3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of m1 aminopeptidases with immune-regulating properties

Journal of Medicinal Chemistry

Volumn 58, Issue 3, 2015, Pages 1524-1543

  Papakyriakou, Athanasios ^a,b   Zervoudi, Efthalia ^a   Tsoukalidou, Sofia ^a   Mauvais, Francois Xavier ^c   Sfyroera, Georgia ^a   Mastellos, Dimitrios C ^a   Van Endert, Peter ^c   Theodorakis, Emmanuel A ^b   Vourloumis, Dionisios ^a   Stratikos, Efstratios ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIAMINOBENZOIC ACID DERIVATIVE; 4 AMINO 3 (2 AMINO 4 METHYLPENTANAMIDO)BENZOIC ACID; 4 AMINO 3 (2 AMINO 5 GUANIDINOPENTANAMIDO)BENZOIC; 4 AMINO 3 [2 AMINO 3 (4 HYDROXYPHENYL)PROPANAMIDO]BENZOIC ACID; 4 AMINO 3 [2 AMINO 3 [4 (BENZYLOXY)PHENYL]PROPANAMIDO]BENZOATE ACID; 5 AMINO 2 [4 AMINO 3 (2 AMINO 4 PHENYLBUTANAMIDO)BENZAMIDO]PENTANOIC ACID; 6 AMINO 2 [4 AMINO 3 (2 AMINO 3 PHENYLPROPANAMIDO)BENZAMIDO]HEXANOIC ACID; 6 AMINO 2 [4 AMINO 3 [2 AMINO 3 (4 HYDROXYPHENYL)PROPANAMIDO]BENZAMIDO]HEXANOIC ACID; AMINOPEPTIDASE; AMINOPEPTIDASE INHIBITOR; BENZOIC ACID DERIVATIVE; CYSTYL AMINOPEPTIDASE; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2; GAMMA INTERFERON; INSULIN REGULATED AMINOPEPTIDASE; LIPOPOLYSACCHARIDE; METHYL 4 AMINO 3 (2 AMINO 4 METHYLPENTANAMIDO)BENZOATE; METHYL 4 AMINO 3 (2 AMINO 5 GUANIDINOPENTANAMIDO)BENZOATE; METHYL 4 AMINO 3 (2 AMINOHEXANAMIDO)BENZOATE; METHYL 4 AMINO 3 [2 AMINO 3 (4 HYDROXYPHENYL)PROPANAMIDO]BENZOATE; METHYL 4 AMINO 3 [2 AMINO 3 [4 (BENZYLOXY)PHENYL]PROPANAMIDO]BENZOATE; METHYL 4 AMINO 3 [2 AMINO 4 (4 HYDROXYPHENYL)BUTANAMIDO]BENZOATE; METHYL 4 AMINO 3 [2 AMINO 4 [4 (BENZYLOXY)PHENYL]BUTANAMIDO]BENZOATE; METHYL 5 AMINO 2 [4 AMINO 3 (2 AMINO 4 PHENYLBUTANAMIDO)BENZAMIDO]PENTANOATE; METHYL 6 AMINO 2 [4 AMINO 3 (2 AMINO 4 METHYLPENATANAMIDO)BENZAMIDO]HEXANOATE; METHYL 6 AMINO 2 [4 AMINO 3 [2 AMINO 3 (BENZYLOXYL)PROPANAMIDO]BENZAMIDO]HEXANOATE; METHYL 6 AMINO 2 [4 AMINO 3 [2 AMINO 4 (4 HYDROXYPHENYL)BUTANAMIDO]BENZAMIDO]HEXANOATE; METHYL 6 AMINO 2 [4 AMINO 3 [2 AMINO 4 [4(BENZYLOXY)BUTANAMIDO]BENZAMIDO]HEXANOATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 3,4-DIAMINOBENZOIC ACID; AMINOBENZOIC ACID DERIVATIVE; ENZYME INHIBITOR;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS PRESENTATION; DOWN REGULATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; IC50; IMMUNE RESPONSE; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; IMMUNOLOGY; METABOLISM; SYNTHESIS;

AMINOBENZOATES; AMINOPEPTIDASES; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922810539     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501867s     Document Type: Article

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