Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes

Human Molecular Genetics

Volumn 26, Issue 5, 2017, Pages 969-988

  Tanaka, Yoshinori ^a,b   Suzuki, Genjiro ^a   Matsuwaki, Takashi ^b   Hosokawa, Masato ^a   Serrano, Geidy ^c   Beach, Thomas G ^c   Yamanouchi, Keitaro ^b   Hasegawa, Masato ^a   Nishihara, Masugi ^b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN D; CATION; PROGRANULIN; SOMATOMEDIN B RECEPTOR; SORTILIN; DNA BINDING PROTEIN; GRN PROTEIN, HUMAN; LYSOSOMAL PROTEINS; PROTEIN; SIGNAL PEPTIDE; TDP-43 PROTEIN, HUMAN;

ACIDIFICATION; ARTICLE; BIOGENESIS; BRAIN TISSUE; CONTROLLED STUDY; DOWN REGULATION; FRONTOTEMPORAL DEMENTIA; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STARVATION; TDP 43 PROTEINOPATHY; ANIMAL; BIOSYNTHESIS; BRAIN; GENE EXPRESSION REGULATION; GENETICS; HAPLOINSUFFICIENCY; METABOLISM; MUTATION; NERVE CELL; NEUROBLASTOMA; PATHOLOGY; PRIMARY CELL CULTURE;

ANIMALS; BRAIN; CATHEPSIN D; DNA-BINDING PROTEINS; FRONTOTEMPORAL LOBAR DEGENERATION; GENE EXPRESSION REGULATION; HAPLOINSUFFICIENCY; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOMES; MICE; MUTATION; NEUROBLASTOMA; NEURONS; PRIMARY CELL CULTURE; PROTEINS;

EID: 85018403556     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddx011     Document Type: Article

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