Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR)

Drug Metabolism and Pharmacokinetics

Volumn 28, Issue 4, 2013, Pages 290-298

  Imai, Jun ^a   Yamazoe, Yasushi ^a   Yoshinari, Kouichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Agonistic ligand; CAR; Cell based reporter assay; Epitope tag; Species difference

Indexed keywords

2 ETHYLBUTYRIC ACID; 2 TERT BUTOXYETHANOL; 2 VINYLPYRIDINE; 3 AMINOPHENOL; 3 METHOXY 3 METHYL 1 BUTANOL; 3 METHYL 1,5 PENTANEDIOL; 4 AMINOPHENOL; 4 ETHYLMORPHOLINE; ACETOACETIC ACID; ACETOACETIC ACID METHYL ESTER; ACETONYLACETONE; ANDROSTANE DERIVATIVE; BENZONITRILE; BETA ALANINE; CARBOXY TERMINAL TELOPEPTIDE; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; EPITOPE; HYDRAZINE MONOHYDRATE; INDUSTRIAL CHEMICAL; META CRESOL; METHACRYLAMIDE; METHYLANILINE; METHYLCYCLOHEXANE; NEOPENTYL GLYCOL; NICOTINONITRILE; PHENOBARBITAL; PYRIDINE; THIOPHENE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL ASSAY; CELL BASED REPORTER ASSAY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANDROSTANOLS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL ASSAY; CLOTRIMAZOLE; EPITOPES; HEP G2 CELLS; HUMANS; LIGANDS; LIVER; MICE; PHENOBARBITAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SPECIES SPECIFICITY;

EID: 84883177598     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-12-RG-112     Document Type: Article

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