N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor

Journal of Biological Chemistry

Volumn 284, Issue 42, 2009, Pages 29005-29014

  Choi, Yongmun ^a,b   Seeliger, Markus A ^c   Panjarian, Shoghag B ^d   Kim, Hakjoong ^a   Deng, Xianming ^a,b   Sim, Taebo ^a   Couch, Brian ^e   Koleske, Anthony J ^e   Smithgall, Thomas E ^d   Gray, Nathanael S ^a,b,f  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e YALE UNIVERSITY   (United States)

^f NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITOR; BINDING POCKETS; CELLULAR KINASE; CHEMICAL TOOLS; ENDOPLASMIC RETICULUM; INDIRECT IMMUNOFLUORESCENCE; INTRAMOLECULAR BINDING; ISOFORMS; KINASE ACTIVITY; KINASE DOMAINS; KINASE INHIBITORS; MYRISTOYLATION; TYROSINE KINASE; UNIQUE FEATURES;

AMINO ACIDS;

ABELSON KINASE; ARGININE KINASE; GNF 2; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME BINDING; ENZYME INHIBITION; ENZYME LOCALIZATION; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

3T3 CELLS; ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM; HUMANS; LIPIDS; MICE; MOLECULAR CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-ABL;

EID: 70350365399     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.026633     Document Type: Article

References (31)

1. Goodey, N. M., and Benkovic, S. J. (2008) Nat. Chem. Biol. 4, 474-482
2. Pendergast, A. M. (2002) Adv. Cancer Res. 85, 51-100
3. Kruh, G. D., Perego, R., Miki, T., and Aaronson, S. A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 5802-5806
4. Wen, S. T., and Van Etten, R. A. (1997) Genes Dev. 11, 2456-2467
5. Hantschel, O., and Superti-Furga, G. (2004) Nat. Rev. Mol. Cell Biol. 5, 33-44
6. Woodring, P. J., Hunter, T., and Wang, J. Y. (2003) J. Cell Sci. 116, 2613-2626
7. Nagar, B., Hantschel, O., Young, M. A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., and Kuriyan, J. (2003) Cell 112, 859-871
8. Hantschel, O., Nagar, B., Guettler, S., Kretzschmar, J., Dorey, K., Kuriyan, J., and Superti-Furga, G. (2003) Cell 112, 845-857
9. Wang, J. Y. (2004) Nat. Cell Biol. 6, 3-7
10. Weisberg, E., Manley, P. W., Cowan-Jacob, S. W., Hochhaus, A., and Griffin, J. D. (2007) Nat. Rev. Cancer 7, 345-356
11. Wong, S., McLaughlin, J., Cheng, D., Zhang, C., Shokat, K. M., and Witte, O. N. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 17456-17461
12. Karaman, M. W., Herrgard, S., Treiber, D. K., Gallant, P., Atteridge, C. E., Campbell, B. T., Chan, K. W., Ciceri, P., Davis, M. I., Edeen, P. T., Faraoni, R., Floyd, M., Hunt, J. P., Lockhart, D. J., Milanov, Z. V., Morrison, M. J., Pallares, G., Patel, H. K., Pritchard, S., Wodicka, L. M., and Zarrinkar, P. P. (2008) Nat. Biotechnol. 26, 127-132
13. Adrián, F. J., Ding, Q., Sim, T., Velentza, A., Sloan, C., Liu, Y., Zhang, G., Hur, W., Ding, S., Manley, P., Mestan, J., Fabbro, D., and Gray, N. S. (2006) Nat. Chem. Biol. 2, 95-102
14. Songyang, Z., Carraway, K. L., 3rd, Eck, M. J., Harrison, S. C., Feldman, R. A., Mohammadi, M., Schlessinger, J., Hubbard, S. R., Smith, D. P., and Eng, C. (1995) Nature 373, 536-539
15. Barker, S. C., Kassel, D. B., Weigl, D., Huang, X., Luther, M. A., and Knight, W. B. (1995) Biochemistry 34, 14943-14851
16. Seeliger, M. A., Young, M., Henderson, M. N., Pellicena, P., King, D. S., Falick, A. M., and Kuriyan, J. (2005) Protein Sci. 14, 3135-3139
17. Foulkes, J. G., Chow, M., Gorka, C., Frackelton, A. R., Jr., and Baltimore, D. (1985) J. Biol. Chem. 260, 8070-8077
18. Koleske, A. J., Gifford, A. M., Scott, M. L., Nee, M., Bronson, R. T., Miczek, K. A., and Baltimore, D. (1998) Neuron 21, 1259-1272
19. Kalies, K. U., Rapoport, T. A., and Hartmann, E. (1998) J. Cell Biol. 141, 887-894
20. Görlich, D., and Rapoport, T. A. (1993) Cell 75, 615-630
21. Miller, A. L., Wanp, Y., Mooseker, M. S., and Koleske, A. J. (2004) J. Cell Biol. 165, 407-419
22. Cowan-Jacob, S. W., Fendrich, G., Manley, P. W., Jahnke, W., Fabbro, D., Liebetanz, J., and Meyer, T. (2005) Structure 13, 861-871
23. Diskin, R., Engelberg, D., and Livnah, O. (2008) J. Mol. Biol. 375, 70-79
24. Nagar, B., Hantschel, O., Seeliger, M., Davies, J. M., Weis, W. L, Superti-Furga, G., and Kuriyan, J. (2006) Mol. Cell 21, 787-798
25. Zhou, V., Gao, X., Han, S., Brinker, A., Caldwell, J. S., and Gu, X. J. (2008) Anal. Biochem. 385, 300-308
26. Ito, Y., Pandey, P., Mishra, N., Kumar, S., Narula, N., Kharbanda, S., Saxena, S., and Kufe, D. (2001) Mol. Cell Biol. 21, 6233-6242
27. Lin, J., and Arlinghaus, R. (2008) Oncogene 27, 4385-4391
28. Srinivasan, D., Sims, J. T., and Plattner, R. (2008) Oncogene 27, 1095-1105
29. Sirvent, A., Boureux, A., Simon, V., Leroy, C., and Roche, S. (2007) Oncogene 26, 7313-7323
30. Lin, J., Sun, T., Ji, L., Deng, W., Roth, J., Minna, J., and Arlinghaus, R. (2007) Oncogene 26, 6989-6996
31. Woodring, P. J., Hunter, T., and Wang, J. Y. (2001) J. Biol. Chem. 276, 27104-27110