Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Journal of Medicinal Chemistry

Volumn 60, Issue 1, 2017, Pages 215-227

  Fong, July ^a,d   Yuan, Mingjun ^a   Jakobsen, Tim Holm ^b   Mortensen, Kim T ^c   Delos Santos, May Margarette Salido ^a   Chua, Song Lin ^a   Yang, Liang ^a,d   Tan, Choon Hong ^a,e   Nielsen, Thomas E ^a,b   Givskov, Michael ^a,b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^e Nanyang Technological University   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALLYL 2 BENZYLDISULFANE; 1,2 BIS(6 ETHOXYBENZO[D]THIAZOL 2 YL)DISULFANE; 1,2 BIS(6 METHYLBENZO[D]THIAZOL 2 YL)DISULFANE; 1,2 BIS[6 (TRIFLUOROMETHYL)BENZO[D]THIAZOL 2 YL)DISULFANE; 2 (ALLYLDISULFANYL) 5 METHOXYBENZOOXAZOLE; 2 (ALLYLDISULFANYL) 6 (TRIFLUOROMETHYL)BENZO[D]THIAZOLE; 2 (ALLYLDISULFANYL) 6 CHLOROBENZOOXAZOLE; 2 (ALLYLDISULFANYL) 6 CHLOROBENZO[D]THIAZOLE; 2 (ALLYLDISULFANYL) 6 ETHOXYBENZO[D]THIAZOLE; 2 (ALLYLDISULFANYL) 6 METHYLBENZO[D]THIAZOLE; 2 (ALLYLDISULFANYL)BENZOTHIAZOLE; 2 (ALLYLTHIO)BENZO[D]THIAZOLE; 2 (BUT 3 EN 1 YLTHIO)BENZO[D]THIAZOLE; 2 (CYCLOHEXYLDISULFANYL)BENZOTHIAZOLE; 2 (PHENYLDISULFANYL)BENZOTHIAZOLE; 2 (PROPYLDISULFANYL)BENZOTHIAZOLE; 2 (PROPYLTHIO)BENZO[D]THIAZOLE; 2 [(4 CHLOROPHENYL)DISULFANYL) 6 (TRIFLUOROMETHYL)BENZO[D]THIAZOLE; 2 [(4 CHLOROPHENYL)DISULFANYL) 6 METHYLBENZO[D]THIAZOLE; 2 [(4 CHLOROPHENYL)DISULFANYL] 6 ETHOXYBENZO[D]THIAZOLE; 2 [(4 CHLOROPHENYL)DISULFANYL]BENZOTHIAZOLE; 2 [(4 CHLOROPHENYL)THIO]BENZO[D]THIAZOLE; 2 [(4 METHOXYPHENYL)DISULFANYL]BENZOTHIAZOLE; 6 CHLORO 2 [(4 CHLOROPHENYL)DISULFANYL)BENZO[D]THIAZOLE; BENZOTHIAZOLE DERIVATIVE; ELASTASE; PYOCYANINE; RHAMNOLIPID; SULFUR DERIVATIVE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; AJOENE; ANTIINFECTIVE AGENT; DISULFIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IC50; IMPLANT; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUORUM SENSING; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECTS; PATHOGENICITY; STRUCTURE ACTIVITY RELATION; VIRULENCE;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE; DISULFIDES; FEMALE; MICE; MICE, INBRED BALB C; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; STRUCTURE-ACTIVITY RELATIONSHIP; VIRULENCE;

EID: 85018473138     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01025     Document Type: Article

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