Kallikrein-Kinin system mediated inflammation in Alzheimer's disease In Vivo

Current Alzheimer Research

Volumn 8, Issue 1, 2011, Pages 59-66

  Viel, T A ^a   Buck, H S ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

Author keywords

Alzheimer's disease; B1 receptor; B2 receptor; In vivo; Kallikrein; Kinin; Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN; BRADYKININ; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR;

ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; COGNITIVE DEFECT; HUMAN; IN VIVO STUDY; KALLIKREIN KININ SYSTEM; MEMORY; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ALZHEIMER DISEASE; ANIMALS; HUMANS; INFLAMMATION; KALLIKREINS; KININS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 79951720003     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720511794604570     Document Type: Article

References (80)

1. Baumgarten CR, Togias AG, Naclerio RM, Lichtenstein LM, Norman PS and Proud D. Influx of kininogens into nasal secretions after antigen challenge of allergic individuals. J Clin Invest 76(1): 191-197 (1985).
2. Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA and Campos MM. Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes. Br J Pharmacol 143(7): 803-818 (2004).
3. Couture R and Lindsey C J. Brain kallikrein-kinin system: From receptors to neuronal pathways and physiological functions. In Handbook of Chemical Neuroanatomy, Peptide Receptors (Ed.Quirion R., Björklund A. and Hökfelt T.), Elsevier Science B. V. 16: p. 241-300 (2000).
4. Schulze-Topphoff U, Prat A, Bader M, Zipp F and Aktas O. Roles of the kallikrein/kinin system in the adaptive immune system. Intern Immunopharmacol 8: 155-160 (2008).
5. Bhoola KD, Figueroa CD and Worthy K. Bioregulation of kinins: kallikreins, kininogens and kininases. Pharmacol Rev 44: 1-80 (1992).
6. Regoli D and Barabe J. Pharmacology of bradykinin and related kinins. Pharmacol Rev 32: 1-46 (1980).
7. Maeda H, Wu J, Okamoto T, Maruo K and Akaike T. Kallikrein- Kinin in infection and cancer. Immunopharmacol 43(2-3): 115-128 (1999).
8. Regoli D, Nsa Allogho S, Rizzi A and Gobeil FJ. Bradykinin receptors and their antagonists. Eur J Pharmacol 348(1): 1-10 (1998).
9. Bascands JL, Pecher C, Rouaud S, Emond C, Tack JL, Bastie MJ, et al. Evidence for existence of two distinct bradykinin receptors on rat mesangial cells. Am J Physiol 264: F548-F556 (1993).
10. Smith JAM, Webb C, Holford J, and Burgess GM. Signal transduction pathways for B1 and B2 bradykinin receptors in bovine pulmonary artery endothelial cells. Mol Pharmacol 47: 525-34 (1995).
11. Mathis SA, Criscimagna NL and Leeb-Lundberg LMF. B1 and B2 kinin receptors mediate distinct patterns of intracellular Ca2+ signaling in single cultured vascular smooth muscle cells. Mol Pharmacol 50:128-39 (1996).
12. Delmas P, Wanaverbecq N, Abogadie FC, Mistry M, Brown DA. Signaling microdomains define the specificity of receptor-mediated InsP3 pathways in neurons. Neuron 14: 209-20 (2002).
13. Steranka LR, Manning DC, DeHaas CJ, Ferkany JW, Borosky SA, Connor JR, et al. Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions. Proc Natl Acad Sci USA 85: 3245-9 (1988).
14. Leeb-Lundberg LMF, Marceau F, Ller-Esterl WM, Pettibone DJ and Zuraw BL. International union of pharmacology. XLV.Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 57: 27-77 (2005).
15. Marceau F, Hess JF and Bachvarov DR. The B1 receptors for kinins. Pharmacol Rev 50(3): 357-386 (1998).
16. Prat A, Weinrib L, Becher B, Poirier J, Duquette P, Couture R and Antel JP. Bradykinin B1 receptor expression and function on T lymphocytes in active multiple sclerosis. Neurology 53: 2087-92 (1999).
17. Prat A, Biernacki K, Pouly S, Nalbantoglu J, Couture R, Antel JP. et al. Kinin B1 receptor expression and function on human brain endothelial cells. J Neuropat Exp Neurol 59: 896-906 (2000).
18. Li Z, Tyor WR, Xu J, Chao J and Hogan EL. Immunohistochemical localization of kininogen in rat spinal cord and brain. Exp Neurol 159(2): 528-537 (1999).
19. Raidoo DM and Bhoola KD. Pathophysiology of the Kalikrein_ Kinin system in mammalian nervous tissue. Pharmacol Ther 79(2): 105-127 (1998).
20. Mayhan WG. Regulation of blood-brain barrier permeability. Microcirculation 8(2):89-104 (2001).
21. Noda M, Sasaki K, Ifuku M and Wada K. Multifunctional effects of bradykinin on glial cells in relation to potential antiinflammatory effects. Neurochem Int 51: 185-191 (2007a).
22. Okada Y, Tuchiya Y, Yagyu M, Kozawa S and Kariya K. Synthesis of bradykinin fragments and their effect on pentobarbital sleeping time in mouse. Neuropharmacol 16: 381-383 (1977).
23. Kariya K and Yamauchi A. Effects of intraventricular injection of bradykinin on the EEG and the blood pressure in conscious rats. Neuropharmacol 20: 1221-1224 (1981).
24. Hoffman WE and Schimid PG. Separation of pressor and antidiuretic effects of intraventricular bradykinin. Neuropharmacology 17: 999-1002 (1978).
25. Fior DR, Martins DTO and Lindsey CJ. Localization of central pressor action of bradykinin in medulla oblongata. Am J Physiol 265: H1000-H1006 (1993).
26. Lindsey CJ, Buck HS, Fior-Chadi DR and Lapa RCRS. Pressor effect mediated by bradykinin in the paratrigeminal nucleus of the rat. J Physiol 502.1: 119-129 (1997).
27. Cloutier F, de Sousa Buck H, Ongali B and Couture R. Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats. Br J Pharmacol 135(7): 1641-1654 (2002).
28. Wang Q and Wang J. Injection of bradykinin or cyclosporine A to hippocampus induces Alzheimer-like phosphorylation of Tau and abnormal behavior in rats. Chin Med J 115(6): 884-887 (2002).
29. Lewis RE, Childers SR and Phillips MI. [125I]Tyr-bradykinin binding in primary rat brain cultures. Brain Res 346: 263-272 (1985).
30. Cholewinski AJ, Stevens G, McDermott AM and Wilkin GP. Identification of B2 bradykinin binding sites on cultured cortical astrocytes. J Neurochem 57: 1456-1458 (1991).
31. Kozlowski MR, Rosser MP, Hall E. Identification of 3H-bradykinin binding sites in PC-12 cells and brain. Neuropeptides 12(4): 207-211 (1988).
32. Fujiwara Y, Mantione CR and Yamamura HI. Identification of B2 bradykinin binding sites in guinea-pig brain. Eur J Pharmacol 147: 487-488 (1998).
33. Sharif NA and Whiting RL. Identification of B2-bradykinin receptors in guinea pig brain regions, spinal cord and peripheral tissues. Neurochem Int 18: 89-96 (1991).
34. Ma JX, Wang DZ, Ward DC, Chen L, Dessai T, Chao J and Chao L. Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. Genomics 23: 362-369 (1994a).
35. Ma JX, Wang DZ, Chao L and Chao J. Cloning, sequence analysis and expression of the gene encoding the mouse bradykinin B2 receptor. Gene 149: 283-288 (1994b).
36. Raidoo DM, Ramchurren N, Naidoo Y, Naidoo S, Müller-Esterl W and Bhoola KD. Visualisation of bradykinin B2 receptors on human brain neurons. Immunopharmacology 33: 104-107 (1996).
37. Lopes P, Kar S, Tousignant C, Regoli D, Quirion R and Couture R. Autoradiographic localization of [125I-Tyr8]-bradykinin receptor binding sites in the guinea pig spinal cord. Synapse 15: 48-57 (1993).
38. Murone C, Paxinos G, McKinley MJ, Oldfield BJ, Müller-Esterl W, Mendelsohn FAO, et al. Distribution of bradykinin B2 receptors in sheep brain and spinal cord visualized by in vitro autoradiography. J Comp Neurol 381: 203-218 (1997).
