Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity

Oncotarget

Volumn 8, Issue 15, 2017, Pages 24518-24532

  Gursoy Yuzugullu, Ozge ^a   Carman, Chelsea ^a   Serafim, Rodolfo Bortolozo ^a   Myronakis, Marios ^a   Valente, Valeria ^b   Price, Brendan D ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

DNA repair; G9a; Glioma; Histone methylation; Radiosensitizer

Indexed keywords

ACYLTRANSFERASE; ATM PROTEIN; METHYLTRANSFERASE INHIBITOR; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; TIP60 ACETYLTRANSFERASE; UNC 0379; UNCLASSIFIED DRUG; HISTONE; RADIOSENSITIZING AGENT;

ARTICLE; CANCER RADIOTHERAPY; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; EPIGENETICS; GLIOMA CELL; HISTONE METHYLATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RADIOSENSITIZATION; GENETICS; GLIOMA; METABOLISM; METHYLATION; PATHOLOGY; SIGNAL TRANSDUCTION;

DNA DAMAGE; GLIOMA; HISTONES; HUMANS; METHYLATION; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION;

EID: 85017528654     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.15543     Document Type: Article

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