Structure-activity relationships of 2-benzylsulfanylbenzothiazoles: Synthesis and selective antimycobacterial properties

Medicinal Chemistry

Volumn 8, Issue 2, 2012, Pages 281-292

  Klimešová, Věra ^a   Kǒí, Jan ^a   Palát, Karel ^a   Stolaříková, Jiřina ^b   Dahse, Hans Martin ^c   Möllmann, Ute ^c  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b Zdravotniho ustavu se sidlem v Ostrave   (Czech Republic)

^c HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Antimicrobial activity; Benzothiazole; Cytotoxicity; Multidrug resistant M. tuberculosis; Mycobacterium tuberculosis

Indexed keywords

2 (2 CHLOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (2 FLUORO 6 CHLOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (2 FLUORO 6 NITROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (2 FLUOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 BROMOBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 CHLOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 CYANOBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 FLUOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 METHOXYBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 METHYLBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 NITROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3 TRIFLUOROMETHYLBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3,4 DICHLOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3,4 DIFLUOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (3,5 DINITROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (4 CYANOBENZYLSULFANYL)BENZOTHIAZOLE; 2 (4 FLUOROBENZYLSULFANYL)BENZOTHIAZOLE; 2 (4 METHYLBENZYLSULFANYL)BENZOTHIAZOLE; 2 (4 TRIFLUOROMETHYLBENZYLSULFANYL)BENZOTHIAZOLE; 2 [3,5 BIS(TRIFLUOROMETHYL)BENZYLSULFANYL]BENZOTHIAZOLE; 3 (2 BENZOTHIAZOLYLSULFANYLMETHYL)BENZOTHIOAMIDE; ANTIMYCOBACTERIAL AGENT; BENZOTHIAZOLE DERIVATIVE; ISONIAZID; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; IN VITRO STUDY; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEUS VULGARIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

EID: 84861926034     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/157340612800493593     Document Type: Article

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