Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: How can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Pauluhn, Jürgen ^a,b  

^a BAYER PHARMA AG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Disposition; Dissolution; Micronsized particles; Nano size particles; Repeated inhalation exposure; Volume displacement lung overload

Indexed keywords

BARIUM SULFATE; ENVIRONMENTAL, INDUSTRIAL AND DOMESTIC CHEMICALS; POORLY SOLUBLE LOW TOXICITY GRANULAR PARTICLE; UNCLASSIFIED DRUG; ZINC; ZINC OXIDE; AIR POLLUTANT; PARTICULATE MATTER;

ANALYTICAL PARAMETERS; BIOAVAILABILITY; CONCENTRATION RESPONSE; DEPOSITION RELATED METRIC; DISSOLUTION; HEALTH HAZARD; HOMEOSTATIC THRESHOLD; HUMAN; MATHEMATICAL ANALYSIS; NONHUMAN; OCCUPATIONAL EXPOSURE LEVEL; PARTICLE SIZE; PREDICTION; PRIORITY JOURNAL; RETENTION RELATED METRIC; REVIEW; RISK ASSESSMENT; STUDY DESIGN; SURFACE PROPERTY; TOXIC INHALATION; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; AIR POLLUTANT; ANALYSIS; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; EXPOSURE; LUNG; MAXIMUM ALLOWABLE CONCENTRATION; METABOLISM; METHODOLOGY; OCCUPATIONAL MEDICINE; PARTICULATE MATTER; PRACTICE GUIDELINE; PROCEDURES; RESPIRATORY TRACT MUCOSA; STANDARDS; TOXICITY; TOXICOKINETICS; TOXICOLOGY;

AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; GUIDELINES AS TOPIC; HUMANS; INHALATION EXPOSURE; LUNG; MODELS, BIOLOGICAL; OCCUPATIONAL MEDICINE; PARTICULATE MATTER; RESEARCH DESIGN; RESPIRATORY MUCOSA; THRESHOLD LIMIT VALUES; TOXICOKINETICS; TOXICOLOGY;

EID: 84924269982     PISSN: 17438977     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0072-2     Document Type: Review

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