
-
Yang, K.1
-
40
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe GM, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol. 2011;12(4):295-303.
-
(2011)
Nat Immunol.
, vol.12
, Issue.4
, pp. 295-303
-
-
Delgoffe, G.M.1
-
41
-
-
84860237060
-
Regulation and function of mTOR signalling in T cell fate decisions
-
Chi H. Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol. 2012;12(5):325-338.
-
(2012)
Nat Rev Immunol.
, vol.12
, Issue.5
, pp. 325-338
-
-
Chi, H.1
-
42
-
-
0031037689
-
Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis
-
Spychalla JP, Kinney AJ, Browse J. Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis. Proc Natl Acad Sci U S A. 1997;94(4):1142-1147.
-
(1997)
Proc Natl Acad Sci U S A.
, vol.94
, Issue.4
, pp. 1142-1147
-
-
Spychalla, J.P.1
Kinney, A.J.2
Browse, J.3
-
43
-
-
84928811876
-
Predictors of Progression from the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)
-
Steck AK, et al. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015;38(5):808-813.
-
(2015)
Diabetes Care.
, vol.38
, Issue.5
, pp. 808-813
-
-
Steck, A.K.1
-
44
-
-
0028943290
-
Class II antigens and disease susceptibility
-
Nepom GT. Class II antigens and disease susceptibility. Annu Rev Med. 1995;46:17-25.
-
(1995)
Annu Rev Med.
, vol.46
, pp. 17-25
-
-
Nepom, G.T.1
-
45
-
-
84887627529
-
T-lymphocyte recognition of beta cells in type 1 diabetes: Clinical perspectives
-
Boitard C. T-lymphocyte recognition of beta cells in type 1 diabetes: clinical perspectives. Diabetes Metab. 2013;39(6):459-466.
-
(2013)
Diabetes Metab.
, vol.39
, Issue.6
, pp. 459-466
-
-
Boitard, C.1
-
46
-
-
0029619257
-
The Th1/Th2 balance in autoimmunity
-
Charlton B, Lafferty KJ. The Th1/Th2 balance in autoimmunity. Curr Opin Immunol. 1995;7(6):793-798.
-
(1995)
Curr Opin Immunol.
, vol.7
, Issue.6
, pp. 793-798
-
-
Charlton, B.1
Lafferty, K.J.2
-
47
-
-
0031423760
-
The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
-
Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity. 1997;7(6):727-738.
-
(1997)
Immunity.
, vol.7
, Issue.6
, pp. 727-738
-
-
Delovitch, T.L.1
Singh, B.2
-
48
-
-
80755148666
-
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
-
Ferraro A, et al. Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes. 2011;60(11):2903-2913.
-
(2011)
Diabetes.
, vol.60
, Issue.11
, pp. 2903-2913
-
-
Ferraro, A.1
-
49
-
-
64549141552
-
Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes
-
Vija L, et al. Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes. Diabetes Metab. 2009;35(2):85-93.
-
(2009)
Diabetes Metab.
, vol.35
, Issue.2
, pp. 85-93
-
-
Vija, L.1
-
50
-
-
84962052827
-
β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure
-
Skowera A, et al. β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes. 2015;64(3):916-925.
-
(2015)
Diabetes.
, vol.64
, Issue.3
, pp. 916-925
-
-
Skowera, A.1
-
51
-
-
84894542402
-
Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW. 1AR1-iddm rat and humans with type 1 diabetes
-
Jörns A, et al. Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes. Diabetologia. 2014;57(3):512-521.
-
(2014)
Diabetologia.
, vol.57
, Issue.3
, pp. 512-521
-
-
Jörns, A.1
-
52
-
-
84871246684
-
Health implications of high dietary omega-6 polyunsaturated Fatty acids
-
Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C. Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426.
-
(2012)
J Nutr Metab.
, vol.2012
, pp. 539426
-
-
Patterson, E.1
Wall, R.2
Fitzgerald, G.F.3
Ross, R.P.4
Stanton, C.5
-
53
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee K, et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 2010;32(6):743-753.
-
(2010)
Immunity.
, vol.32
, Issue.6
, pp. 743-753
-
-
Lee, K.1
-
54
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009;30(6):832-844.
-
(2009)
Immunity.
