Whole-Cell-Based Assay to Evaluate Structure Permeation Relationships for Carbapenem Passage through the Pseudomonas aeruginosa Porin OprD

ACS Infectious Diseases

Volumn 3, Issue 4, 2017, Pages 310-319

  Iyer, Ramkumar ^a   Sylvester, Mark A ^a   Velez Vega, Camilo ^a   Tommasi, Ruben ^a   Durand Reville, Thomas F ^a   Miller, Alita A ^a  

^a Entasis Therapeutics   (United States)

Author keywords

antibiotic; carbapenem; OprD; permeation; porin; Pseudomonas aeruginosa

Indexed keywords

AZTREONAM; BIAPENEM; CARBAPENEM; CARBENICILLIN; DORIPENEM; FROPENEM; IMIPENEM; MEROPENEM; PORIN; TETRACYCLINE; CARBAPENEM DERIVATIVE; OPRD PROTEIN, PSEUDOMONAS AERUGINOSA;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OUTER MEMBRANE; PHYSICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; TITRABLE OUTER MEMBRANE PERMEABILITY ASSAY SYSTEM; WESTERN BLOTTING; WHOLE CELL; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION;

CARBAPENEMS; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; PORINS; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85017565662     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.6b00197     Document Type: Article

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