Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease

Behavioural Brain Research

Volumn 222, Issue 1, 2011, Pages 169-175

  Walker, J M ^a   Fowler, S W ^a   Miller, D K ^a   Sun, A Y ^b   Weisman, G A ^a,b   Wood, W G ^c   Sun, G Y ^b   Simonyi, A ^b   Schachtman, T R ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Alzheimer's disease; Barnes maze; Open field; Spatial learning and memory; TgCRND8; Touch escape

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

AGE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ERROR; ESCAPE BEHAVIOR; FEMALE; HABITUATION; IRRITABILITY; LATENT PERIOD; LEARNING; LOCOMOTION; MAZE TEST; MEMORY DISORDER; MENTAL PERFORMANCE; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SPATIAL LEARNING; WILD TYPE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; ESCAPE REACTION; EXPLORATORY BEHAVIOR; FEMALE; HUMANS; LEARNING DISORDERS; LOCOMOTION; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PHYSICAL STIMULATION; REACTION TIME; RETENTION (PSYCHOLOGY); SPACE PERCEPTION; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 79955085667     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.03.049     Document Type: Article

References (47)

1. Ambrée O., Touma C., Görtz N., Keyvani K., Paulus W., Palme R., et al. Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice. Neurobiol Aging 2006, 27:955-964.
2. Ambrée O., Richter H., Sachser N., Lewejohann L., Dere E. Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer's disease. Neurobiol Aging 2009, 30:1192-1204.
3. Bartus R.T. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 2000, 163:495-529.
4. Bellucci A., Luccarini I., Scali C., Prosperi C., Giovannini M.G., Pepeu G., et al. Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice. Neurobiol Dis 2006, 23:260-272.
5. Belluci A., Rosi M.C., Grossi C., Fiorentini A., Luccarini I., Casamenti F. Abnormal processing of tau in the brain of aged TgCRND8 mice. Neurobiol Dis 2007, 27:328-338.
6. Chishti M.A., Yang D.S., Janus C., Phinney A.L., Horne P., Pearson J. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 2001, 276:21562-21570.
7. Corder E.H., Ghebremedhin E., Taylor M.G., Thal D.R., Ohm T.G., Braak H. The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism. Ann NY Acad Sci 2004, 1019:24-28.
8. Cummings J.L. Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis. Neurobiol Aging 2000, 21:845-861.
9. Dudal S., Krzywkowski P., Paquette J., Morissette C., Lacombe D., Tremblay P., et al. Inflammation occurs early during the Aβ deposition process in TgCRND8 mice. Neurobiol Aging 2004, 25:861-871.
10. Dumont M., Strazielle C., Staufenbiel M., Lalonde R. Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation. Brain Res 2004, 1024:113-121.
11. Ferri C.P., Prince M., Brayne C., Brodaty H., Fratiglioni L., Ganguli M., et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005, 366:2112-2117.
12. Filali M., Lalonde R., Rivest S. Cognitive and non-cognitive behaviors in an APPswe/PS1 biogenic model of Alzheimer's disease. Genes Brain Behav 2009, 8:143-148.
13. Finkel S.I. Behavioral and psychologic symptoms of dementia. Clin Geriatr Med 2003, 19:799-824.
14. Francis B.M., Kim J., Barakat M.E., Fraenkl S., Yucel Y.H., Peng S., et al. Object recognition memory and BDNF expression are reduced in young TgCRND8 mice. Neurobiol Aging 2010, 10.1016/j.neurobiolaging.2010.04.003.
15. Giovannini M.G., Cerbai F., Bellucci A., Melani C., Grossi C., Bartolozzi C., et al. Differential activation of mitogen-activated protein kinase signaling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease. Neuroscience 2008, 153:618-633.
16. Görtz N., Lewejohann L., Tomm M., Ambrée O., Keyvani K., Paulus W., et al. Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behav Brain Res 2008, 191:43-48.
17. Harrison F.E., Reiserer R.S., Tomarken A.J., McDonald M.P. Spatial and nonspatial escape strategies in the Barnes maze. Learn Mem 2006, 13:809-819.
18. Harrison F.E., Hosseini A.H., McDonald M.P. Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behav Brain Res 2009, 198:247-251.
19. Huitron-Resendiz S., Sanchez-Alverez M., Gallegos R., Berg G., Crawford E., Giacchino J.L., et al. Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice. Brain Res 2002, 928:126-137.
20. Hyde L.A., Kazdoba T.M., Grilli M., Lozza G., Brusa R., Zhang Q. Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice. Behav Brain Res 2005, 160:344-355.
21. Janus C. Search strategies used by APP transgenic mice during navigation in the Morris-water maze. Learn Mem 2004, 11:457-474.
22. Janus C., Welzl H., Hanna A., Lovasic L., Lane N., St.George-Hyslop P., et al. Impaired conditioned taste aversion learning in APP transgenic mice. Neurobiol Aging 2004, 25:1213-1219.
23. Janus C., Westaway D. Transgenic mouse models of Alzheimer's disease. Physiol Behav 2001, 73:873-886.
24. Krantic S.M., Bonnet M., Yu W., Chanut A., McLaurin J., Quirion A. Different mechanisms mediate cell death in vulnerable brain areas of TgCRND8 mouse model of Alzheimer's disease. Program No. 48.14/I23. 2010 Neuroscience Meeting Planner 2010, Society for Neuroscience, San Diego, CA, [online].
25. Lanari A., Amenta F., Silvestrelli G., Tomassoni D., Parnetti L. Neurotransmitter deficits in behavioural and psychology symptoms of Alzheimer's disease. Mech Ageing Dev 2006, 127:158-165.
26. Laske C., Stransky E., Leyhe T., Eschweiler G.W., Wittorf A., Rizhartz E., et al. Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm 2006, 113:1217-1224.
27. Lewejohann L., Reefmann N., Widmann P., Ambrée O., Herring A., Keyvani K., et al. Transgenic Alzheimer mice in a semi-naturalistic environment: more plaques, yet not compromised in daily life. Behav Brain Res 2009, 201:99-102.
28. Lopez O.L., Becker J.T., Sweet R.A., Klunk W., Kaufer D.I., Saxton J., et al. Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease. J Neuropsychiatry Clin Neurosci 2003, 15:346-353.
29. Lovasic L., Bauschke H., Janus C. Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease. Genes Brain Behav 2005, 4:197-208.
30. Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639.
31. McCool M.F., Varty G.B., Del Vecchio R.A., Kazdoba T.M., Parker E.M., Hunter J.C., et al. Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein. Brain Res 2003, 994:99-106.
32. McKeel D.W., Price J.L., Miller J.P., Grant E.A., Xiong C., Berg L., et al. Neuropathologic criteria for diagnosing Alzheimer disease in persons with pure dementia of Alzheimer type. J Neuropathol Exp Neurol 2004, 63:1028-1037.
33. Minati L., Edginton T., Bruzzone M.G., Giaccone G. Current concepts in Alzheimer's disease: a multidisciplinary review. Am J Alzheimers Dis Other Demen 2009, 24:95-121.
34. Morrissette D.A., Parachikova A., Green K.N., LaFerla F.M. Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem 2009, 284:6033-6037.
35. Nazarali A.J., Reynolds G.P. Monoamine neurotransmitters and their metabolites in brain regions in Alzheimer's disease: a postmortem study. Cell Mol Neurobiol 1992, 12:581-587.
36. Pietropaolo S., Feldon J., Yee B.K. Age-dependent phenotype characteristic of a triple transgenic model of Alzheimer disease. Behav Neurosci 2008, 122:733-747.
37. Prut L., Abramowski D., Krucker T., Levy C.L., Roberts A.J., Staufenbiel M., et al. Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze. Behav Brain Res 2007, 179:107-110.
38. Pugh P.L., Richardson J.C., Bate S.T., Upton N., Sunter D. Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease. Behav Brain Res 2007, 178:18-28.
39. Querfurth H.W., LaFerla F.M. Alzheimer's disease. N Eng J Med 2010, 362:329-344.
40. Reisberg B., Borenstein J., Salob S.P., Ferris S.H., Franssen E., Georgotas A. Behavioral symptoms in Alzheimer's disease phenomenology and treatment. J Clin Psychiatry 1987, 48:9-15.
41. Richter H., Ambrée O., Lewejohann L., Herring A., Keyvani K., Paulus W. Wheel-running in a transgenic model of Alzheimer's disease: Protection or symptom?. Behav Brain Res 2008, 190:74-84.
42. Rogers D.C., Jones D.N.C., Nelson P.R., Jones C.M., Quilter C.A., Robinson T.L., et al. Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains. Behav Brain Res 1999, 105:207-217.
43. Thal D.R., Capetillo-Zarate E., Del Tredici K., Braak H. The development of amyloid protein deposits in the aged brain. Sci Aging Knowl Environ 2006, 6:re1.
44. Touma C., Ambrée O., Görtz N., Keyvani K., Lewejohann L., Palme R. Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic model of Alzheimer's disease. Neurobiol Aging 2004, 25:893-904.
45. Van Dam D., D'Hooge R., Staufenbiel M., Van Ginneken C., Van Meir F., De Deyn P.P. Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. Eur J Neurosci 2003, 17:388-396.
46. Walsh D.M., Selkoe D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004, 44:181-193.
47. Wishaw I.Q., Tomie J.A. Of mice and mazes: similarities between mice and rats on dry land but not water mazes. Physiol Behav 1996, 60:1191-1197.