, vol.30
, Issue.6
, pp. 832-844
-
-
Delgoffe, G.M.1
-
55
-
-
0026636411
-
Rapamycin prevents the onset of insulindependent diabetes mellitus (IDDM) in NOD mice
-
Baeder WL, Sredy J, Sehgal SN, Chang JY, Adams LM. Rapamycin prevents the onset of insulindependent diabetes mellitus (IDDM) in NOD mice. Clin Exp Immunol. 1992;89(2):174-178.
-
(1992)
Clin Exp Immunol.
, vol.89
, Issue.2
, pp. 174-178
-
-
Baeder, W.L.1
Sredy, J.2
Sehgal, S.N.3
Chang, J.Y.4
Adams, L.M.5
-
56
-
-
0036314243
-
Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
-
Rabinovitch A, Suarez-Pinzon WL, Shapiro AM, Rajotte RV, Power R. Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes. 2002;51(3):638-645.
-
(2002)
Diabetes.
, vol.51
, Issue.3
, pp. 638-645
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
Shapiro, A.M.3
Rajotte, R.V.4
Power, R.5
-
57
-
-
33746368487
-
Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells
-
Battaglia M, et al. Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells. Diabetes. 2006;55(6):1571-1580.
-
(2006)
Diabetes.
, vol.55
, Issue.6
, pp. 1571-1580
-
-
Battaglia, M.1
-
58
-
-
33845379986
-
Rapamycin promotes expansion of functional CD4+ CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
-
Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+ CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol. 2006;177(12):8338-8347.
-
(2006)
J Immunol.
, vol.177
, Issue.12
, pp. 8338-8347
-
-
Battaglia, M.1
Stabilini, A.2
Migliavacca, B.3
Horejs-Hoeck, J.4
Kaupper, T.5
Roncarolo, M.G.6
-
59
-
-
51849122220
-
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+ CD25+FOXP3+ regulatory T-cells
-
Monti P, et al. Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+ CD25+FOXP3+ regulatory T-cells. Diabetes. 2008;57(9):2341-2347.
-
(2008)
Diabetes.
, vol.57
, Issue.9
, pp. 2341-2347
-
-
Monti, P.1
-
60
-
-
84939563193
-
Increased intake of vegetable oil rich in n-6 PUFA enhances allergic symptoms and prevents oral tolerance induction in whey-allergic mice
-
van den Elsen LW, van Esch BC, Dingjan GM, Hofman GA, Garssen J, Willemsen LE. Increased intake of vegetable oil rich in n-6 PUFA enhances allergic symptoms and prevents oral tolerance induction in whey-allergic mice. Br J Nutr. 2015;114(4):577-585.
-
(2015)
Br J Nutr.
, vol.114
, Issue.4
, pp. 577-585
-
-
Van Den Elsen, L.W.1
Van Esch, B.C.2
Dingjan, G.M.3
Hofman, G.A.4
Garssen, J.5
Willemsen, L.E.6
-
61
-
-
84903384866
-
Comparative effects of n-3, n-6 and n-9 unsaturated fatty acid-rich diet consumption on lupus nephritis, autoantibody production and CD4+ T cell-related gene responses in the autoimmune NZBWF1 mouse
-
Pestka JJ, Vines LL, Bates MA, He K, Langohr I. Comparative effects of n-3, n-6 and n-9 unsaturated fatty acid-rich diet consumption on lupus nephritis, autoantibody production and CD4+ T cell-related gene responses in the autoimmune NZBWF1 mouse. PLoS ONE. 2014;9(6):e100255.
-
(2014)
PLoS ONE.
, vol.9
, Issue.6
, pp. e100255
-
-
Pestka, J.J.1
Vines, L.L.2
Bates, M.A.3
He, K.4
Langohr, I.5
-
62
-
-
84880850297
-
Diets rich in n-6 PUFA induce intestinal microbial dysbiosis in aged mice
-
Ghosh S, Molcan E, DeCoffe D, Dai C, Gibson DL. Diets rich in n-6 PUFA induce intestinal microbial dysbiosis in aged mice. Br J Nutr. 2013;110(3):515-523.
-
(2013)
Br J Nutr.
, vol.110
, Issue.3
, pp. 515-523
-
-
Ghosh, S.1
Molcan, E.2
DeCoffe, D.3
Dai, C.4
Gibson, D.L.5
-
63
-
-
84920918399
-
Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine
-
Ueda T, et al. Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine. World J Gastroenterol. 2015;21(1):177-186.
-
(2015)
World J Gastroenterol.
, vol.21
, Issue.1
, pp. 177-186
-
-
Ueda, T.1
-
64
-
-
38749108893
-
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
-
Xu X, et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008;132(2):197-207.
