Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

FASEB Journal

Volumn 22, Issue 12, 2008, Pages 4209-4217

  Albiston, Anthony L ^a   Morton, Craig J ^c   Hooi, Ling Ng ^c   Pham, Vi ^a   Yeatman, Holly R ^a   Ye, Siying ^a,d   Fernando, Ruani N ^a,e   De Bundel, Dimitri ^a,f   Ascher, David B ^c   Mendelsohn, Frederick A O ^a   Parker, Michael W ^b,c   Siew, Yeen Chai ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

^f VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Drug development; Facilitation of memory; Glucose uptake; Homology model; Virtual screening

Indexed keywords

AMINOPEPTIDASE; ENZYME INHIBITOR; ETHYL 2 ACETYLAMINO 7 HYDROXY 4 PYRIDIN 3 YL 4H CHROMENE 3 CARBOXYLATE; ETHYL 2 ACETYLAMINO 7 HYDROXY 4 QUINOLIN 3 YL 4H CHROMENE 3 CARBOXYLATE; HFI 14; HFI 142; HFI 419; HFI 435; HFI 437; INSULIN REGULATED AMINOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CATALYSIS; COGNITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; GLUCOSE TRANSPORT; MALE; MEMORY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; RAT; RECOGNITION; WORKING MEMORY;

ANIMALS; BIOLOGICAL ASSAY; CATALYTIC DOMAIN; CYSTINYL AMINOPEPTIDASE; DRUG DESIGN; ENZYME INHIBITORS; MALE; MEMORY; MODELS, MOLECULAR; NOOTROPIC AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECOGNITION (PSYCHOLOGY);

RATTUS; RODENTIA;

EID: 57349101001     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-112227     Document Type: Article

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