39. Viel TA, Lima Caetano A, Nasello AG, Lancelotti CL, Nunes VA, Araujo MS, et al. Increases of kinin B1 and B2 receptors binding sites after brain infusion of amyloid-beta 1-40 peptide in rats. Neurobiol Aging 29(12): 1805-1814 (2008).
40. de Sousa Buck H, Ongali B, Thibault G, Lindsey CJ and Couture R. Autoradiographic detection of kinin receptors in the human medulla of control, hypertensive and diabetic donors. Can J Physiol Pharmacol 80(4): 249-257 (2002).
41. Chai KX, Ni A, Wang D, Ward DC, Chao J and Chao L. Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1. Genomics 31: 51- 57 (1996).
42. Wotherspoon G and Winter J. Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system. Neurosci Letters 294: 175-178 (2000).
43. Raidoo DM and Bhoola KD. Kinin receptors on human neurones. J Neuroimmunol 77: 39-44 (1997).
44. Campos MM, Ongali B, De Souza Buck H, Schanstra JP, Girolami JP, Chabot JG, et al. Expression and distribution of kinin B1 receptor in the rat brain and alterations induced by diabetes in the model of streptozotocin.Synapse 57(1): 29-37 (2005).
45. Jackson CM and Nemerson Y. Blood coagulation. Annu Rev Biochem, 49: 765-811 (1980).
46. Silverberg M, Dunn JT, Garen L and Kaplan AP. Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate. J Biol Chem 255(15): 7281-7286 (1980).
47. Huang HM, Lin TA, Sun GY, Gibson GE. Increased inositol 1,4,5- trisphosphateaccumulation correlates with an up-regulation of bradykinin receptors in Alzheimer's disease. J Neurochem;64(2): 761-766 (1995).
48. Bergamaschini L, Donarini C, Gobbo G, Parnetti L and Gallai V. Activation of complement and contact system in Alzheimer's disease. Mech Ageing Dev 122: 1971-1983 (2001).
49. Joseph K, Shibayama Y, Nakazawa Y, Peerschke EI, Ghebrehiwet B and Kaplan AP. Interaction of factor XII and high molecular weight kininogen with cytokeratin 1 and gC1qR of vascular endothelial cells and with aggregated Abeta protein of Alzheimer's disease. Immunopharmacol 43: 203-210 (1999).
50. Nitsch RM, Kim C and Growdon J H. Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease. Neurochem Res 23(5): 807-814 (1998).
51. Racchi M, Ianna P, Binetti G, Trabucchi M and GovonI S. Bradykinin-induced amyloid precursor protein secretion: a protein kinase C-independent mechanism that is not altered in fibroblasts from patients with sporadic Alzheimer's disease. Biochem J 330: 1271-1275 (1998).
52. Khan TK and Alkon DL. An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin. PNAS 103(35): 13203-13207 (2006).
53. Jong YJ, Dalemar LR, Seehra K and Baenziger NL. Bradykinin receptor modulation in cellular models of aging and Alzheimer's disease. Int Immunopharmacol 2(13-14): 1833-1840 (2002).
54. Iores-Marçal LM, Viel TA, Buck HS, Nunes VA, Gozzo AJ, Cruz-Silva I, et al. Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease. Peptides. 27(12): 3363-3369 (2006).
55. Griffiths EC. Clinical applications of thyrotropin-releasing hormone. Clin Sci (Lond) 73 (5): 449-457 (1987).
56. Huston JP and Hasenöhrl RU. The role of neuropeptides in learning: focus on the neurokinin substance P. Behav Brain Res 66: 117- 127 (1995).
57. Aoyagi T, Wada T, Nagai M, Kojima F, Harada S, Takeuchi T, et al. Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease. Experientia 46: 94-97 (1990).
58. Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, et al. Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience 151(3): 631-643 (2008).
59. McGeer EG and McGeer PL. Inflammatory processes in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 27: 741-749 (2003).
