Rationally designed inhibitor targeting antigentrimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 49, 2013, Pages 19890-19895

  Zervoudi, Efthalia ^a   Saridakis, Emmanuel ^a   Birtley, James R ^a   Seregin, Sergey S ^b   Reeves, Emma ^c   Kokkala, Paraskevi ^d   Aldhamen, Yasser A ^b   Amalfitano, Andrea ^b   Mavridis, Irene M ^a   James, Edward ^c   Georgiadis, Dimitris ^d   Stratikos, Efstratios ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b Michigan State University   (United States)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY OF ATHENS   (Greece)

Author keywords

Adaptive immunity; Kinetics; Major histocompatibility molecules; Molecular structure; Specificity

Indexed keywords

AMINOPEPTIDASE; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2; EPITOPE; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CANCER CELL; CANCER IMMUNOTHERAPY; CHEMICAL ANALYSIS; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

MURINAE;

EID: 84889671845     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1309781110     Document Type: Article

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