Quorum sensing: A novel target for the treatment of biofilm infections

BioDrugs

Volumn 17, Issue 4, 2003, Pages 241-250

  Hentzer, Morten ^a   Eberl, Leo ^b   Nielsen, John ^c   Givskov, Michael ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

(N BUTYRYL)HOMOSERINE LACTONE; ACATERIN; ACATERIN DERIVATIVE; ACYL CARRIER PROTEIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BIOCIDE; BUTENOLIDE; C 30; C 56; CELL RECEPTOR; CHOLESTEROL ACYLTRANSFERASE; COGNATE RECEPTOR; DISINFECTANT AGENT; DODECYL SULFATE SODIUM; FURANONE DERIVATIVE; ISOCLADOSPOLIDE B; ISOCLADOSPOLIDE B DERIVATIVE; N (3 OXO DODECANOYL)HOMOSERINE LACTONE; N (3 OXO HEXANOYL)HOMOSERINE LACTONE; N ACYLHOMOSERINE LACTONE; N ACYLHOMOSERINE LACTONE DERIVATIVE; N HEXANOYLHOMOSERINE LACTONE; N HEXANOYLHOMOSERINE LACTONE DERIVATIVE; QUORUM SENSING INHIBITOR; S ADENOSYLMETHIONINE; SYNTHETASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRULENCE FACTOR;

ANTIBIOTIC RESISTANCE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BACTERIUM COLONY; BACTERIUM CULTURE; BACTERIUM MUTANT; BIOFILM; CHIRALITY; CHRONIC DISEASE; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; DRUG DEGRADATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG UTILIZATION; ENZYME ACTIVITY; ENZYME INHIBITION; FOULING CONTROL; GENE EXPRESSION REGULATION; GRAM NEGATIVE BACTERIUM; GROWTH INHIBITION; HOST RESISTANCE; INFECTION CONTROL; MICROBIAL POPULATION DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; NUTRIENT AVAILABILITY; OXYGEN TRANSPORT; POPULATION DENSITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RECEPTOR BLOCKING; REGULATOR GENE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; PSEUDOMONAS INFECTIONS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TECHNOLOGY, PHARMACEUTICAL;

EID: 0041733085     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200317040-00003     Document Type: Review

References (63)

