Carbapenem activities against Pseudomonas aeruginosa: Respective contributions of OprD and efflux systems

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 2, 1999, Pages 424-427

  Köhler, Thilo ^a   Michea Hamzehpour, Mehri ^a   Epp, Simone F ^a   Pechere, Jean Claude ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL PROTEIN OPRD; CARBAPENEM DERIVATIVE; CEFPIROME; E 1010; IMIPENEM; MEROPENEM; SPARFLOXACIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CROSS RESISTANCE; DRUG TRANSPORT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OPERON; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0344572646     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.2.424     Document Type: Article

References (26)

1. Angus, B. L., A. M. Carey, D. A. Caron, A. M. Kropinski, and R. E. Hancock. 1982. Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant. Antimicrob. Agents Chemother. 21:299-309.
2. Chen, H. Y., M. Yuan, and D. M. Livermore. 1995. Mechanisms of resistance to beta-lactam antibiotics amongst Pseudomonas aeruginosa isolates collected in the UK in 1993. J. Med. Microbiol. 43:300-309.
3. Epp, S. F. Unpublished data.
4. Fung-Tomc, J. C., E. Gradelski, B. Kolek, B. Minassian, M. Pucci, R. E. Kessler, and D. P. Bonner. 1995. Activity of carbapenem BMS-181139 against Pseudomonas aeruginosa is not dependent on porin protein D2. Antimicrob. Agents Chemother. 39:385-393.
5. Gotoh, N., H. Tsujimoto, M. Tsuda, K. Okamoto, A. Nomura, T. Wada, M. Nakahashi, and T. Nishino. 1998. Characterization of the MexC-MexD-OprJ multidrug efflux system in ΔmexA-mexB-oprM mutants of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 42:1938-1943.
6. Haas, D., B. W. Holloway, A. Schamböck, and T. Leisinger. 1977. The genetic organization of arginine biosynthesis in Pseudomonas aeruginosa. Mol. Gen. Genet. 154:7-22.
7. Jorgensen, J. H., M. J. Ferraro, W. A. Craig, G. V. Doern, S. M. Finegold, J. Fung-Tomc, S. L. Hansen, J. Hindler, L. B. Reller, J. M. Swenson, F. C. Tenover, R. T. Testa, and M. A. Wikler. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. The National Commitee for Clinical Laboratory Standards. Villanova, Pa.
8. Köhler, T., M. Michea-Hamzehpour, U. Henze, N. Gotoh, L. K. Curty, and J. C. Pechère. 1997. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol. Microbiol. 23:345-354.
9. Köhler, T., M. Michéa-Hamzehpour, P. Plésiat, A. Kahr, and J. C. Pechère. 1997. Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 41:2540-2543.
10. Li, X.-Z., D. Ma, D. M. Livermore, and H. Nikaido. 1994. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as contributing factor to β-lactam resistance. Antimicrob. Agents Chemother. 38:1742-1752.
11. Li, X.-Z., H. Nikaido, and K. Poole. 1995. Role of MexA-MexB-OprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
12. Masuda, N., N. Gotoh, S. Ohya, and T. Nishino. 1996. Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 40:909-913.
13. Masuda, N., and S. Ohya. 1992. Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36:1847-1851.
14. Masuda, N., E. Sakagawa, and S. Ohya. 1995. Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:645-649.
15. Michéa-Hamzehpour, M., J.-C. Pechère, P. Plésiat, and T. Köhler. 1995. OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:2392-2396.
16. Minami, S., M. Akama, H. Araki, Y. Watanabe, H. Narita, S. Iyobe, and S. Mitsuhashi. 1996. Imipenem and cephem resistant Pseudomonas aeruginosa carrying plasmids coding for class B beta-lactamase. J. Antimicrob. Chemother. 37:433-444.
17. Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barrier and active efflux. Science 264:382-388.
18. Nikaido, H. 1996. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:5853-5859.
19. Perez, F. J., C. Gimeno, D. Navarro, and J. Garcia-de-Lomas. 1996. Meropenem permeation through the outer membrane of Pseudomonas aeruginosa can involve pathways other than the OprD porin channel. Chemotherapy 42:210-214.
20. Poole, K., N. Gotoh, H. Tsujimoto, Q. Zhao, A. Wada, T. Yamasaki, S. Neshat, J. Yamagishi, X. Z. Li, and T. Nishino. 1996. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. Mol. Microbiol. 21:713-724.
21. Poole, K., K. Krebes, C. McNally, and S. Neshat. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
22. Smith, G. B., and E. F. Schoenewaldt. 1981. Stability of N-formimidoylthienamycin in aqueous solution. J. Pharm. Sci. 70:272-276.
23. Takeuchi, Y., M. Sunagawa, Y. Isobe, Y. Hamazume, and T. Noguchi. 1995. Stability of a 1 beta-methylcarbapenem antibiotic, meropenem (SM-7338) in aqueous solution. Chem. Pharm. Bull. (Tokyo) 43:689-692.
24. Trias, J., and H. Nikaido. 1990. Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 34:52-57.
25. Yoshimura, F., and H. Nikaido. 1982. Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes. J. Bacteriol. 152:636-642.
26. Ziha-Zarifi, I., C. Llanes, T. Köhler, J. C. Pechere, and P. Plesiat. In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa over-expressing the active efflux system MexA-MexB-OprM. Antimicrob. Agents Chemother., in press.