-
1
-
-
84874189388
-
Caspase-11 protects against bacteria that escape the vacuole
-
Aachoui, Y., Leaf, I.A., Hagar, J.A., Fontana, M.F., Campos, C.G., Zak, D.E., Tan, M.H., Cotter, P.A., Vance, R.E., Aderem, A., et al. Caspase-11 protects against bacteria that escape the vacuole. Science 339 (2013), 975–978.
-
(2013)
Science
, vol.339
, pp. 975-978
-
-
Aachoui, Y.1
Leaf, I.A.2
Hagar, J.A.3
Fontana, M.F.4
Campos, C.G.5
Zak, D.E.6
Tan, M.H.7
Cotter, P.A.8
Vance, R.E.9
Aderem, A.10
-
2
-
-
66349093381
-
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
-
Akhter, A., Gavrilin, M.A., Frantz, L., Washington, S., Ditty, C., Limoli, D., Day, C., Sarkar, A., Newland, C., Butchar, J., et al. Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog., 5, 2009, e1000361.
-
(2009)
PLoS Pathog.
, vol.5
, pp. e1000361
-
-
Akhter, A.1
Gavrilin, M.A.2
Frantz, L.3
Washington, S.4
Ditty, C.5
Limoli, D.6
Day, C.7
Sarkar, A.8
Newland, C.9
Butchar, J.10
-
3
-
-
58449083290
-
Pyroptosis: host cell death and inflammation
-
Bergsbaken, T., Fink, S.L., Cookson, B.T., Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7 (2009), 99–109.
-
(2009)
Nat. Rev. Microbiol.
, vol.7
, pp. 99-109
-
-
Bergsbaken, T.1
Fink, S.L.2
Cookson, B.T.3
-
4
-
-
31744441475
-
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
-
Boyden, E.D., Dietrich, W.F., Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat. Genet. 38 (2006), 240–244.
-
(2006)
Nat. Genet.
, vol.38
, pp. 240-244
-
-
Boyden, E.D.1
Dietrich, W.F.2
-
5
-
-
84945902536
-
Immunology: caspase target drives pyroptosis
-
Broz, P., Immunology: caspase target drives pyroptosis. Nature 526 (2015), 642–643.
-
(2015)
Nature
, vol.526
, pp. 642-643
-
-
Broz, P.1
-
6
-
-
84976516826
-
Inflammasomes: mechanism of assembly, regulation and signalling
-
Broz, P., Dixit, V.M., Inflammasomes: mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 16 (2016), 407–420.
-
(2016)
Nat. Rev. Immunol.
, vol.16
, pp. 407-420
-
-
Broz, P.1
Dixit, V.M.2
-
7
-
-
78650210802
-
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
-
Broz, P., von Moltke, J., Jones, J.W., Vance, R.E., Monack, D.M., Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 8 (2010), 471–483.
-
(2010)
Cell Host Microbe
, vol.8
, pp. 471-483
-
-
Broz, P.1
von Moltke, J.2
Jones, J.W.3
Vance, R.E.4
Monack, D.M.5
-
8
-
-
0029946714
-
Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides
-
Coutts, S.J., Kelly, T.A., Snow, R.J., Kennedy, C.A., Barton, R.W., Adams, J., Krolikowski, D.A., Freeman, D.M., Campbell, S.J., Ksiazek, J.F., et al. Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. J. Med. Chem. 39 (1996), 2087–2094.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2087-2094
-
-
Coutts, S.J.1
Kelly, T.A.2
Snow, R.J.3
Kennedy, C.A.4
Barton, R.W.5
Adams, J.6
Krolikowski, D.A.7
Freeman, D.M.8
Campbell, S.J.9
Ksiazek, J.F.10
-
9
-
-
84978419608
-
Pore-forming activity and structural autoinhibition of the gasdermin family
-
Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.C., Shao, F., Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535 (2016), 111–116.
-
(2016)
Nature
, vol.535
, pp. 111-116
-
-
Ding, J.1
Wang, K.2
Liu, W.3
She, Y.4
Sun, Q.5
Shi, J.6
Sun, H.7
Wang, D.C.8
Shao, F.9
-
10
-
-
84957605863
-
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
-
Doench, J.G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E.W., Donovan, K.F., Smith, I., Tothova, Z., Wilen, C., Orchard, R., et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nat. Biotechnol. 34 (2016), 184–191.
