메뉴 건너뛰기




Volumn 12, Issue 16, 2013, Pages 2675-2683

Polycomb repressive complex 2 contributes to DNA double-strand break repair

Author keywords

Chromatin; DNA damage; Epigenetics; PARP; Polycomb group proteins

Indexed keywords

ATM PROTEIN; HISTONE H2A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN KINASE C; TRANSCRIPTION FACTOR EZH2;

EID: 84883217456     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.25795     Document Type: Article
Times cited : (112)

References (43)
  • 1
    • 70349696541 scopus 로고    scopus 로고
    • Polycomb group protein gene silencing, non-coding rna, stem cells, and cancer
    • PMID:19898523
    • Gieni RS, Hendzel MJ. Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer. Biochem Cell Biol 2009; 87:711-46; PMID:19898523; http://dx.doi.org/10.1139/O09-057
    • (2009) Biochem Cell Biol , vol.87 , pp. 711-746
    • Gieni, R.S.1    Hendzel, M.J.2
  • 2
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone h3 lysine 27 methylation in polycomb-group silencing
    • PMID:12351676
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298:1039-43; PMID:12351676; http://dx.doi.org/10.1126/science.1076997
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 3
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • PMID:17060944
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6:846-56; PMID:17060944; http://dx.doi.org/10.1038/nrc1991
    • (2006) Nat Rev Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 4
    • 0043127085 scopus 로고    scopus 로고
    • Molecular basis for the discrimination of repressive methyl-lysine marks in histone h3 by polycomb and hp1 chromodomains
    • PMID:12897054
    • Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, Khorasanizadeh S. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev 2003; 17:1870-81; PMID:12897054; http://dx.doi.org/10.1101/gad.1110503
    • (2003) Genes Dev , vol.17 , pp. 1870-1881
    • Fischle, W.1    Wang, Y.2    Jacobs, S.A.3    Kim, Y.4    Allis, C.D.5    Khorasanizadeh, S.6
  • 5
    • 0041624288 scopus 로고    scopus 로고
    • Structural basis for specific binding of polycomb chromodomain to histone h3 methylated at lys 27
    • PMID:12897052
    • Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev 2003; 17:1823-8; PMID:12897052; http://dx.doi.org/10.1101/gad.269603
    • (2003) Genes Dev , vol.17 , pp. 1823-1828
    • Min, J.1    Zhang, Y.2    Xu, R.M.3
  • 6
    • 7244234099 scopus 로고    scopus 로고
    • Role of histone h2a ubiquitination in polycomb silencing
    • PMID:15386022
    • Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature 2004; 431:873-8; PMID:15386022; http://dx.doi.org/10.1038/nature02985
    • (2004) Nature , vol.431 , pp. 873-878
    • Wang, H.1    Wang, L.2    Erdjument-Bromage, H.3    Vidal, M.4    Tempst, P.5    Jones, R.S.6
  • 7
    • 77957748289 scopus 로고    scopus 로고
    • Bmi1-mediated histone ubiquitylation promotes dna double-strand break repair
    • PMID:20921134
    • Ismail IH, Andrin C, McDonald D, Hendzel MJ. BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol 2010; 191:45-60; PMID:20921134; http://dx.doi.org/10.1083/jcb.201003034
    • (2010) J Cell Biol , vol.191 , pp. 45-60
    • Ismail, I.H.1    Andrin, C.2    McDonald, D.3    Hendzel, M.J.4
  • 8
    • 79956086415 scopus 로고    scopus 로고
    • Bmi1 is recruited to dna breaks and contributes to dna damage-induced h2a ubiquitination and repair
    • PMID:21383063
    • Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, et al. BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol 2011; 31:1972-82; PMID:21383063; http://dx.doi.org/10.1128/MCB.00981-10
    • (2011) Mol Cell Biol , vol.31 , pp. 1972-1982
    • Ginjala, V.1    Nacerddine, K.2    Kulkarni, A.3    Oza, J.4    Hill, S.J.5    Yao, M.6
  • 9
    • 29244434544 scopus 로고    scopus 로고
    • Mdc1 directly binds phosphorylated histone h2ax to regulate cellular responses to dna double-strand breaks
    • PMID:16377563
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 2005; 123:1213-26; PMID:16377563; http://dx.doi.org/10.1016/j.cell.2005.09.038
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 10
    • 59049091728 scopus 로고    scopus 로고
    • Rnf168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
    • PMID:19203579
    • Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, et al. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 2009; 136:435-46; PMID:19203579; http://dx.doi.org/10.1016/j.cell.2008.12.041
    • (2009) Cell , vol.136 , pp. 435-446
    • Doil, C.1    Mailand, N.2    Bekker-Jensen, S.3    Menard, P.4    Larsen, D.H.5    Pepperkok, R.6
  • 11
    • 78649349810 scopus 로고    scopus 로고
    • A chromatin localization screen reveals poly (adp ribose)-regulated recruitment of the repressive polycomb and nurd complexes to sites of dna damage
    • PMID:20937877
    • Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, et al. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A 2010; 107:18475-80; PMID:20937877; http://dx.doi.org/10.1073/ pnas.1012946107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18475-18480
    • Chou, D.M.1    Adamson, B.2    Dephoure, N.E.3    Tan, X.4    Nottke, A.C.5    Hurov, K.E.6
  • 12
    • 79952633107 scopus 로고    scopus 로고
    • Polycomb group proteins in the dna damage response: A link between radiation resistance and stemness
    • PMID:21346409
    • Gieni RS, Ismail IH, Campbell S, Hendzel MJ. Polycomb group proteins in the DNA damage response: a link between radiation resistance and stemness. Cell Cycle 2011; 10:883-94; PMID:21346409; http://dx.doi.org/10.4161/cc.10.6.14907
    • (2011) Cell Cycle , vol.10 , pp. 883-894
    • Gieni, R.S.1    Ismail, I.H.2    Campbell, S.3    Hendzel, M.J.4
  • 13
    • 78649349810 scopus 로고    scopus 로고
    • A chromatin localization screen reveals poly (adp ribose)-regulated recruitment of the repressive polycomb and nurd complexes to sites of dna damage
    • PMID:20937877
    • Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, et al. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A 2010; 107:18475-80; PMID:20937877; http://dx.doi.org/10.1073/ pnas.1012946107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18475-18480
    • Chou, D.M.1    Adamson, B.2    Dephoure, N.E.3    Tan, X.4    Nottke, A.C.5    Hurov, K.E.6
  • 14
    • 50849104569 scopus 로고    scopus 로고
    • Double strand breaks can initiate gene silencing and sirt1-dependent onset of dna methylation in an exogenous promoter cpg island
    • PMID:18704159
    • O'Hagan HM, Mohammad HP, Baylin SB. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet 2008; 4:e1000155; PMID:18704159; http://dx.doi.org/10.1371/journal.pgen.1000155
    • (2008) PLoS Genet , vol.4
    • O'Hagan, H.M.1    Mohammad, H.P.2    Baylin, S.B.3
  • 15
    • 44349103099 scopus 로고    scopus 로고
    • A polycomb group protein, phf1, is involved in the response to dna double-strand breaks in human cell
    • PMID:18385154
    • Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, et al. A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell. Nucleic Acids Res 2008; 36:2939-47; PMID:18385154; http://dx.doi.org/10.1093/nar/gkn146
    • (2008) Nucleic Acids Res , vol.36 , pp. 2939-2947
    • Hong, Z.1    Jiang, J.2    Lan, L.3    Nakajima, S.4    Kanno, S.5    Koseki, H.6
  • 16
    • 84856177800 scopus 로고    scopus 로고
    • Acetylation-dependent nuclear arrangement and recruitment of bmi1 protein to uv-damaged chromatin
    • PMID:21732356
    • Sustáčková G, Kozubek S, Stixová L, Legartová S, Matula P, Orlova D, et al. Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. J Cell Physiol 2012; 227:1838-50; PMID:21732356; http://dx.doi.org/10.1002/jcp.22912
    • (2012) J Cell Physiol , vol.227 , pp. 50
    • Sustáčková, G.1    Kozubek, S.2    Stixová, L.3    Legartová, S.4    Matula, P.5    Orlova, D.6
  • 17
    • 84855323192 scopus 로고    scopus 로고
    • Prc2 directly methylates gata4 and represses its transcriptional activity
    • PMID:22215809
    • He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, et al. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev 2012; 26:37-42; PMID:22215809; http://dx.doi.org/10.1101/gad.173930.111
    • (2012) Genes Dev , vol.26 , pp. 37-42
    • He, A.1    Shen, X.2    Ma, Q.3    Cao, J.4    Von Gise, A.5    Zhou, P.6
  • 18
    • 33646848438 scopus 로고    scopus 로고
    • Substrate preferences of the ezh2 histone methyltransferase complex
    • PMID:16431907
    • Martin C, Cao R, Zhang Y. Substrate preferences of the EZH2 histone methyltransferase complex. J Biol Chem 2006; 281:8365-70; PMID:16431907; http://dx.doi.org/10.1074/jbc.M513425200
    • (2006) J Biol Chem , vol.281 , pp. 8365-8370
    • Martin, C.1    Cao, R.2    Zhang, Y.3
  • 19
    • 80053935847 scopus 로고    scopus 로고
    • Polycomb protein ezh2 regulates cancer cell fate decision in response to dna damage
    • PMID:21546904
    • Wu Z, Lee ST, Qiao Y, Li Z, Lee PL, Lee YJ, et al. Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage. Cell Death Differ 2011; 18:1771-9; PMID:21546904; http://dx.doi.org/10.1038/cdd.2011.48
    • (2011) Cell Death Differ , vol.18 , pp. 1771-1779
    • Wu, Z.1    Lee, S.T.2    Qiao, Y.3    Li, Z.4    Lee, P.L.5    Lee, Y.J.6
  • 20
    • 84856466661 scopus 로고    scopus 로고
    • The role of ezh2 in tumour progression
    • PMID:22187039
    • Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer 2012; 106:243-7; PMID:22187039; http://dx.doi.org/10.1038/bjc.2011.551
    • (2012) Br J Cancer , vol.106 , pp. 243-247
    • Chang, C.J.1    Hung, M.C.2
  • 21
    • 84856466661 scopus 로고    scopus 로고
    • The role of ezh2 in tumour progression
    • PMID:22187039
    • Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer 2012; 106:243-7; PMID:22187039; http://dx.doi.org/10.1038/bjc.2011.551
    • (2012) Br J Cancer , vol.106 , pp. 243-247
    • Chang, C.J.1    Hung, M.C.2
  • 22
    • 79952633107 scopus 로고    scopus 로고
    • Polycomb group proteins in the dna damage response: A link between radiation resistance and stemness
    • PMID:21346409
    • Gieni RS, Ismail IH, Campbell S, Hendzel MJ. Polycomb group proteins in the DNA damage response: a link between radiation resistance and stemness. Cell Cycle 2011; 10:883-94; PMID:21346409; http://dx.doi.org/10.4161/cc.10.6.14907
    • (2011) Cell Cycle , vol.10 , pp. 883-894
    • Gieni, R.S.1    Ismail, I.H.2    Campbell, S.3    Hendzel, M.J.4
  • 23
    • 77957748289 scopus 로고    scopus 로고
    • Bmi1-mediated histone ubiquitylation promotes dna double-strand break repair
    • PMID:20921134
    • Ismail IH, Andrin C, McDonald D, Hendzel MJ. BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol 2010; 191:45-60; PMID:20921134; http://dx.doi.org/10.1083/jcb.201003034
    • (2010) J Cell Biol , vol.191 , pp. 45-60
    • Ismail, I.H.1    Andrin, C.2    McDonald, D.3    Hendzel, M.J.4
  • 24
    • 34250309207 scopus 로고    scopus 로고
    • In situ analysis of dna damage response and repair using laser microirradiation
    • PMID:17586265
    • Kim JS, Heale JT, Zeng W, Kong X, Krasieva TB, Ball AR Jr., et al. In situ analysis of DNA damage response and repair using laser microirradiation. Methods Cell Biol 2007; 82:377-407; PMID:17586265; http://dx.doi.org/10.1016/ S0091-679X(06)82013-3
    • (2007) Methods Cell Biol , vol.82 , pp. 377-407
    • Kim, J.S.1    Heale, J.T.2    Zeng, W.3    Kong, X.4    Krasieva, T.B.5    Ball Jr., A.R.6
  • 25
    • 84863198650 scopus 로고    scopus 로고
    • Cbx4-mediated sumo modification regulates bmi1 recruitment at sites of dna damage
    • PMID:22402492
    • Ismail IH, Gagné JP, Caron MC, McDonald D, Xu Z, Masson JY, et al. CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage. Nucleic Acids Res 2012; 40:5497-510; PMID:22402492; http://dx.doi.org/ 10.1093/nar/gks222
    • (2012) Nucleic Acids Res , vol.40 , pp. 5497-5510
    • Ismail, I.H.1    Gagné, J.P.2    Caron, M.C.3    McDonald, D.4    Xu, Z.5    Masson, J.Y.6
  • 26
    • 79551665780 scopus 로고    scopus 로고
    • Mmset regulates histone h4k20 methylation and 53bp1 accumulation at dna damage sites
