Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

APMIS

Volumn 117, Issue 7, 2009, Pages 537-546

  Van Gennip, Maria ^a   Christensen, Louise Dahl ^a   Alhede, Morten ^b   Phipps, Richard ^b   Jensen, Peter Østrup ^c   Christophersen, Lars ^c   Pamp, Sünje Johanna ^b   Moser, Claus ^c   Mikkelsen, Per Jensen ^d   Koh, Andrew Y ^d   Tolker Nielsen, Tim ^a   Pier, Gerald B ^d   HØiby, Niels ^a,c   Givskov, Michael ^a   Bjarnsholt, Thomas ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c Rigshospitalet   (Denmark)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Biofilm; Mouse models; PMN; Pseudomonas aeruginosa; Rhamnolipid

Indexed keywords

RHAMNOLIPID; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL STRAIN; BIOFILM; FEMALE; FOREIGN BODY; GENE INACTIVATION; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RHLA GENE; WILD TYPE;

ANIMALS; BIOFILMS; COLONY COUNT, MICROBIAL; DNA, BACTERIAL; FEMALE; GENE SILENCING; GLYCOLIPIDS; MICE; MICE, INBRED BALB C; NEUTROPHILS; POINT MUTATION; PROSTHESES AND IMPLANTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUORUM SENSING;

EID: 67651156070     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2009.02466.x     Document Type: Article

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