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 184-191
-
-
Doench, J.G.1
Fusi, N.2
Sullender, M.3
Hegde, M.4
Vaimberg, E.W.5
Donovan, K.F.6
Smith, I.7
Tothova, Z.8
Wilen, C.9
Orchard, R.10
-
11
-
-
84914132432
-
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
-
Guey, B., Bodnar, M., Manie, S.N., Tardivel, A., Petrilli, V., Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function. Proc. Natl. Acad. Sci. USA 111 (2014), 17254–17259.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 17254-17259
-
-
Guey, B.1
Bodnar, M.2
Manie, S.N.3
Tardivel, A.4
Petrilli, V.5
-
12
-
-
84936891896
-
Inflammasomes: mechanism of action, role in disease, and therapeutics
-
Guo, H., Callaway, J.B., Ting, J.P., Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21 (2015), 677–687.
-
(2015)
Nat. Med.
, vol.21
, pp. 677-687
-
-
Guo, H.1
Callaway, J.B.2
Ting, J.P.3
-
13
-
-
84883790050
-
Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock
-
Hagar, J.A., Powell, D.A., Aachoui, Y., Ernst, R.K., Miao, E.A., Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 341 (2013), 1250–1253.
-
(2013)
Science
, vol.341
, pp. 1250-1253
-
-
Hagar, J.A.1
Powell, D.A.2
Aachoui, Y.3
Ernst, R.K.4
Miao, E.A.5
-
14
-
-
84949091051
-
Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion
-
He, W.T., Wan, H., Hu, L., Chen, P., Wang, X., Huang, Z., Yang, Z.H., Zhong, C.Q., Han, J., Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res. 25 (2015), 1285–1298.
-
(2015)
Cell Res.
, vol.25
, pp. 1285-1298
-
-
He, W.T.1
Wan, H.2
Hu, L.3
Chen, P.4
Wang, X.5
Huang, Z.6
Yang, Z.H.7
Zhong, C.Q.8
Han, J.9
-
15
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D.R., Latz, E., Fitzgerald, K.A., AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458 (2009), 514–518.
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
Horvath, G.5
Caffrey, D.R.6
Latz, E.7
Fitzgerald, K.A.8
-
16
-
-
84995483254
-
IL-1beta, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis
-
Jorgensen, I., Lopez, J.P., Laufer, S.A., Miao, E.A., IL-1beta, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis. Eur. J. Immunol. 46 (2016), 2761–2766.
-
(2016)
Eur. J. Immunol.
, vol.46
, pp. 2761-2766
-
-
Jorgensen, I.1
Lopez, J.P.2
Laufer, S.A.3
Miao, E.A.4
-
17
-
-
80455176839
-
Non-canonical inflammasome activation targets caspase-11
-
Kayagaki, N., Warming, S., Lamkanfi, M., Vande Walle, L., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. Non-canonical inflammasome activation targets caspase-11. Nature 479 (2011), 117–121.
-
(2011)
Nature
, vol.479
, pp. 117-121
-
-
Kayagaki, N.1
Warming, S.2
Lamkanfi, M.3
Vande Walle, L.4
Louie, S.5
Dong, J.6
Newton, K.7
Qu, Y.8
Liu, J.9
Heldens, S.10
-
18
-
-
84883775365
-
Noncanonical inflammasome activation by intracellular LPS independent of TLR4
-
Kayagaki, N., Wong, M.T., Stowe, I.B., Ramani, S.R., Gonzalez, L.C., Akashi-Takamura, S., Miyake, K., Zhang, J., Lee, W.P., Muszynski, A., et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341 (2013), 1246–1249.
-
(2013)
Science
, vol.341
, pp. 1246-1249
-
-
Kayagaki, N.1
Wong, M.T.2
Stowe, I.B.3
Ramani, S.R.4
Gonzalez, L.C.5
Akashi-Takamura, S.6
Miyake, K.7
Zhang, J.8
Lee, W.P.9
Muszynski, A.10
-
19
-
-
84942856523
-
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
-
Kayagaki, N., Stowe, I.B., Lee, B.L., O'Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q.T., et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526 (2015), 666–671.