    • PMID:21293379
    • Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, et al. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature 2011; 470:124-8; PMID:21293379; http://dx.doi.org/10.1038/nature09658
    • (2011) Nature , vol.470 , pp. 124-128
    • Pei, H.1    Zhang, L.2    Luo, K.3    Qin, Y.4    Chesi, M.5    Fei, F.6
  • 27
    • 79952256559 scopus 로고    scopus 로고
    • Methylation of histone h3 lysine 36 enhances dna repair by nonhomologous end-joining
    • PMID:21187428
    • Fnu S, Williamson EA, De Haro LP, Brenneman M, Wray J, Shaheen M, et al. Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining. Proc Natl Acad Sci U S A 2011; 108:540-5; PMID:21187428; http://dx.doi.org/10.1073/pnas.1013571108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 540-545
    • Fnu, S.1    Williamson, E.A.2    De Haro, L.P.3    Brenneman, M.4    Wray, J.5    Shaheen, M.6
  • 28
    • 66249147231 scopus 로고    scopus 로고
    • Comparative analysis of different laser systems to study cellular responses to dna damage in mammalian cells
    • PMID:19357094
    • Kong X, Mohanty SK, Stephens J, Heale JT, Gomez-Godinez V, Shi LZ, et al. Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells. Nucleic Acids Res 2009; 37:e68; PMID:19357094; http://dx.doi.org/10.1093/nar/gkp221
    • (2009) Nucleic Acids Res , vol.37
    • Kong, X.1    Mohanty, S.K.2    Stephens, J.3    Heale, J.T.4    Gomez-Godinez, V.5    Shi, L.Z.6
  • 29
    • 77953720192 scopus 로고    scopus 로고
    • Atm-dependent chromatin changes silence transcription in cis to dna double-strand breaks
    • PMID:20550933
    • Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 2010; 141:970-81; PMID:20550933; http://dx.doi.org/ 10.1016/j.cell.2010.04.038
    • (2010) Cell , vol.141 , pp. 970-981
    • Shanbhag, N.M.1    Rafalska-Metcalf, I.U.2    Balane-Bolivar, C.3    Janicki, S.M.4    Greenberg, R.A.5
  • 30
    • 79956086415 scopus 로고    scopus 로고
    • Bmi1 is recruited to dna breaks and contributes to dna damage-induced h2a ubiquitination and repair
    • PMID:21383063
    • Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, et al. BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol 2011; 31:1972-82; PMID:21383063; http://dx.doi.org/10.1128/MCB.00981-10
    • (2011) Mol Cell Biol , vol.31 , pp. 1972-1982
    • Ginjala, V.1    Nacerddine, K.2    Kulkarni, A.3    Oza, J.4    Hill, S.J.5    Yao, M.6
  • 31
    • 78049307003 scopus 로고    scopus 로고
    • Overexpression of ezh2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo
    • PMID:20686362
    • Hu S, Yu L, Li Z, Shen Y, Wang J, Cai J, et al. Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo. Cancer Biol Ther 2010; 10:788-95; PMID:20686362; http://dx.doi.org/10.4161/cbt.10.8.12913
    • (2010) Cancer Biol Ther , vol.10 , pp. 788-795
    • Hu, S.1    Yu, L.2    Li, Z.3    Shen, Y.4    Wang, J.5    Cai, J.6
  • 32
    • 33644826522 scopus 로고    scopus 로고
    • The polycomb group protein ezh2 impairs dna repair in breast epithelial cells
    • PMID:16331887
    • Zeidler M, Varambally S, Cao Q, Chinnaiyan AM, Ferguson DO, Merajver SD, et al. The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells. Neoplasia 2005; 7:1011-9; PMID:16331887; http://dx.doi.org/10.1593/neo. 05472
    • (2005) Neoplasia , vol.710 , pp. 11-19
    • Zeidler, M.1    Varambally, S.2    Cao, Q.3    Chinnaiyan, A.M.4    Ferguson, D.O.5    Merajver, S.D.6
  • 33
    • 0025863346 scopus 로고
    • Identification of cooperating oncogenes in e mu-myc transgenic mice by provirus tagging
    • PMID:1904008
    • van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 1991; 65:737-52; PMID:1904008; http://dx.doi.org/10.1016/ 0092-8674(91)90382-9
    • (1991) Cell , vol.65 , pp. 737-752
    • Van Lohuizen, M.1    Verbeek, S.2    Scheijen, B.3    Wientjens, E.4    Van Der Gulden, H.5    Berns, A.6
  • 34
    • 0035912061 scopus 로고    scopus 로고
    • P14arf homozygous deletion or mdm2 overexpression in burkitt lymphoma lines carrying wild type p53
    • PMID:11360201
    • Lindström MS, Klangby U, Wiman KG. p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53. Oncogene 2001; 20:2171-7; PMID:11360201; http://dx.doi.org/10.1038/sj.onc.1204303
    • (2001) Oncogene , vol.20 , pp. 2171-2177
    • Lindström, M.S.1    Klangby, U.2    Wiman, K.G.3
  • 35
    • 0035877978 scopus 로고    scopus 로고
    • Coexpression of bmi-1 and ezh2 polycomb-group proteins is associated with cycling cells and degree of malignancy in b-cell non-hodgkin lymphoma
    • PMID:11389032
    • van Kemenade FJ, Raaphorst FM, Blokzijl T, Fieret E, Hamer KM, Satijn DP, et al. Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood 2001; 97:3896-901; PMID:11389032; http://dx.doi.org/10.1182/blood. V97.12.3896
    • (2001) Blood , vol.97 , pp. 3896-3901
    • Van Kemenade, F.J.1    Raaphorst, F.M.2    Blokzijl, T.3    Fieret, E.4    Hamer, K.M.5    Satijn, D.P.6
  • 36
    • 0141576562 scopus 로고    scopus 로고
    • Identification of the polycomb group protein su(z)12 as a potential molecular target for human cancer therapy
    • PMID:12533679
    • Kirmizis A, Bartley SM, Farnham PJ. Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy. Mol Cancer Ther 2003; 2:113-21; PMID:12533679
    • (2003) Mol Cancer Ther , vol.2 , pp. 113-121
    • Kirmizis, A.1    Bartley, S.M.2    Farnham, P.J.3
  • 37
    • 3042781030 scopus 로고    scopus 로고
    • Silencing of human polycomb target genes is associated with methylation of histone h3 lys 27
    • PMID:15231737
    • Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, et al. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev 2004; 18:1592-605; PMID:15231737; http://dx.doi.org/10.1101/gad.1200204
    • (2004) Genes Dev , vol.18 , pp. 1592-1605
    • Kirmizis, A.1    Bartley, S.M.2    Kuzmichev, A.3    Margueron, R.4    Reinberg, D.5    Green, R.6
  • 38
    • 0141816752 scopus 로고    scopus 로고
    • Ezh2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • PMID:14500907
    • Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003; 100:11606-11; PMID:14500907; http://dx.doi.org/10.1073/pnas.1933744100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 39
    • 18644382388 scopus 로고    scopus 로고
    • The polycomb group protein ezh2 is involved in progression of prostate cancer
    • PMID:12374981
    • Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419:624-9; PMID:12374981; http://dx.doi.org/10. 1038/nature01075
    • (2002) Nature , vol.419 , pp. 624-629
    • Varambally, S.1    Dhanasekaran, S.M.2    Zhou, M.3    Barrette, T.R.4    Kumar-Sinha, C.5    Sanda, M.G.6
  • 40
    • 82755191151 scopus 로고    scopus 로고
    • Evi1 forms a bridge between the epigenetic machinery and signaling pathways
    • PMID:21795762
    • Yoshimi A, Kurokawa M. Evi1 forms a bridge between the epigenetic machinery and signaling pathways. Oncotarget 2011; 2:575-86; PMID:21795762
    • (2011) Oncotarget , vol.2 , pp. 575-586
    • Yoshimi, A.1    Kurokawa, M.2
  • 41
    • 79953683693 scopus 로고    scopus 로고
    • Evi1 represses pten expression and activates pi3kaktmtor via interactions with polycomb proteins
    • PMID:21289308
    • Yoshimi A, Goyama S, Watanabe-Okochi N, Yoshiki Y, Nannya Y, Nitta E, et al. Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. Blood 2011; 117:3617-28; PMID:21289308; http://dx.doi.org/10.1182/blood-2009-12-261602
    • (2011) Blood , vol.117 , pp. 3617-3628
    • Yoshimi, A.1    Goyama, S.2    Watanabe-Okochi, N.3    Yoshiki, Y.4    Nannya, Y.5    Nitta, E.6
  • 43
    • 84868622986 scopus 로고    scopus 로고
    • Genetic and epigenetic loss of microrna-31 leads to feed-forward expression of ezh2 in melanoma
    • PMID:22948084
    • Asangani IA, Harms PW, Dodson L, Pandhi M, Kunju LP, Maher CA, et al. Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. Oncotarget 2012; 3:1011-25; PMID:22948084
    • (2012) Oncotarget , vol.3 , pp. 1011-1025
    • Asangani, I.A.1    Harms, P.W.2    Dodson, L.3    Pandhi, M.4    Kunju, L.P.5    Maher, C.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.