Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes

Cell Metabolism

Volumn 25, Issue 4, 2017, Pages 883-897.e8

  Morita, Shuhei ^a,b,c   Villalta, S Armando ^b,f   Feldman, Hannah C ^d   Register, Ames C ^d   Rosenthal, Wendy ^b   Hoffmann Petersen, Ingeborg T ^a,b,c   Mehdizadeh, Morvarid ^b   Ghosh, Rajarshi ^a,b,c   Wang, Likun ^a,b,c   Colon Negron, Kevin ^a,b,c   Meza Acevedo, Rosa ^a,b,c   Backes, Bradley J ^a,b   Maly, Dustin J ^d,e   Bluestone, Jeffrey A ^a,b   Papa, Feroz R ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

apoptosis; c Abl; ER stress; imatinib; inflammation; insulitis; IRE1; NOD; type 1 diabetes; unfolded protein response; cell dysfunction

Indexed keywords

ABELSON KINASE; IMATINIB; ERN1 PROTEIN, HUMAN; ERN1 PROTEIN, MOUSE; GNF-2 COMPOUND; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; PYRIMIDINE DERIVATIVE; RIBONUCLEASE;

AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM MEMBRANE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IMMUNOBLOTTING; INSULIN DEPENDENT DIABETES MELLITUS; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; HUMAN; MALE; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; RAT; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; FEMALE; HUMANS; IMATINIB MESYLATE; INSULIN-SECRETING CELLS; MALE; MICE, INBRED NOD; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; RATS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 85017000536     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.03.018     Document Type: Article

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