Molecular Basis of filtering carbapenems by porins from βlactam-resistant clinical strains of Escherichia coli

Journal of Biological Chemistry

Volumn 291, Issue 6, 2016, Pages 2837-2847

  Bajaj, Harsha ^a   Scorciapino, Mariano A ^b   Moynie, Lucile ^c   Page, Malcolm G P ^d   Naismith, James H ^c   Ceccarelli, Matteo ^b   Winterhalter, Mathias ^a  

^a JACOBS UNIVERSITY BREMEN   (Germany)

^b Department of Physics ^*  (Italy)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

^d BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOLOGICAL MEMBRANES; CHEMOTHERAPY; ELECTRIC FIELDS; ELECTROPHYSIOLOGY; ESCHERICHIA COLI; MOLECULAR DYNAMICS; MOLECULAR ORIENTATION; PERMEATION;

CLINICAL RESISTANCE; GRAM-NEGATIVE BACTERIA; INTEGRAL MEMBRANE PROTEINS; LIPOSOME PERMEATION; PERMEATION PROPERTIES; SINGLE-CHANNEL ELECTROPHYSIOLOGY; SINGLE-POINT MUTATION; SPECIFIC ORIENTATION;

PROTEINS;

AMPHOLYTE; ANTIINFECTIVE AGENT; BETA LACTAM; CARBAPENEM DERIVATIVE; ESCHERICHIA COLI PROTEIN; IMIPENEM; LIPOSOME; MEROPENEM; MUTANT PROTEIN; OMPC20 PROTEIN; OMPC26 PROTEIN; OMPC28 PROTEIN; OMPC33 PROTEIN; OUTER MEMBRANE PROTEIN C; PORIN; UNCLASSIFIED DRUG; THIENAMYCIN DERIVATIVE;

ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ELECTRIC FIELD; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; HUMAN; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIMULATION; ANTIBIOTIC RESISTANCE; CHEMISTRY; GENETICS; METABOLISM; MUTATION;

BETA-LACTAM RESISTANCE; ESCHERICHIA COLI; IMIPENEM; MUTATION; PORINS; THIENAMYCINS;

EID: 84958092458     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.690156     Document Type: Article

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