-
(2015)
Nature
, vol.526
, pp. 666-671
-
-
Kayagaki, N.1
Stowe, I.B.2
Lee, B.L.3
O'Rourke, K.4
Anderson, K.5
Warming, S.6
Cuellar, T.7
Haley, B.8
Roose-Girma, M.9
Phung, Q.T.10
-
20
-
-
84901310586
-
Mechanisms and functions of inflammasomes
-
Lamkanfi, M., Dixit, V.M., Mechanisms and functions of inflammasomes. Cell 157 (2014), 1013–1022.
-
(2014)
Cell
, vol.157
, pp. 1013-1022
-
-
Lamkanfi, M.1
Dixit, V.M.2
-
21
-
-
58149287750
-
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
-
Lamkanfi, M., Kanneganti, T.D., Van Damme, P., Vanden Berghe, T., Vanoverberghe, I., Vandekerckhove, J., Vandenabeele, P., Gevaert, K., Nunez, G., Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol. Cell. Proteomics 7 (2008), 2350–2363.
-
(2008)
Mol. Cell. Proteomics
, vol.7
, pp. 2350-2363
-
-
Lamkanfi, M.1
Kanneganti, T.D.2
Van Damme, P.3
Vanden Berghe, T.4
Vanoverberghe, I.5
Vandekerckhove, J.6
Vandenabeele, P.7
Gevaert, K.8
Nunez, G.9
-
22
-
-
84978374487
-
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
-
Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V.G., Wu, H., Lieberman, J., Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535 (2016), 153–158.
-
(2016)
Nature
, vol.535
, pp. 153-158
-
-
Liu, X.1
Zhang, Z.2
Ruan, J.3
Pan, Y.4
Magupalli, V.G.5
Wu, H.6
Lieberman, J.7
-
23
-
-
78449269290
-
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
-
Miao, E.A., Leaf, I.A., Treuting, P.M., Mao, D.P., Dors, M., Sarkar, A., Warren, S.E., Wewers, M.D., Aderem, A., Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11 (2010), 1136–1142.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 1136-1142
-
-
Miao, E.A.1
Leaf, I.A.2
Treuting, P.M.3
Mao, D.P.4
Dors, M.5
Sarkar, A.6
Warren, S.E.7
Wewers, M.D.8
Aderem, A.9
-
24
-
-
84994558912
-
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis
-
Okondo, M.C., Johnson, D.C., Sridharan, R., Go, E.B., Chui, A.J., Wang, M.S., Poplawski, S.E., Wu, W., Liu, Y., Lai, J.H., et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat. Chem. Biol. 13 (2017), 46–53.
-
(2017)
Nat. Chem. Biol.
, vol.13
, pp. 46-53
-
-
Okondo, M.C.1
Johnson, D.C.2
Sridharan, R.3
Go, E.B.4
Chui, A.J.5
Wang, M.S.6
Poplawski, S.E.7
Wu, W.8
Liu, Y.9
Lai, J.H.10
-
25
-
-
84905262730
-
Improved vectors and genome-wide libraries for CRISPR screening
-
Sanjana, N.E., Shalem, O., Zhang, F., Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11 (2014), 783–784.
-
(2014)
Nat. Methods
, vol.11
, pp. 783-784
-
-
Sanjana, N.E.1
Shalem, O.2
Zhang, F.3
-
26
-
-
84982102736
-
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
-
Sborgi, L., Ruhl, S., Mulvihill, E., Pipercevic, J., Heilig, R., Stahlberg, H., Farady, C.J., Muller, D.J., Broz, P., Hiller, S., GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J. 35 (2016), 1766–1778.
-
(2016)
EMBO J.
, vol.35
, pp. 1766-1778
-
-
Sborgi, L.1
Ruhl, S.2
Mulvihill, E.3
Pipercevic, J.4
Heilig, R.5
Stahlberg, H.6
Farady, C.J.7
Muller, D.J.8
Broz, P.9
Hiller, S.10
-
27
-
-
84906571225
-
Inflammatory caspases are innate immune receptors for intracellular LPS
-
Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., Shao, F., Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514 (2014), 187–192.
