Allicin and derivates are cysteine protease inhibitors with antiparasitic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5541-5543

  Waag, Thilo ^a   Gelhaus, Christoph ^b   Rath, Jennifer ^c   Stich, August ^c   Leippe, Matthias ^b   Schirmeister, Tanja ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c Medical Mission Hospital   (Germany)

Author keywords

Allicin; Cysteine protease; Inhibitor; Parasite; Thiosulfinate

Indexed keywords

ALLICIN; ALLICIN DERIVATIVE; ANTIPARASITIC AGENT; CARBON; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2; RHODESAIN; SULFUR; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ANIMALS; ANTIPARASITIC AGENTS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; GARLIC; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; SULFINIC ACIDS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI BRUCEI;

EID: 77956180484     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.062     Document Type: Article

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