Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency

PLoS Pathogens

Volumn 13, Issue 4, 2017, Pages

  Mariggiò, Giuseppe ^a,b   Koch, Sandra ^a,b   Zhang, Guigen ^a,b   Weidner Glunde, Magdalena ^a,b   Rückert, Jessica ^a,b   Kati, Semra ^a,b   Santag, Susann ^a,b   Schulz, Thomas F ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LATENCY ASSOCIATED NUCLEAR ANTIGEN; MRE11 PROTEIN; NIBRIN; PEPTIDES AND PROTEINS; RAD50 PROTEIN; SYNAPTOTAGMIN I; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; DNA LIGASE; ISOPROTEIN; LATENCY-ASSOCIATED NUCLEAR ANTIGEN; MRE11A PROTEIN, HUMAN; NBN PROTEIN, HUMAN; NUCLEAR PROTEIN; RAD50 PROTEIN, HUMAN; VIRUS ANTIGEN; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INNATE IMMUNITY; LUCIFERASE ASSAY; MISMATCH REPAIR; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRUS LATENCY; VIRUS REPLICATION; BIOLOGICAL MODEL; CYTOPLASM; DNA REPLICATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; KAPOSI SARCOMA; METABOLISM; PHYSIOLOGY; VIROLOGY;

ANTIGENS, VIRAL; CELL CYCLE PROTEINS; CYTOPLASM; DNA REPAIR ENZYMES; DNA REPLICATION; DNA, VIRAL; DNA-BINDING PROTEINS; HEK293 CELLS; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNITY, INNATE; MODELS, BIOLOGICAL; NF-KAPPA B; NUCLEAR PROTEINS; PROTEIN ISOFORMS; SARCOMA, KAPOSI; SIGNAL TRANSDUCTION; VIRUS LATENCY; VIRUS REPLICATION;

EID: 85018279901     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006335     Document Type: Article

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