-
(2014)
Nature
, vol.514
, pp. 187-192
-
-
Shi, J.1
Zhao, Y.2
Wang, Y.3
Gao, W.4
Ding, J.5
Li, P.6
Hu, L.7
Shao, F.8
-
28
-
-
84942892037
-
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
-
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., Shao, F., Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526 (2015), 660–665.
-
(2015)
Nature
, vol.526
, pp. 660-665
-
-
Shi, J.1
Zhao, Y.2
Wang, K.3
Shi, X.4
Wang, Y.5
Huang, H.6
Zhuang, Y.7
Cai, T.8
Wang, F.9
Shao, F.10
-
29
-
-
78249253033
-
Secondary necrosis: the natural outcome of the complete apoptotic program
-
Silva, M.T., Secondary necrosis: the natural outcome of the complete apoptotic program. FEBS Lett. 584 (2010), 4491–4499.
-
(2010)
FEBS Lett.
, vol.584
, pp. 4491-4499
-
-
Silva, M.T.1
-
30
-
-
0026507126
-
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
-
Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J., et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356 (1992), 768–774.
-
(1992)
Nature
, vol.356
, pp. 768-774
-
-
Thornberry, N.A.1
Bull, H.G.2
Calaycay, J.R.3
Chapman, K.T.4
Howard, A.D.5
Kostura, M.J.6
Miller, D.K.7
Molineaux, S.M.8
Weidner, J.R.9
Aunins, J.10
-
31
-
-
0032785022
-
The proteolytic procaspase activation network: an in vitro analysis
-
Van de Craen, M., Declercq, W., Van den brande, I., Fiers, W., Vandenabeele, P., The proteolytic procaspase activation network: an in vitro analysis. Cell Death Differ. 6 (1999), 1117–1124.
-
(1999)
Cell Death Differ.
, vol.6
, pp. 1117-1124
-
-
Van de Craen, M.1
Declercq, W.2
Van den brande, I.3
Fiers, W.4
Vandenabeele, P.5
-
32
-
-
84893835896
-
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
-
Van Opdenbosch, N., Gurung, P., Vande Walle, L., Fossoul, A., Kanneganti, T.D., Lamkanfi, M., Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat. Commun., 5, 2014, 3209.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3209
-
-
Van Opdenbosch, N.1
Gurung, P.2
Vande Walle, L.3
Fossoul, A.4
Kanneganti, T.D.5
Lamkanfi, M.6
-
33
-
-
84907270863
-
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
-
Xu, H., Yang, J., Gao, W., Li, L., Li, P., Zhang, L., Gong, Y.N., Peng, X., Xi, J.J., Chen, S., et al. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature 513 (2014), 237–241.
-
(2014)
Nature
, vol.513
, pp. 237-241
-
-
Xu, H.1
Yang, J.2
Gao, W.3
Li, L.4
Li, P.5
Zhang, L.6
Gong, Y.N.7
Peng, X.8
Xi, J.J.9
Chen, S.10
-
34
-
-
79960987021
-
A public genome-scale lentiviral expression library of human ORFs
-
Yang, X., Boehm, J.S., Yang, X., Salehi-Ashtiani, K., Hao, T., Shen, Y., Lubonja, R., Thomas, S.R., Alkan, O., Bhimdi, T., et al. A public genome-scale lentiviral expression library of human ORFs. Nat. Methods 8 (2011), 659–661.
-
(2011)
Nat. Methods
, vol.8
, pp. 659-661
-
-
Yang, X.1
Boehm, J.S.2
Yang, X.3
Salehi-Ashtiani, K.4
Hao, T.5
Shen, Y.6
Lubonja, R.7
Thomas, S.R.8
Alkan, O.9
Bhimdi, T.10
-
35
-
-
80053349020
-
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
-
Zhao, Y., Yang, J., Shi, J., Gong, Y.N., Lu, Q., Xu, H., Liu, L., Shao, F., The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477 (2011), 596–600.
-
(2011)
Nature
, vol.477
, pp. 596-600
-
-
Zhao, Y.1
Yang, J.2
Shi, J.3
Gong, Y.N.4
Lu, Q.5
Xu, H.6
Liu, L.7
Shao, F.8
|