60. Salminen A, Ojala J, Kauppinen A, Kaarniranta K and Suuronen T. Inflammation in Alzheimer's disease: Amyloid-b oligomers trigger innate immunity defense via pattern recognition receptors. Prog Neurobiol 87: 181-194 (2009).
61. Passos GF, Fernandez ES, Campos MM, Araujo JGVC, Pesquero JL, Souza GEP, et al. Kinin B1 receptor upregulation after lipopolysaccharide administration: role of proinflammatory cytokines and neutrophil influx. J Immunol 172:1839-1847 (2004).
62. Noda M, Kariura Y, Amanoa T, Managoa Y, Nishikawab K, Aokib S, Kinin B1 Expression and function of bradykinin receptors in microglia. Life Sci 72: 1573-1581 (2003).
63. Levant A, Levy E, Argaman M and Fleisher-Berkovich S. Kinins and neuroinflammation: Dual effect on prostaglandin synthesis. European J Pharmacol 546: 197-200 (2006).
64. 9-bradykinin. J Neuroinflammation 6:11 (2009).
65. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19(8): 312-318 (1996).
66. Dray A. Kinins and their receptors in hyperalgesia. Can J Physiol Pharm 75: 704-712 (1997).
67. Noda M, Kariura Y, Pannasch U, Nishikawa K, Wang L, Seike T, et al. Neuroprotective role of bradykinin because of the attenuation of proinflammatory cytokine release from activated microglia. J Neurochem 101: 397-410 (2007b).
68. Amaral FA, Lemos MTR, Dong KE, Bittencourt MFQP, Caetano AL, Pesquero JB, et al. Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-β1-40 (Aβ) peptide in mice. Neuropeptides 44: 93-97 (2010).
69. 2+ exchanger. J Neurosc 27(48): 13065-13073 (2007).
70. Banati RB, Rothe G, Valet G and Kreutzberg GW. Detection of lysosomal cysteine proteinases in microglia: flow cytometric meas urement and histochemical localization of cathepsin B and L. Glia 7(2): 183-191 (1993).
71. McGeer EG and McGeer PL. Abeta immunotherapy and other means to remove amyloid. Curr Drug Targets CNS Neurol Disord 4(5):569-573 (2005).
72. Schanstra JP, Bataille E, Marin Castano ME, Barascud Y, Hirtz C, Pesquero JB, et al. The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-KB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts. J Clin Investig 101: 2080-2091 (1998).
73. Phagoo SB, Poole S and Leeb-Lundberg LMF. Autoregulation of bradykinin receptors: agonists in the presence of interleukin-1 shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts. Mol Pharmacol 56:325-333 (1999).
74. Zhang X, Tan F, Zhang Y, Skidgel RA. Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists. J Biol Chem 283(12): 7994-8004 (2008).
75. Marin Castaño ME, Schanstra JP, Hirtz C, Pesquero JB, Pecher C, Girolami JP, et al. B2 kinin receptor upregulation by cAMP is associated with BK-induced PGE2 production in rat mesangial cells. Am J Physiol 274(3 Pt 2): F532-540 (1998).
76. Lemos MTR, Amaral FA, Bittencourt MFQP, Caetano AL, Dong KE, Pesquero JB, et al. Role of kinin B1 and B2 receptors on memory consolidation during aging process of mice. Neuropeptides 44: 163-168 (2010).
77. Cloutier F, Ongali B, Campos MM, Thibault G, Neugebauer W and Couture R. Correlation between brain bradykinin receptor binding sites and cardiovascular function in young and adult spontaneously hypertensive rats. Br J Pharmacol 142(2): 285-296 (2004).
78. Braak H and Braak E. Neuropathological stageing of Alzheimerrelated changes. Acta Neuropathol 82(4): 239-259 (1991).
79. Gómez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH and Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 16(14): 4491- 500 (1996).
80. de Leon MJ, Convit A, Wolf OT, Tarshish CY, DeSanti S, Rusinek H, Tsui W, et al. Prediction of cognitive decline in normal elderly subjects with 2- [(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET). Proc Natl Acad Sci USA 11: 98(19): 10966-10971 (2001).