Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance

Inhalation Toxicology

Volumn 12, Issue 12, 2000, Pages 1113-1126

  Tran, C L ^a   Buchanan, D ^a   Cullen, R T ^a   Searl, A ^a   Jones, A D ^a   Donaldson, K ^a  

^a INSTITUTE OF OCCUPATIONAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0033646585     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370050166796     Document Type: Article

References (27)

1. Irreversible changes induced in rat lung by dust overload
2. An overload hypothesis for pulmonary clearance of UICC amosite fibres inhaled by rats
3. Lung Macrophages: How many kinds are there? What do they do?
4. Kinetics of the bronchoalveolar leukocyte response in rats during exposure to equal airborne mass concentration of quartz, chrysotile asbestos or titanium dioxide
5. Role of inflammation in the development of rat lung tumors in response to chronic particle exposure
6. Pulmonary inflammatory chemokine and mutagenic responses in rats after subchronic inhalation of carbon black
7. Cytokines and particle-induced inflammatory cell recruitment
8. Alveolar macrophage mediated pulmonary clearance suppressed by drug-induced phospholipidosis
9. Translocation of particles from pulmonary alveoli into the interstitium
10. Surface reactivity in the pathogenic response to particulates
11. Defence mechanisms against inhaled particles and associated particle-cell interactions
12. Influence of particle surface area on the toxicity of insoluble manganese dioxide dusts
13. Possible mechanisms to explain dust overloading of the lungs
14. Overloading of lung clearance during chronic exposure of experimental animals to particles
15. Volumetric loading of alveolar macrophages (AM): A possible basis for diminished AM-mediated particle clearance
16. Correlation between particle size, in vivo particle persistence, and lung injury
17. Increased pulmonary toxicity of inhaled ultrafine particles: Due to lung overload alone?
18. Compartmental modeling of the long-term retention of insoluble particles deposited in the alveolar region of the lung
19. Overloading of particles and fibres
20. A dosimetric approach for relating the biological response of the lung to the accumulation of inhaled mineral dust
21. Pulmonary macrophages attracted to inhaled particles through complement activation
22. Inhalation of concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation