Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity

Journal of Medicinal Chemistry

Volumn 60, Issue 7, 2017, Pages 2963-2972

  Mpakali, Anastasia ^a   Saridakis, Emmanuel ^a   Harlos, Karl ^b   Zhao, Yuguang ^b   Kokkala, Paraskevi ^c   Georgiadis, Dimitris ^c   Giastas, Petros ^a   Papakyriakou, Athanasios ^a   Stratikos, Efstratios ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ERAP1 PROTIEN; ERAP2 PROTEIN; INSULIN REGULATED AMINOPEPTIDASE; UNCLASSIFIED DRUG; CYSTYL AMINOPEPTIDASE; ENZYME INHIBITOR; LEUCYL-CYSTINYL AMINOPEPTIDASE; LIGAND; PEPTIDE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; LIGAND BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTINYL AMINOPEPTIDASE; ENZYME INHIBITORS; HUMANS; LIGANDS; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 85017568829     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01890     Document Type: Article

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