-
(2008)
Cell.
, vol.132
, Issue.2
, pp. 197-207
-
-
Xu, X.1
-
65
-
-
27244437951
-
Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells
-
Minami K, et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci U S A. 2005;102(42):15116-15121.
-
(2005)
Proc Natl Acad Sci U S A.
, vol.102
, Issue.42
, pp. 15116-15121
-
-
Minami, K.1
-
66
-
-
77951611220
-
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
-
Thorel F, et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 2010;464(7292):1149-1154.
-
(2010)
Nature.
, vol.464
, Issue.7292
, pp. 1149-1154
-
-
Thorel, F.1
-
67
-
-
0028149890
-
Insulin-promoter-factor 1 is required for pancreas development in mice
-
Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 1994;371(6498):606-609.
-
(1994)
Nature.
, vol.371
, Issue.6498
, pp. 606-609
-
-
Jonsson, J.1
Carlsson, L.2
Edlund, T.3
Edlund, H.4
-
68
-
-
0030897629
-
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
-
Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature. 1997;386(6623):399-402.
-
(1997)
Nature.
, vol.386
, Issue.6623
, pp. 399-402
-
-
Sosa-Pineda, B.1
Chowdhury, K.2
Torres, M.3
Oliver, G.4
Gruss, P.5
-
69
-
-
58449085511
-
Animal models of human type 1 diabetes
-
von Herrath M, Nepom GT. Animal models of human type 1 diabetes. Nat Immunol. 2009;10(2):129-132.
-
(2009)
Nat Immunol.
, vol.10
, Issue.2
, pp. 129-132
-
-
Von Herrath, M.1
Nepom, G.T.2
-
70
-
-
84964681152
-
A preclinical consortium approach for assessing the efficacy of combined anti-CD3 plus IL-1 blockade in reversing new-onset autoimmune diabetes in NOD mice
-
Gill RG, et al. A preclinical consortium approach for assessing the efficacy of combined anti-CD3 plus IL-1 blockade in reversing new-onset autoimmune diabetes in NOD mice. Diabetes. 2016;65(5):1310-1316.
-
(2016)
Diabetes.
, vol.65
, Issue.5
, pp. 1310-1316
-
-
Gill, R.G.1
-
71
-
-
84894354624
-
Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes
-
Zhang L, et al. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014;111(7):2656-2661.
-
(2014)
Proc Natl Acad Sci U S A.
, vol.111
, Issue.7
, pp. 2656-2661
-
-
Zhang, L.1
-
72
-
-
84907222568
-
Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response
-
Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C. Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response. J Immunol. 2014;193(7):3308-3321.
-
(2014)
J Immunol.
, vol.193
, Issue.7
, pp. 3308-3321
-
-
Karumuthil-Melethil, S.1
Gudi, R.2
Johnson, B.M.3
Perez, N.4
Vasu, C.5
-
73
-
-
84555188737
-
Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: Evidence of improved immune regulation
-
Ablamunits V, et al. Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation. Diabetes. 2012;61(1):145-154.
-
(2012)
Diabetes.
, vol.61
, Issue.1
, pp. 145-154
-
-
Ablamunits, V.1
-
74
-
-
84971674653
-
-
National Research Council (US) Subcommittee on Laboratory Animal Nutrition. Washington (DC): National Academies Press (US)
-
National Research Council (US) Subcommittee on Laboratory Animal Nutrition. Nutrient Requirements of Laboratory Animals: Fourth Revised Edition, 1995. Washington (DC): National Academies Press (US); 1995.
-
(1995)
Nutrient Requirements of Laboratory Animals: Fourth Revised Edition, 1995
-
-
-
75
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37(8):911-917.
-
(1959)
Can J Biochem Physiol.
, vol.37
, Issue.8
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
76
-
-
34250666701
-
Production and purification of lentiviral vectors
-
Tiscornia G, Singer O, Verma IM. Production and purification of lentiviral vectors. Nat Protoc. 2006;1(1):241-245.
-
(2006)
Nat Protoc.
, vol.1
, Issue.1
, pp. 241-245
-
-
Tiscornia, G.1
Singer, O.2
Verma, I.M.3
-
77
-
-
84899523999
-
Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis
-
Li L, et al. Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis. PLoS ONE. 2014;9(4):e94092.
-
(2014)
PLoS ONE.
, vol.9
, Issue.4
, pp. e94092
-
-
Li, L.1
|