Study of TiO2 P25nanoparticles genotoxicity on lung, blood, and liver cells in lung overload andnon-overload conditionsafter repeated respiratory exposure in rats

Toxicological Sciences

Volumn 156, Issue 2, 2017, Pages 527-537

  Relier, Charlène ^a   Dubreuil, Marielle ^a,b   Garcìa, Omar Lozano ^c,d   Cordelli, Eugenia ^e   Mejia, Jorge ^c   Eleuteri, Patrizia ^e   Robidel, Franck ^a   Loret, Thomas ^a   Pacchierotti, Francesca ^e   Lucas, S ^c   Lacroix, Ghislaine ^a   Trouiller, Bénédicte ^a  

^a INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

^b PESSAC   (France)

^c University of Namur   (Belgium)

^d SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

^e ENEA C R CASACCIA   (Italy)

Author keywords

DNA damage; Glutathione; Inflammation; Nanomaterials; Rodents; Titanium dioxide

Indexed keywords

DNA; GLUTATHIONE; HISTONE H2AX; TITANIUM DIOXIDE NANOPARTICLE; MUTAGENIC AGENT; NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; CHROMOSOME DAMAGE; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ERYTHROCYTE; GENE MUTATION; GENOTOXICITY; GENOTOXICITY ASSAY; INFLAMMATION; LIVER CELL; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; LUNG BURDEN; LUNG CLEARANCE; LYMPHOCYTE; MACROPHAGE; MALE; MICRONUCLEUS TEST; MUTATIONAL ANALYSIS; NANOTOXICOLOGY; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; RAT; SURFACE AREA; ANIMAL; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; LIVER; LUNG; PATHOLOGY; SPRAGUE DAWLEY RAT; SURFACE PROPERTY; TISSUE DISTRIBUTION;

ANIMALS; CELL SURVIVAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; INHALATION EXPOSURE; LIVER; LUNG; MALE; MUTAGENS; NANOPARTICLES; OXIDATIVE STRESS; PARTICLE SIZE; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; TISSUE DISTRIBUTION; TITANIUM;

EID: 85017096305     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfx006     Document Type: Article

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