Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides

Journal of Medicinal Chemistry

Volumn 39, Issue 10, 1996, Pages 2087-2094

  Coutts, Simon J ^a   Kelly, Terence A ^a   Snow, Roger J ^a   Kennedy, Charles A ^a   Barton, Randall W ^a   Adams, Julian ^a,c   Krolikowski, Dale A ^a   Freeman, Dorothy M ^a   Campbell, Scot J ^a   Ksiazek, John F ^a   Bachovchin, William W ^b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MyoGenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORONIC ACID DERIVATIVE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; IMMUNOSUPPRESSIVE AGENT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MIXED LYMPHOCYTE REACTION; NORMAL HUMAN; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

BORONIC ACIDS; DIPEPTIDYL PEPTIDASES; ENZYME INHIBITORS; HUMANS; LYMPHOCYTE CULTURE TEST, MIXED; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029946714     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950732f     Document Type: Article

References (40)

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39. For general experimental including details on the enzymatic assay, see ref 15.
40. Abbreviations: Aibu, α-aminoisobutyric acid; Abu, 2-aminobutyric acid; Phg, phenylglycine; tLeu, tert-leucine; Azet, azetidine-2-carboxylic acid.