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Volumn 141, Issue , 2016, Pages S59-S61

A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease

Author keywords

Alzheimer's disease; beta amyloid; contact activation system; factor XII; fibrin(ogen)

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 12; BRADYKININ; COMPLEMENT COMPONENT C1S INHIBITOR; ENZYME PRECURSOR; FIBRIN; FIBRINOGEN; HIGH MOLECULAR WEIGHT KININOGEN; PLASMA KALLIKREIN; PREKALLIKREIN; THROMBIN;

EID: 84989937227     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/S0049-3848(16)30367-X     Document Type: Article
Times cited : (30)

References (45)
  • 2
    • 0033202045 scopus 로고    scopus 로고
    • Overlap between pathology of Alzheimer disease and vascular dementia
    • 2 Kalaria, RN, Ballard, C, Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer disease and associated disorders 13:Suppl 3 (1999), S115–S123.
    • (1999) Alzheimer disease and associated disorders , vol.13 , pp. S115-S123
    • Kalaria, R.N.1    Ballard, C.2
  • 3
    • 0034603512 scopus 로고    scopus 로고
    • The role of cerebral ischemia in Alzheimer's disease
    • 3 Kalaria, RN, The role of cerebral ischemia in Alzheimer's disease. Neurobiology of aging 21 (2000), 321–330.
    • (2000) Neurobiology of aging , vol.21 , pp. 321-330
    • Kalaria, R.N.1
  • 4
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • 4 Farkas, E, Luiten, PG, Cerebral microvascular pathology in aging and Alzheimer's disease. Progress in neurobiology 64 (2001), 575–611.
    • (2001) Progress in neurobiology , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 8
    • 84876238102 scopus 로고    scopus 로고
    • Alzheimer disease and risk of stroke: a population-based cohort study
    • 8 Chi, NF, Chien, LN, Ku, HL, Hu, CJ, Chiou, HY, Alzheimer disease and risk of stroke: a population-based cohort study. Neurology 80 (2013), 705–711.
    • (2013) Neurology , vol.80 , pp. 705-711
    • Chi, N.F.1    Chien, L.N.2    Ku, H.L.3    Hu, C.J.4    Chiou, H.Y.5
  • 9
    • 77953679700 scopus 로고    scopus 로고
    • Fibrinogen and beta-Amyloid Association Alters Thrombosis and Fibrinolysis: a Possible Contributing Factor to Alzheimer's Disease
    • 9 Cortes-Canteli, M, Paul, J, Norris, EH, Bronstein, R, Ahn, HJ, Zamolodchikov, D, et al. Fibrinogen and beta-Amyloid Association Alters Thrombosis and Fibrinolysis: a Possible Contributing Factor to Alzheimer's Disease. Neuron 66 (2010), 695–709.
    • (2010) Neuron , vol.66 , pp. 695-709
    • Cortes-Canteli, M.1    Paul, J.2    Norris, E.H.3    Bronstein, R.4    Ahn, H.J.5    Zamolodchikov, D.6
  • 10
    • 84903128278 scopus 로고    scopus 로고
    • Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease
    • 10 Jarre, A, Gowert, NS, Donner, L, Munzer, P, Klier, M, Borst, O, et al. Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease. Cellular signalling 26 (2014), 2040–2050.
    • (2014) Cellular signalling , vol.26 , pp. 2040-2050
    • Jarre, A.1    Gowert, N.S.2    Donner, L.3    Munzer, P.4    Klier, M.5    Borst, O.6
  • 11
    • 13244252248 scopus 로고    scopus 로고
    • Dementia in subjects with atrial fibrillation: hemostatic function and the role of anticoagulation
    • 11 Barber, M, Tait, RC, Scott, J, Rumley, A, Lowe, GD, Stott, DJ, Dementia in subjects with atrial fibrillation: hemostatic function and the role of anticoagulation. J Thromb Haemost 2 (2004), 1873–1878.
    • (2004) J Thromb Haemost , vol.2 , pp. 1873-1878
    • Barber, M.1    Tait, R.C.2    Scott, J.3    Rumley, A.4    Lowe, G.D.5    Stott, D.J.6
  • 13
    • 0018125505 scopus 로고
    • Senile-presenile dementia: follow-up data on an effective psychotherapy-anticoagulant regimen
    • 13 Walsh, AC, Walsh, BH, Melaney, C, Senile-presenile dementia: follow-up data on an effective psychotherapy-anticoagulant regimen. J Am Geriatr Soc 26 (1978), 467–470.
    • (1978) J Am Geriatr Soc , vol.26 , pp. 467-470
    • Walsh, A.C.1    Walsh, B.H.2    Melaney, C.3
  • 14
    • 0029820350 scopus 로고    scopus 로고
    • Anticoagulant therapy for Alzheimer's disease
    • 14 Walsh, AC, Anticoagulant therapy for Alzheimer's disease. J Neuropsychiatry Clin Neurosci 8 (1996), 361–362.
    • (1996) J Neuropsychiatry Clin Neurosci , vol.8 , pp. 361-362
    • Walsh, A.C.1
  • 15
    • 2442483898 scopus 로고    scopus 로고
    • Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease
    • 15 Bergamaschini, L, Rossi, E, Storini, C, Pizzimenti, S, Distaso, M, Perego, C, et al. Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease. J Neurosci 24 (2004), 4181–4186.
    • (2004) J Neurosci , vol.24 , pp. 4181-4186
    • Bergamaschini, L.1    Rossi, E.2    Storini, C.3    Pizzimenti, S.4    Distaso, M.5    Perego, C.6
  • 16
    • 77955844393 scopus 로고    scopus 로고
    • Enoxaparin treatment administered at both early and late stages of amyloid beta deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Abeta levels
    • 16 Timmer, NM, van Dijk, L, van der Zee, CE, Kiliaan, A, de Waal, RM, Verbeek, MM, Enoxaparin treatment administered at both early and late stages of amyloid beta deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Abeta levels. Neurobiol Dis 40 (2010), 340–347.
    • (2010) Neurobiol Dis , vol.40 , pp. 340-347
    • Timmer, N.M.1    van Dijk, L.2    van der Zee, C.E.3    Kiliaan, A.4    de Waal, R.M.5    Verbeek, M.M.6
  • 17
    • 84875655895 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature
    • 17 Wyss-Coray, T, Rogers, J, Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med, 2, 2012, a006346.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a006346
    • Wyss-Coray, T.1    Rogers, J.2
  • 18
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    • 18 Wyss-Coray, T, Inflammation in Alzheimer disease: driving force, bystander or beneficial response?. Nat Med 12 (2006), 1005–1015.
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 19
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • 19 Hardy, J, Selkoe, DJ, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002), 353–356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 20
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
    • 20 Tanzi, RE, Bertram, L, Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120 (2005), 545–555.
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 22
    • 84859569047 scopus 로고    scopus 로고
    • Abeta delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin
    • 22 Zamolodchikov, D, Strickland, S, Abeta delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin. Blood 119 (2012), 3342–3351.
    • (2012) Blood , vol.119 , pp. 3342-3351
    • Zamolodchikov, D.1    Strickland, S.2
  • 23
    • 84881181605 scopus 로고    scopus 로고
    • The APOE varepsilon4/varepsilon4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients
    • 23 Hultman, K, Strickland, S, Norris, EH, The APOE varepsilon4/varepsilon4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. J Cereb Blood Flow Metab 33 (2013), 1251–1258.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1251-1258
    • Hultman, K.1    Strickland, S.2    Norris, E.H.3
  • 24
    • 84856667645 scopus 로고    scopus 로고
    • Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAbeta mice
    • 24 Klohs, J, Baltes, C, Princz-Kranz, F, Ratering, D, Nitsch, RM, Knuesel, I, et al. Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAbeta mice. J Neurosci 32 (2012), 1705–1713.
    • (2012) J Neurosci , vol.32 , pp. 1705-1713
    • Klohs, J.1    Baltes, C.2    Princz-Kranz, F.3    Ratering, D.4    Nitsch, R.M.5    Knuesel, I.6
  • 26
    • 84859715302 scopus 로고    scopus 로고
    • Fibrinogen as a key regulator of inflammation in disease
    • 26 Davalos, D, Akassoglou, K, Fibrinogen as a key regulator of inflammation in disease. Sem Immunopathol 34 (2012), 43–62.
    • (2012) Sem Immunopathol , vol.34 , pp. 43-62
    • Davalos, D.1    Akassoglou, K.2
  • 27
    • 84880293052 scopus 로고    scopus 로고
    • Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain
    • 27 Nishimura, N, Schaffer, CB, Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain. Stroke 44 (2013), S90–S92.
    • (2013) Stroke , vol.44 , pp. S90-S92
    • Nishimura, N.1    Schaffer, C.B.2
  • 29
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • 29 Paul, J, Strickland, S, Melchor, JP, Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 204 (2007), 1999–2008.
    • (2007) J Exp Med , vol.204 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 30
    • 84901801735 scopus 로고    scopus 로고
    • A novel Abeta-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice
    • 30 Ahn, HJ, Glickman, JF, Poon, KL, Zamolodchikov, D, Jno-Charles, OC, Norris, EH, et al. A novel Abeta-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. J Exp Med 211 (2014), 1049–1062.
    • (2014) J Exp Med , vol.211 , pp. 1049-1062
    • Ahn, H.J.1    Glickman, J.F.2    Poon, K.L.3    Zamolodchikov, D.4    Jno-Charles, O.C.5    Norris, E.H.6
  • 31
    • 84862700955 scopus 로고    scopus 로고
    • The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease
    • 31 Pimentel-Coelho, PM, Rivest, S, The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur J Neurosci 35 (2012), 1917–1937.
    • (2012) Eur J Neurosci , vol.35 , pp. 1917-1937
    • Pimentel-Coelho, P.M.1    Rivest, S.2
  • 32
    • 84904654930 scopus 로고    scopus 로고
    • Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy
    • 32 Takeda, S, Sato, N, Morishita, R, Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front Aging Neurosci, 6, 2014, 171.
    • (2014) Front Aging Neurosci , vol.6 , pp. 171
    • Takeda, S.1    Sato, N.2    Morishita, R.3
  • 33
    • 33947363967 scopus 로고    scopus 로고
    • The fibrin-derived gamma377–395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    • 33 Adams, RA, Bauer, J, Flick, MJ, Sikorski, SL, Nuriel, T, Lassmann, H, et al. The fibrin-derived gamma377–395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med 204 (2007), 571–582.
    • (2007) J Exp Med , vol.204 , pp. 571-582
    • Adams, R.A.1    Bauer, J.2    Flick, M.J.3    Sikorski, S.L.4    Nuriel, T.5    Lassmann, H.6
  • 34
    • 34547415988 scopus 로고    scopus 로고
    • Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor
    • 34 Schachtrup, C, Lu, P, Jones, LL, Lee, JK, Lu, J, Sachs, BD, et al. Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci U S A 104 (2007), 11814–11819.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 11814-11819
    • Schachtrup, C.1    Lu, P.2    Jones, L.L.3    Lee, J.K.4    Lu, J.5    Sachs, B.D.6
  • 35
    • 77951664911 scopus 로고    scopus 로고
    • Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage
    • 35 Schachtrup, C, Ryu, JK, Helmrick, MJ, Vagena, E, Galanakis, DK, Degen, JL, et al. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci 30 (2010), 5843–5854.
    • (2010) J Neurosci , vol.30 , pp. 5843-5854
    • Schachtrup, C.1    Ryu, J.K.2    Helmrick, M.J.3    Vagena, E.4    Galanakis, D.K.5    Degen, J.L.6
  • 37
  • 38
    • 51349160073 scopus 로고    scopus 로고
    • Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation
    • 38 Maas, C, Govers-Riemslag, JW, Bouma, B, Schiks, B, Hazenberg, BP, Lokhorst, HM, et al. Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation. J Clin Invest 118 (2008), 3208–3218.
    • (2008) J Clin Invest , vol.118 , pp. 3208-3218
    • Maas, C.1    Govers-Riemslag, J.W.2    Bouma, B.3    Schiks, B.4    Hazenberg, B.P.5    Lokhorst, H.M.6
  • 40
    • 84961290482 scopus 로고    scopus 로고
    • Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma
    • 40 Zamolodchikov, D, Chen, ZL, Conti, BA, Renne, T, Strickland, S, Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma. Proc Natl Acad Sci U S A 112 (2015), 4068–4073.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 4068-4073
    • Zamolodchikov, D.1    Chen, Z.L.2    Conti, B.A.3    Renne, T.4    Strickland, S.5
  • 41
    • 84870057666 scopus 로고    scopus 로고
    • Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement
    • 41 Musiek, ES, Holtzman, DM, Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Curr Opin Neurol 25 (2012), 715–720.
    • (2012) Curr Opin Neurol , vol.25 , pp. 715-720
    • Musiek, E.S.1    Holtzman, D.M.2
  • 42
    • 84989849258 scopus 로고    scopus 로고
    • The Alzheimer's disease peptide Abeta promotes thrombin generation through activation of coagulation factor XII
    • [Epub ahead of print].
    • 42 Zamolodchikov, D, Renne, T, Strickland, S, The Alzheimer's disease peptide Abeta promotes thrombin generation through activation of coagulation factor XII. J Thromb Haemost, 2015 [Epub ahead of print].
    • (2015) J Thromb Haemost
    • Zamolodchikov, D.1    Renne, T.2    Strickland, S.3
  • 43
    • 42449142396 scopus 로고    scopus 로고
    • Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma
    • 43 Cutler, P, Akuffo, EL, Bodnar, WM, Briggs, DM, Davis, JB, Debouck, CM, et al. Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma. Proteomics Clinical applications 2 (2008), 467–477.
    • (2008) Proteomics Clinical applications , vol.2 , pp. 467-477
    • Cutler, P.1    Akuffo, E.L.2    Bodnar, W.M.3    Briggs, D.M.4    Davis, J.B.5    Debouck, C.M.6
  • 44
    • 84919915106 scopus 로고    scopus 로고
    • Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts
    • 44 Muenchhoff, J, Poljak, A, Song, F, Raftery, M, Brodaty, H, Duncan, M, et al. Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts. J Alzheimers Dis 43 (2015), 1355–1373.
    • (2015) J Alzheimers Dis , vol.43 , pp. 1355-1373
    • Muenchhoff, J.1    Poljak, A.2    Song, F.3    Raftery, M.4    Brodaty, H.5    Duncan, M.6
  • 45
    • 38949099750 scopus 로고    scopus 로고
    • Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis
    • 45 Merkulov, S, Zhang, WM, Komar, AA, Schmaier, AH, Barnes, E, Zhou, Y, et al. Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood 111 (2008), 1274–1281.
    • (2008) Blood , vol.111 , pp. 1274-1281
    • Merkulov, S.1    Zhang, W.M.2    Komar, A.A.3    Schmaier, A.H.4    Barnes, E.5    Zhou, Y.6


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