1. O'Toole G, Kaplan HB, Kolter R. Biofilm formation as microbial development. Annu Rev Microbiol 2000; 54: 49-79
2. Tolker-Nielsen T, Molin S. Spatial organization of microbial biofilm communities. Microb Ecol 2000; 40 (2): 75-84
3. Costerton JW, Cheng KJ, Geesey GG, et al. Bacterial biofilms in nature and disease. Annu Rev Microbiol 1987; 41: 435-464
4. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999; 284 (5418): 1318-22
5. Xu KD, McFeters GA, Stewart PS. Biofilm resistance to antimicrobial agents. Microbiology 2000; 146 (Pt 3): 547-9
6. Lewis K. Riddle of biofilm resistance. Antimicrob Agents Chemother 2001; 45 (4): 999-1007
7. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet 2001 Jul 14; 358 (9276): 135-8
8. Govan JR, Deretic V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 1996; 60 (3): 539-74
9. Koch C, Hoiby N. Pathogenesis of cystic fibrosis. Lancet 1993; 341 (8852): 1065-9
10. Tummler B, Kiewitz C. Cystic fibrosis: an inherited susceptibility to bacterial respiratory infections. Mol Med Today 1999; 5 (8): 351-8
11. Lam J, Chan R, Lam K, et al. Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis. Infect Immun 1980; 28 (2): 546-56
12. Worlitzsch D, Tarran R, Ulrich M, et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 2002; 109 (3): 317-25
13. Hassett DJ, Cuppoletti J, Trapnell B, et al. Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets. Adv Drug Deliv Rev 2002; 54 (11): 1425-43
14. Singh PK, Schaefer AL, Parsek MR, et al. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 2000; 407 (6805): 762-4
15. Hentzer M, Wu H, Andersen JB, et al. Attenuation of Pseudomonas aeruginosa virulence by quorum-sensing inhibitors. EMBO J 2003; 22 (15): 1-13
16. Schuster M, Lostroh CP, Ogi T, et al. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J Bacteriol 2003; 185 (7): 2066-79
17. Whiteley M, Lee KM, Greenberg EP. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 1999; 96 (24): 13904-9
18. Davies DG, Parsek MR, Pearson JP, et al. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 1998; 280 (5361): 295-8
19. Eberl L, Winson MK, Sternberg C, et al. Involvement of N-acyl-L-homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens. Mol Microbiol 1996; 20 (1): 127-36
20. Huber B, Riedel K, Hentzer M, et al. The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility. Microbiology 2001; 147 (Pt 9): 2517-28
21. Lynch MJ, Swift S, Kirke DF, et al. The regulation of biofilm development by quorum sensing in Aeromonas hydrophila. Environ Microbiol 2002; 4: 18-28
22. Hentzer M, Riedel K, Rasmussen TB, et al. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 2002; 148 (1): 87-102
23. Eberl L. N-acyl homoserinelactone-mediated gene regulation in gram-negative bacteria. Syst Appl Microbiol 1999; 22 (4): 493-506
24. Riedel K, Hentzer M, Geisenberger O, et al. N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. Microbiology 2001; 147 (12): 3249-62
25. Rasmussen TB, Manefield M, Andersen JB, et al. How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MGI, Microbiology 2000; 146 (Pt 12): 3237-44
26. Hartman G, Wise R. Quorum sensing: potential means of treating gram-negative infections? Lancet 1998; 351 (9106): 848-9
27. Finch RG, Pritchard DI, Bycroft BW, et al. Quorum sensing: a novel target for anti-infective therapy. J Antimicrob Chemother 1998; 42 (5): 569-71
28. Dong YH, Wang LH, Xu JL, et al. Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature 2001 Jun 14; 411 (6839): 813-7
29. Schaefer AL, Hanzelka BL, Eberhard A, et al. Quorum sensing in Vibrio fischeri: probing autoinducer-LuxR interactions with autoinducer analogs. J Bacteriol 1996; 178 (10): 2897-901
30. Chhabra SR, Stead P, Bainton NJ, et al. Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactone. J Antibiot (Tokyo) 1993; 46 (3): 441-54
31. Passador L, Tucker KD, Guertin KR, et al. Functional analysis of the Pseudomonas aeruginosa autoinducer PAI. J Bacteriol 1996; 178 (20): 5995-6000
32. Zhu J, Beaber JW, More MI, et al. Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens. J Bacteriol 1998; 180 (20): 5398-405
33. Kline T, Bowman J, Iglewski BH, et al. Novel synthetic analogs of the Pseudomonas autoinducer. Bioorg Med Chem Lett 1999; 9 (24): 3447-52
34. Ikeda T, Kajiyama K, Kita T, et al. The synthesis of optically pure enantiomers of N-acyl-homoserine lactone autoinducers and their analogues. Chem Lett (Jpn) 2001; 314-315
35. McClean KH, Winson MK, Fish L, et al. Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiology 1997; 143 (12): 3703-11
36. Olsen JA, Severinsen R, Rasmussen TB, et al. Synthesis of new 3- and 4- substituted analogues of acyl homoserine lactone quorum-sensing autoinducers. Bioorg Med Chem Lett 2002 Feb 11; 12 (3): 325-8
37. Joint I, Tait K, Callow ME, et al. Cell-to-cell communication across the prokaryote-eukaryote boundary. Science 2002; 298 (5596): 1207
38. Teplitski M, Robinson JB, Bauer WD. Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria. Mol Plant Microbe Interact 2000; 13 (6): 637-48
39. Cha C, Gao P, Chen YC, et al. Production of acyl-homoserine lactone quorum-sensing signals by Gram-negative plant-associated bacteria. Mol Plant Microbe Interact 1998; 11 (11): 1119-29
40. Parsek MR, Greenberg EP. Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc Natl Acad Sci U S A 2000; 97 (16): 8789-93
41. Pierson EA, Wood DW, Cannon JA, et al. Interpopulation signaling via N-acyl-homoserine lactones among bacteria in the wheat rhizosphere. Mol Plant Microbe Interact 1998; 11: 1078-84
42. Steidle A, Sigl K, Schuhegger R, et al. Visualization of N-acylhomoserine lactone-mediated cell-cell communication between bacteria colonizing the tomato rhizosphere. Appl Environ Microbiol 2001; 67 (12): 5761-70
43. Mathesius U, Mulders S, Gao M, et al. Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals. Proc Natl Acad Sci U S A 2003; 100 (3): 1444-9
44. de Nys R, Wright AD, König GM, et al. New halogenated furanones from the marine alga Delisea pulchra. Tetrahedron 1993; 49 (48): 11213-20
45. de Nys R, Steinberg P, Rogers CN, et al. Quantitative variation of secondary metabolites in the sea hare Apylsia parvula and its host plant. Delisea pulchra. Mar Ecol Prog Ser 1996; 130: 135-46
46. de Nys R, Steinberg PD, Willemsen P, et al. Broad spectrum effects of secondary metabolites from the red alga Delisea pulchra in antifouling assays. Biofouling 1995; 8: 259-71
47. Reichelt JL, Borowitzka MA. Antimicrobial activity from marine algae: results of a large-scale screening programme. Hydrobiology 1984; 116/117: 158-68
48. Rice SA, Givskov M, Steinberg P, et al. Bacterial signals and antagonists: the interaction between bacteria and higher organisms. J Mol Microbiol Biotechnol 1999; 1 (1): 23-31
49. Kjelleberg S, Steinberg PD, Givskov M, et al. Do marine natural products interfere with prokaryotic AHL regulatory systems? Aquat Microb Ecol 1997; 13 (1): 85-93
50. Givskov M, de Nys R, Manefield M, et al. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. J Bacteriol 1996; 178 (22): 6618-22
51. Manefield M, de Nys R, Kumar N, et al. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology 1999; 145: 283-91
52. Manefield M, Rasmussen TB, Henzter M, et al. Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiology 2002; 148 (Pt 4): 1119-27
53. Manefield M, Harris L, Rice SA, et al. Inhibition of luminescence and virulence in the black tiger prawn (Penaeus monodon) pathogen Vibrio harveyi by intercellular signal antagonists. Appl Environ Microbiol 2000; 66 (5): 2079-84
54. Manefield M, Welch M, Givskov M, et al. Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. FEMS Microbiol Lett 2001; 205 (1): 131-8
55. Gram L, Ravn L, Rasch M, et al. Food spoilage: interactions between food spoilage bacteria. Int J Food Microbiol 2002; 78 (1-2): 79-97
56. Hjelmgaard T, Persson T, Rasmussen TB, et al. Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity. Bioorg Med Chem 2003; 11 (15): 3261-3271
57. Spoering AL, Lewis K. Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials. J Bacteriol 2001; 183 (23): 6746-51
58. Wu H, Song Z, Hentzer M, et al. Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiology 2000; 146 (10): 2481-93
59. Chhabra SR, Harty C, Hooi DS, et al. Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. J Med Chem 2003; 46 (1): 97-104
60. DiMango E, Zar HJ, Bryan R, et al. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 1995; 96 (5): 2204-10
61. Telford G, Wheeler D, Williams P, et al. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infect Immun 1998; 66 (1): 36-42
62. Lawrence RN, Dunn WR, Bycroft B, et al. The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction. Br J Pharmacol 1999; 128 (4): 845-8
63. Saleh A, Figarella C, Kammouni W, et al. Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells. Infect Immun 1999; 67 (10): 5076-82